Ortofen, 20 pcs., 25 mg, enteric-coated tablets

Pharmacodynamics and pharmacokinetics

The active substance is diclofenac . The drug has antipyretic, analgesic and anti-inflammatory effects. The main component of the drug is a derivative of phenylacetic acid. The main mechanism of action is aimed at non-selective inhibition of cyclooxygenases-1,2, a decrease in the concentration of prostaglandins in the inflammatory focus, and disruption of the metabolic process of arachidonic acid . The drug has additional antiplatelet activity.

Mechanism of action of Ortofen

The drug Ortofen is a derivative of phenylacetic acid. Belongs to the group of drugs non-steroidal anti-inflammatory drugs. It has the following beneficial effects on the body:

• lowers the temperature and quickly eliminates heat at the site of inflammation;
• relieves the inflammatory process;
• reduces swelling of soft tissues;
• desensitizing (anti-allergic) effect;
• inhibits the production of proteoglycan in cartilage;
• eliminates painful sensations.

This is achieved by suppressing the activity of the synthesis of prostaglandins - enzyme substances that are directly involved in the formation and growth of the inflammatory process caused by infectious or microbial microflora. The ability to quickly eliminate pain at the site of inflammation occurs as a result of bilateral suppression of prostaglandin synthesis:

• in the periphery;
• in the central nervous system, by inhibiting the partial synthesis of arachidonic acid.

The simultaneous intake of food and tablets significantly slows down the rate of absorption, but this does not affect absorption in the gastrointestinal tract. The active components are almost completely bound to blood proteins, mostly albumin. The maximum concentration in blood plasma directly depends on the route of administration.

Indications for use of Ortofen

What do tablets and ointment help with? Let's consider the indications for the use of this medication.

The drug is prescribed for the treatment of diseases of the musculoskeletal system of degenerative and inflammatory origin: Personage-Turner disease amyotrophy ), ankylosing spondylitis (ankylosing spondylitis), chronic juvenile arthritis, rheumatism, arthritis in Reiter's disease , psoriatic arthritis, rheumatoid arthritis, osteoarthritis.

The drug is effective for relieving pain after surgery, trauma, cancer, neuralgia, sciatica , bursitis, myalgia, radiculitis, arthralgia, toothache, migraine, headache, tendinitis , ossalgia, lumbago.

The medication is used for adnexitis, inflammatory diseases of the pelvic organs, algodismenorrhea , otitis, pharyngitis, tonsillitis and other diseases of the ENT organs.

The drug is prescribed for the relief of febrile syndrome, which accompanies the course of many infectious and “cold” diseases.

What is Ortofen intended for?

Before starting treatment, consult your doctor! When using the drug, you must adhere to the doses recommended by your doctor. According to generally accepted approaches to the treatment of infectious and inflammatory diseases, it is also necessary to use etiotropic drugs. An isolated increase in body temperature is not an indication for the use of the drug. Short-term treatment (maximum 2 weeks) of the following acute conditions:

• post-traumatic pain, inflammation and swelling, for example due to sprains;
• post-operative pain, inflammation and swelling, for example after dental or orthopedic surgery;
• pain and/or inflammation that accompany inflammatory gynecological diseases, for example, primary dysmenorrhea or adnexitis;
• pain syndromes from the spine;
• rheumatic diseases of extra-articular tissues;

• as an adjuvant for infections of JlOP organs, for example, pharyngotonsillitis, otitis media, which are accompanied by severe pain and inflammation.
• migraine attacks with or without warning signs

Contraindications

Ortofen is not used for “aspirin” asthma , with intolerance to diclofenac, with various disorders of the blood coagulation system, with hematopoiesis disorders, with the “aspirin” triad (recurrent polyposis of the nose, paranasal sinuses combined with bronchial asthma and intolerance to acetylsalicylic acid , pyrazolone-type medications), during pregnancy, erosive and ulcerative lesions in the digestive tract, hemophilia , breastfeeding, anemia, leukopenia, tendency to bleeding, prolongation of the bleeding period, children under 6 years of age.

