Kalcemin (Kalcemin Silver, Citra-Kalcemin): instructions for use, price and reviews during pregnancy

Composition of Kalcemin

1 tablet contains calcium citrate and - 0.25 g, vitamin D3 (cholecalciferol) - 50 IU, zinc - 2 mg, manganese sulfate - 500 mcg, boron - 50 mcg, copper - 500 mcg.
Additional substances: microcrystalline cellulose, stearic acid, maltodextrin , magnesium stearate , crocscarmellose ; The shell contains the following composition: hypromellose , silicon and titanium dioxide, magnesium silicate, mineral oil.

Calcemin Silver contains calcium 500 mg, vitamin D3 – 400 IU, magnesium 40 mg, copper oxide – 1 mg, manganese 1.8 mg, boron – 250 mcg, zinc 7.5 mg.

Citra-Calcemin contains calcium in the form of citrate - 250 mg, vitamin D3 - 125 IU, magnesium 40 mg, boron - 0.25 mg, manganese - 0.5 mg, zinc - 3.75 mg, copper - 0.5 mg.

Calcemin Advance No. 30 film-coated tablets.

Calcemin Advance No. 30 film-coated tablets.

Composition of the drug active ingredients: 1 tablet contains: calcium (calcium carbonate, calcium citrate) 500 mg, vitamin D3 (cholecalciferol) 200 IU, magnesium (magnesium oxide) 40 mg, zinc (zinc oxide) 7.5 mg, copper (oxide copper) 1 mg, manganese (manganese sulfate) 1.8 mg, boron (sodium borate) 250 mcg; excipients: maltodextrin, microcrystalline cellulose, croscarmellose sodium, acacia, hypromellose, stearic acid, soy polysaccharide, titanium dioxide (E 171), sodium lauryl sulfate, magnesium silicate, triacetin, mineral oil, special red AC (E 129), sunset yellow FCF (E 110), brilliant blue FCF (E 133).

Dosage form Film-coated tablets. Oval tablets, pink coated with a transverse notch on one side. Pharmacotherapeutic group Calcium in combination with vitamin D and/or other drugs. ATC code 12 X. Calcium is an important structural component of bone tissue. Calcium supplementation corrects dietary calcium deficiency, especially in cases of increased need or decreased absorption. Calcium carbonate is the salt with the highest elemental calcium content. Calcium citrate increases the bioavailability of the drug in patients with reduced acidity of gastric contents, achlorhydria, while taking H2-histamine receptor blockers; reduces the risk of stone formation in the urinary tract with long-term use, has a high antiresorptive potential due to inhibition of parathyroid hormone. Vitamin D is very important for the absorption of calcium, phosphate and magnesium in the small intestine. It regulates the content of these elements in body fluids and helps maintain normal calcium levels in the blood, and is also involved in the synthesis of organic elements and skeletal calcification. Magnesium is involved in bone metabolism, prevents bone demineralization, and inhibits calcium deposition in the walls of blood vessels, heart valves, muscles, and urinary tract. Zinc is a cofactor for more than 200 enzymes and influences the process of bone tissue remodeling. Copper takes part in the construction of the most important connective tissue proteins - collagen and elastin, which form the matrix of bone and cartilage tissue. Manganese normalizes the synthesis of glycosaminoglycans necessary for the formation of bone and cartilage tissue. Duplicates the calcium-sparing functions of vitamin D. Boron regulates the activity of parathyroid hormone and, through it, the metabolism of calcium, magnesium, phosphorus and cholecalciferol.

Indications for use To slow down the rate of bone loss and correct calcium metabolism disorders, for the treatment of diseases of the musculoskeletal system and dental diseases. Recommended for children over 12 years of age, adults, including women in the peri- and postmenopausal period, especially if there are contraindications to the use of hormone replacement therapy. As part of complex treatment of conditions accompanied by significant loss of bone tissue mass. As a basic agent when using antiresorbents (hormone replacement therapy, calcitonin, bisphosphonates) and stimulators of bone tissue formation. Osteopenic conditions, systemic osteoporosis and its complications.