For swelling, alcoholism, renal and liver failure, arterial hypertension, erosive and ulcerative lesions of the digestive system, for decompensated forms of chronic heart failure, for anemia, bronchial asthma, diabetes mellitus , in the postoperative period, for acute inducible hepatic porphyrias and elderly patients Ortofen prescribed with caution.

Ortofen ampoules

Pharmachologic effect:

NSAID, phenylacetic acid derivative; has anti-inflammatory, analgesic and antipyretic effects. By indiscriminately inhibiting COX1 and COX2, it disrupts the metabolism of arachidonic acid and reduces the amount of Pg at the site of inflammation. Most effective for inflammatory pain. Like all NSAIDs, the drug has antiplatelet activity.

Indications:

Inflammatory and degenerative diseases of the musculoskeletal system: rheumatoid, psoriatic, juvenile chronic arthritis, ankylosing spondylitis (ankylosing spondylitis), neuralgic amyotrophy (Personage-Turner disease), osteoarthritis, rheumatism, gouty arthritis (in case of an acute attack of gout, fast-acting dosage forms are preferred), arthritis due to Reiter's disease. Pain syndrome: headache (including migraine) and toothache, bursitis, tendinitis, lumbago, sciatica, ossalgia, neuralgia, myalgia, arthralgia, radiculitis, in cancer, post-traumatic and postoperative pain syndrome accompanied by inflammation. Algodismenorrhea; inflammatory processes in the pelvis, incl. adnexitis; childbirth (as an analgesic and tocolytic agent). Infectious and inflammatory diseases of the ENT organs with severe pain syndrome (as part of complex therapy): pharyngitis, tonsillitis, otitis media. Feverish syndrome with “colds” and infectious diseases.

Contraindications:

Hypersensitivity (including to other NSAIDs), “aspirin” triad (a combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to ASA and pyrazolone-type drugs), hematopoietic disorders (leukopenia and anemia), various blood clotting disorders (including hemophilia, prolongation of bleeding time, tendency to bleed), erosive and ulcerative lesions of the gastrointestinal tract in the acute phase, bleeding from the gastrointestinal tract, pregnancy, lactation, young children (up to 6 years). For rectal use: rectal bleeding, hemorrhoids, injury or inflammation of the rectum (including the anus). Caution. Anemia, bronchial asthma, decompensated CHF, arterial hypertension, edema syndrome, liver and/or renal failure, alcoholism, diverticulitis, erosive and ulcerative diseases of the gastrointestinal tract without exacerbation, diabetes mellitus, old age, postoperative period, inducible acute hepatic porphyria.

Side effects:

From the digestive organs. More often than 1% - abdominal pain or spasm, bloating, diarrhea, dyspepsia, nausea, constipation, flatulence, increased activity of liver transaminases, peptic ulcer, incl. with complications (perforation, bleeding), gastrointestinal bleeding without ulcer. Less often than 1% - vomiting, jaundice, melena, blood in the stool, damage to the esophagus, aphthous stomatitis, dry mucous membranes (including the oral cavity), hepatitis, hepatonecrosis, cirrhosis, hepatorenal syndrome, changes in appetite, pancreatitis (including .ch. with concomitant hepatitis), colitis. From the nervous system. More often than 1% - headache, dizziness. Less often than 1% - sleep disturbance, drowsiness, depression, diplopia, anxiety, irritability, aseptic meningitis, convulsions, weakness. From the senses. More often than 1% - tinnitus. Less often than 1% - blurred visual perception, taste disturbance, hearing loss (including irreversible), scotoma. From the side of the skin. More often than 1% - skin rash, itchy skin. Less commonly 1% - alopecia, urticaria, eczema, toxic dermatitis, exudative erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), photosensitivity. From the genitourinary system. More often than 1% is fluid retention. Less often than 1% - nephrotic syndrome, proteinuria, oliguria, interstitial nephritis, papillary necrosis, acute renal failure, azotemia. From the hematopoietic organs. Less often than 1% - anemia (including hemolytic and aplastic), leukopenia, thrombocytopenia, eosinophilia, agranulocytosis, thrombocytopenic purpura. From the respiratory system. Less often than 1% - cough, bronchospasm, laryngeal edema. From the SSS side. Less often than 1% - increased blood pressure, congestive heart failure. Allergic reactions. Less often than 1% - swelling of the lips and tongue, anaphylactoid reactions, anaphylactic shock (usually develops rapidly). Overdose. Symptoms: dizziness, headache, hyperventilation, clouding of consciousness, in children - myoclonic convulsions, nausea, vomiting, abdominal pain, bleeding, impaired liver and kidney function. Treatment: gastric lavage, activated charcoal, symptomatic therapy aimed at eliminating increased blood pressure, renal dysfunction, convulsions, gastrointestinal irritation, respiratory depression. Forced diuresis and hemodialysis are ineffective.

Directions for use and dosage:

Orally, without chewing, during or after meals, adults - 25-50 mg 2-3 times a day. When the optimal therapeutic effect is achieved, the dose is gradually reduced and switched to maintenance treatment at a dose of 50 mg/day. The maximum daily dose is 150 mg. For children over 6 years of age and adolescents, only tablets with a regular duration of action of 25 mg are used; daily dose - 2 mg/kg child. For juvenile rheumatoid arthritis, the daily dose can be increased to 3 mg/kg. The tablets should be taken whole, without chewing, on an empty stomach, with a small amount of liquid. Long-acting diclofenac is prescribed 100 mg once a day (for dysmenorrhea and migraine attacks - up to 200 mg/day). When taking 100 mg retard, if it is necessary to increase the daily dose to 150 mg, you can additionally take 1 regular tablet (50 mg). IV drip. The maximum daily dose is 150 mg. Immediately before intravenous administration, diclofenac (contents of 1 ampoule - 75 mg) should be diluted in 100-500 ml of 0.9% NaCl solution or 5% dextrose solution (after adding sodium bicarbonate solution to the infusion solutions - 0.5 ml 8.4% or 1 ml 4.2% solution). Depending on the severity of the pain syndrome, the infusion is carried out for 30-180 minutes. In order to prevent postoperative pain, an infusion is carried out with a “shock” dose of the drug (25-50 mg over 15-60 minutes). Subsequently, the infusion is continued at a rate of 5 mg/hour (until the maximum daily dose of 150 mg is reached). For the treatment of acute conditions or relief of exacerbation of a chronic disease, intramuscular (single) administration is also possible; further treatment is continued with oral diclofenac, taking into account the maximum daily dose of 150 mg (including on the day of injection). The injection solution is injected deep intramuscularly for no more than 2 weeks. Rectally, 50 mg 2 times a day or 100 mg 1 time a day. Migraine attack - rectal suppositories in a dose of 100 mg at the first signs of an attack. If necessary, repeat 100 mg.

Special instructions:

In order to quickly achieve the desired therapeutic effect, take 30 minutes before meals. In other cases, take before, during or after meals, unchewed, with a sufficient amount of water. Because of the important role of Pg in maintaining renal blood flow, special caution should be exercised when prescribing to patients with heart or renal failure, as well as when treating elderly patients taking diuretics, and patients who, for any reason, have a decrease in blood volume (for example, after a major surgical intervention). If diclofenac is prescribed in such cases, monitoring of renal function is recommended as a precaution. In patients with renal failure with CC less than 10 ml/min, the Css of metabolites in plasma should theoretically be significantly higher than in patients with normal renal function, but this is not actually observed, since in this situation the excretion of metabolites in the bile is enhanced. In patients with liver failure (chronic hepatitis, compensated cirrhosis of the liver), the kinetics and metabolism do not differ from similar processes in patients with normal liver function. When carrying out long-term therapy, it is necessary to monitor liver function, peripheral blood patterns, and stool analysis for occult blood. During the treatment period, the speed of mental and motor reactions may decrease, so it is necessary to refrain from driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Interaction:

Increases plasma concentrations of digoxin, methotrexate, Li+ drugs and cyclosporine. Reduces the effect of diuretics; against the background of potassium-sparing diuretics, the risk of developing hyperkalemia increases; against the background of anticoagulants, antiplatelet and thrombolytic drugs (alteplase, streptokinase, urokinase), the risk of bleeding increases (usually the gastrointestinal tract). Reduces the effect of antihypertensive and hypnotic drugs. Increases the likelihood of side effects of other NSAIDs and corticosteroids (bleeding in the gastrointestinal tract), the toxicity of methotrexate and the nephrotoxicity of cyclosporine. ASA reduces the concentration of diclofenac in the blood. Concomitant use with paracetamol increases the risk of developing nephrotoxic effects of diclofenac. Reduces the effect of hypoglycemic drugs. Cefamandole, cefoperazone, cefotetan, valproic acid and plicamycin increase the incidence of hypoprothrombinemia. QT Cyclosporine and Au preparations increase the effect of diclofenac on Pg synthesis in the kidneys, which is manifested by increased nephrotoxicity. Simultaneous administration with ethanol, colchicine, corticotropin and St. John's wort preparations increases the risk of bleeding in the gastrointestinal tract. Drugs that cause photosensitivity increase the sensitizing effect of diclofenac to UV irradiation. Drugs that block tubular secretion increase the plasma concentration of diclofenac, thereby increasing its effectiveness and toxicity.

Side effects

Gastrointestinal tract: peptic ulcers, flatulence, constipation, dyspeptic disorders, diarrhea syndrome, cramps, abdominal pain, increased liver enzymes, gastrointestinal bleeding, perforation , dry mouth, aphthous stomatitis , esophageal damage, blood in the stool, melena , jaundice, hepatorenal syndrome , hepatitis, liver cirrhosis, hepatonecrosis, colitis, pancreatitis, perversion of taste perception.

Nervous system: anxiety, headache, weakness throughout the body, diplopia, depression, drowsiness, sleep disturbances, convulsions, aseptic meningitis .

Sense organs: scotoma , possible irreversible decrease in auditory perception, blurred visual perception, taste disturbances.

Skin: itching, rash, eczema , urticaria , alopecia, Lyell's syndrome, Stevens-Johnson syndrome , toxic dermatitis, photosensitivity.

Genitourinary system: proteinuria , nephrotic syndrome , fluid retention in the body, azotemia, papillary necrosis, acute renal failure, interstitial nephritis , oliguria. Hematopoietic organs: the development of anemia, eosinophilia, leukopenia, thrombocytopenic purpura, and agranulocytosis is rarely observed.

Respiratory system: laryngeal edema, cough, development of bronchospasm. Cardiovascular system: congestive heart failure, increased blood pressure.

Allergic responses: swelling of the tongue and lips, anaphylactic shock, anaphylactoid reactions.

What is better Ortofen or Ibuprofen?

Ibuprofen is a drug from the group of non-steroidal anti-inflammatory drugs (NSAIDs). The product is not addictive. It has an anti-inflammatory effect on the body, relieves pain and lowers body temperature. The main active ingredient is ibuprofen. It inhibits cyclooxygenase in both isoforms (COX-1 and COX-2). The analgesic effect is due to inhibition of prostaglandin synthesis in the central and peripheral nervous system. Ibuprofen inhibits platelet aggregation.

The medication is available in several forms:

• film-coated tablets;
• gelatin capsules;
• gel (50 mg of active ingredient per 1 g of drug);
• ointment 5%;
• suspension for children (20 mg of ibuprofen per 1 g of drug);
• rectal suppositories.

Ibuprofen is prescribed for:

• joint pain;
• symptoms of a pinched nerve in the lower back;
• fever against the background of the development of colds
• menstrual pain;
• toothache.

When using an ointment or gel, you need to rub the drug into the affected area of ​​the skin. This will increase the effectiveness of the product. The drug should not be taken internally if you have kidney or liver disease or a stomach ulcer. Hypersensitivity to the components of the drug is an indirect contraindication.

Instructions for use of Ortofen (Method and dosage)

Ortofen tablets, instructions for use

The tablets are not chewed, taken orally after meals.

The dosage for adults is 25-50 mg 2-3 times a day. The amount of the drug is gradually reduced when the required therapeutic result is achieved, after which they switch to a maintenance dose of 50 mg/day.

When treating rheumatoid juvenile arthritis, the daily amount of the drug can be increased to 3 mg/kg.

Ortofen injections, instructions for use

A single intramuscular injection of the drug is acceptable to relieve exacerbations of chronic diseases, and subsequently switch to taking oral forms. The medicine is injected intramuscularly at a dose of 75 mg.

Ortofen ointment, instructions for use

Apply about 3 g of ointment to the sore spot in a thin layer. A maximum of 8 g of the product should be applied externally per day.

For what diseases is it taken?

Ortofen is used for symptomatic treatment in the presence of such conditions

:

• inflammation and degenerative-dystrophic pathologies in joint tissue;
• inflamed swelling of soft tissue;
• rheumatoid arthritis;
• osteoarthritis;
• painful manifestations in the spinal column (ankylosing spondylitis, spondyloarthritis);
• damage to fibers in ligamentous and muscle tissue, as well as tendons;
• acute attacks of gout;

• inflammatory gynecological diseases accompanied by painful manifestations (primary dysmenorrhea, adnexitis);
• pain after injury and surgery, swelling and inflammation resulting from orthopedic or dental surgery;
• infectious and inflammatory pathology of ENT organs;
• muscle and joint pain caused by physical overload

Ortofen can be prescribed according to the instructions even in cases where the patient has suffered severe stress on the muscles.

Overdose

Manifested by myoclonic convulsions , epigastric pain, disturbances in the liver and kidneys, bleeding, clouding of consciousness, hyperventilation of the pulmonary system, headaches and dizziness.

Gastric lavage, emergency administration of enterosorbents , and syndromic therapy are required. Forced diuresis and hemodialysis have not proven their effectiveness and are not used.

How does Ortofen work?

The mechanism of action of all forms of the drug is determined by the non-steroidal anti-inflammatory active component they contain. The injection solution and tablets have a systemic effect, relieve symptoms of fever and acute pain. Diclofenac indiscriminately inhibits the activity of pain and inflammatory prostaglandins, has an antiplatelet property - it increases blood flow. After administration intramuscularly or orally, the medicine is distributed in all fluids and tissues of the body. The liver and kidneys take part in the transformation and filtration of drug metabolites.

Topical preparations: Ortofen ointment and gel have moderate analgesic properties and are used to reduce pain in muscles and joints. Part of the drug is absorbed orally through the skin. With prolonged use, the active substance may accumulate in the blood and affect the tissues of internal organs.

Interaction

Ortofen is able to increase the level of cyclosporine , digoxin, lithium preparations, methotrexate in the blood. The drug reduces the severity of the effect of diuretics, increases the likelihood of bleeding when taking alteplase, urokinase, streptokinase, antiplatelet and anticoagulant drugs. There is a decrease in the effectiveness of sleeping pills and antihypertensive drugs.

The medication increases the nephrotoxicity of cyclosporine, enhances the toxic effect of methotrexate, and increases the severity of side effects of glucocorticosteroids and other NSAID medications. It is not recommended to prescribe simultaneously with paracetamol.

The drug reduces the effectiveness of hypoglycemic agents . Valproic acid , cefotetan, cefamandole, plicamycin, cefoperazone increase the likelihood of developing hypoprothrombinemia .

St. John's wort, corticotropin, ethanol and colchicine significantly increase the risk of gastrointestinal bleeding .

Medicines that, by their mechanism of action, cause blocking of tubular secretion, can increase the level of the main substance in the blood, which increases the toxicity and effectiveness of the drug Ortofen.

Interaction with other drugs

If your doctor has prescribed Ortofen for you, be sure to inform him of what other substances you need to take during the course of treatment, so that the doctor can assess the possibility of drug compatibility and adjust the dosage or prescribe substitutes. When taking Ortofen and some drugs containing lithium together, an overdose of lithium in the blood plasma is possible, and the same problems can arise when Digoxin is prescribed. In this case, a specialist must constantly monitor the content of the substance in the blood by conducting tests.

Concomitant use with diuretics can lead to problems with blood pressure and cause impaired kidney function.

Warfarin may cause bleeding. Use together with morphine usually affects the concentration of the metabolite, and combined use with Pentazocine is also undesirable in order to avoid seizures.

Ceftriaxone combined with diclofenac can cause gallbladder disorders. The doctor will advise you on what to replace one of the necessary medications to eliminate harmful effects on the body. When considering compatibility with alcohol, it should be noted that interactions may negatively affect the stomach and intestines, so avoid drinking alcohol during treatment.

special instructions

Ortofen can be taken half an hour before meals to achieve a faster therapeutic effect. In other cases, the drug is recommended to be taken before, during, or after meals. Tablet dosage forms are not chewed and washed down with the required amount of liquid.

an important role in maintaining renal blood flow , which requires the doctor to have a special attitude towards patients with pathologies of the renal and cardiac systems, as well as persons taking diuretics with a reduced volume of circulating blood. Long-term therapy requires periodic monitoring of liver function and the state of peripheral blood ; it is recommended to conduct regular stool tests for occult blood.

Ortofen affects the course of certain motor and mental reactions, therefore it is recommended to refrain from driving vehicles and performing complex work during the period of treatment with diclofenac.

What helps better than Ortofen ointment

When it is planned to choose Ortofen as the main means of treating diseases of the musculoskeletal system, analogues should also be considered. Medicines in this group affect hard and soft tissues. However, Ortofen has a number of contraindications, which narrows its scope of application. For this reason, it is recommended to consider analogues - drugs that are similar in principle of action or composition. Some of them are offered at a high price, others are cheaper.

Naklofen SR

This drug is in tablet form. It can be purchased for an average of 90 rubles. For comparison, Ortofen is offered in the same form (in addition to gel, ointment, injection solution), but the price is 40 rubles. In both cases, the package contains 20 tablets. The main component of Naklofen SR is diclofenac. The tablet contains 100 mg of this compound.

Diclonate P

Release form: solution for intravenous or intramuscular administration. Cost - 100 rubles for 5 ampoules. The active substance in the drug Diclonate P is diclofenac. The ampoule contains 75 ml.

Diclofenac Retard-Akrikhin

Available in tablet form. If different analogues of Ortofen are being considered, you should pay attention to Diclofenac Retard-Akrikhin. Its cost is much lower than most existing products and averages 45 rubles per package. The main active ingredient is diclofenac sodium. 1 tablet contains 100 mg of this compound.

Diclovit product

Available in gel form. Intended for external use, acts locally. It has been confirmed that medications in the form of a cream or gel are safer than injections, tablets and even suppositories, since they do not penetrate the circulatory system.

Ortofen's analogs

Level 4 ATC code matches:
Voltaren

Rapten

Zerodol

Dickloberl Retard

Dikloberl N 75

Dicloberl

Ketanov

Dolak

Panoxen

Ketorolac

Naklofen Duo

Naklofen

Olfen-100

Olfen-75

Neurodiclovit

Nizilat

Fanigan

Aertal

Methindol retard

Analogs are the following drugs: Almiral , Argett , Bioran , Voltaren , Diklak , Dicloberl , Diclovit , Dicloran , Diclorapid , Dicloreum , Diclofenac , Diclofenac Sodium , Naklofen , Nergez , Olfen , Feloran , Evinopon .

Reviews about Ortofen

The tablets quickly and effectively help relieve pain and inflammation and reduce fever. The drug is effective for otitis, bursitis, inflammation of the joints, and is a good pain reliever for arthritis.

The downside is that it has a bad effect on the stomach, which can lead to ulcers. The medicine also has a large number of contraindications.

Reviews of Ortofen ointment also testify in favor of this remedy. The medicine instantly relieves pain and relieves inflammation in problem areas.

What does Ortofen ointment help with?

The active element of this ointment has powerful analgesic and anti-inflammatory effectiveness. Capable of reducing temperatures. In diseases of the rheumatoid type, it quickly reduces pain in the joints that occurs both in a quiet position of the body and during movement. At the same time, morning stiffness and swelling in the joint tissues are reduced, and motor volume is naturally stimulated. The desensitizing effect is observed with long courses of ointment.

Another property of the ointment is that it is antipyretic, helping to reduce the temperature accompanying inflammation.

The drug is a pronounced anesthetic and relieves pain caused by compression of nerve endings during tissue inflammation. Penetrates the intra-articular fluid and normalizes its composition. This allows Ortofen to be used for rheumatic lesions.

The ointment is used for inflammatory processes of various localizations, degenerative conditions of the spine and joints, consequences of injuries and damage. What does using the drug help with:

• diseases of the spine - osteochondrosis, radiculitis, sciatica, lumbago;
• joint pathologies - gouty, rheumatoid arthritis, arthrosis, spondyloarthritis;
• injuries and inflammation of soft tissues and tendons;
• postoperative pain;
• muscle pain of a neuralgic nature;
• relieving pain and swelling caused by excessive exercise.

Ortofen helps well with occupational diseases (in particular, with periatropathy of the shoulder joint or tennis elbow) and bone fatigue syndrome for people who often perform the same type of movements and overexert their muscles. These are musicians, athletes, industrial workers.

Ortofen price, where to buy

The price of Ortofen in tablets is approximately 40 rubles.

The price of Ortofen injections starts from 40 rubles per pack of 10 ampoules of 3 ml.

The price of Ortofen ointment is 30-60 rubles per 30 g.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

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• Ortofen gel for external use. approx. 5% 50gVertex JSC

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Pharmacy Dialogue

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• Ortofen 0.025 g No. 30 tablets PAT "Vitamin" Ukraine
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Ortofen and Diclofenac: what is the difference?

For severe chronic pain, effective drugs are Ortofen or Diclofenac. Medicines have similar properties, so it is difficult to choose which drug is better. Medicines are presented in the form of tablets, ointments, gels, and solutions for intramuscular administration. Ortofen contains acids that not only eliminate inflammation, but also normalize body temperature during hyperthermia. Ortofen is approved for external use in children over 6 years of age. It can be prescribed during pregnancy, but in the 3rd trimester the use of the drug in any dosage form is contraindicated.

For severe chronic pain, effective drugs are Ortofen or Diclofenac.

Considering the risks for the expectant mother and the effect of the active substance on the development of the fetus, Diclofenac is prescribed with caution. Injections should not be done every day; it is better to carry out the procedure for no more than 2 days, and then use tablets, suppositories, gel or ointment. Injections negatively affect the production of bile and the functioning of the gastrointestinal tract. The cost of Diclofenac in tablets is within 72 rubles, Ortofen in tablets can be purchased at a price of 50 rubles.

Medicines are sold without a prescription. But before you start taking the drug in tablets, you need to consult your doctor. Ointments and gels do not have a negative effect on the skin, so they can be used without a doctor’s prescription.