Contraindications Increased individual sensitivity to any of the components of the drug (allergic reactions); hypercalcemia and/or conditions leading to hypercalcemia (sarcoidosis, malignancies and primary hyperthyroidism), severe hypercalciuria, renal dysfunction, nephrolithiasis; hypervitaminosis D Appropriate safety precautions for use Do not exceed the recommended dose. Calcemin Advance should not be used simultaneously with other calcium or vitamin D preparations. An overdose of calcium and vitamin D is accompanied by side effects, including hypercalcemia and hypercalciuria. Calcium and vitamin D should be used with caution so as not to exceed a total dose of 2500 mg calcium and 4000 IU vitamin D, taking into account dietary intake (see section "Overdose"). Patients who are receiving other drugs containing vitamin D and/or calcium or any other drugs should consult their doctor before using this drug. During long-term treatment with drugs containing calcium in combination with vitamin D, as well as in patients with mild or moderate renal impairment (including elderly patients), it is necessary to monitor the level of calcium, phosphate and creatinine in the blood serum; calcium and phosphates - in the urine. If signs of hypercalcemia or impaired renal function or calciuria exceeding 7.5 mmol/day (300 mg/day) appear, the dose should be reduced or the drug should be discontinued. In patients with impaired renal function and with the simultaneous use of cardiac glycosides, calcium channel blockers and/or thiazide diuretics, monitoring of the functional state of the kidneys should be carried out by determining the level of creatinine in the blood serum (see section “Interaction with other drugs and other types of interactions”). . Combination drugs should be used with caution in immobilized patients due to the increased risk of hypercalcemia. Use during pregnancy and lactation During pregnancy and lactation, the drug is used according to indications and under the supervision of a physician. The use of the drug in recommended doses is considered safe. Recommended doses should not be exceeded as chronic overdose may be harmful to the fetus and newborn. Hypercalcemia in the expectant mother during pregnancy due to the use of increased doses of vitamin D can lead to the development of side effects in the fetus: suppression of parathyroid hormone, hypocalcemia, tetany, epileptic seizures and aortic stenosis syndrome, the symptoms of which may be retinopathy, mental retardation or growth impairment; and also lead to the development of hypercalcemia in newborns. Vitamin D and calcium are excreted into breast milk. This should be taken into account if the child is receiving any appropriate supplements. To date, there is no evidence to suggest that vitamin D and/or calcium may have an adverse effect on fertility in humans.

The ability to influence the reaction rate when driving a vehicle or working with other mechanisms Does not affect.

Children Not intended for use by children under 12 years of age.

Directions for use and dosage: Adults and children over 12 years of age, take 1 tablet with meals 1-2 times a day. In case of significant loss of bone tissue, the dose can be increased to 3 tablets per day. The course of treatment is determined by the doctor depending on the nature of the disease.

Overdose When used in recommended doses, no cases of overdose were observed. In case of accidental overdose, symptomatic treatment is recommended: gastric lavage, drinking plenty of fluids, and a diet low in calcium. Total intake of calcium and vitamin D in doses exceeding 2500 mg calcium and 4000 IU/day vitamin D may cause toxic effects. In patients with hypercalcemia or conditions associated with hypercalcemia, renal failure and/or a tendency to nephrolithiasis, toxic effects of calcium and vitamin D are likely to occur when low doses are used. Acute or long-term overdose of calcium and vitamin D can cause hypervitaminosis D, hypercalcemia, hypercalciuria and hyperphosphatemia. The consequences are renal failure, “milk-alkali syndrome”, calcification of blood vessels and soft tissues, including calcification, leading nephrocalcinosis to nephrolithiasis. Nonspecific primary symptoms such as sudden onset of headache, muscle weakness, depression of consciousness and gastrointestinal disturbances (abdominal pain, constipation, diarrhea, nausea and vomiting) may indicate acute overdose. If such symptoms occur, you should stop using the drug and consult a doctor. Laboratory and clinical manifestations of poisoning and hypercalcemia may include symptoms such as anorexia, weight loss, fatigue, thirst, polyuria, bone pain, cardiac arrhythmias, and impaired absorption of other minerals. Changes in laboratory data may include an increase in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in the blood plasma. Chronic overdose can cause calcification of blood vessels and organs due to hypercalcemia. Extremely high hypercalcemia can lead to coma and death.

Side effects From the gastrointestinal tract. Gastrointestinal and abdominal pain, dyspepsia (including abdominal discomfort), constipation, diarrhea, flatulence, nausea and vomiting. From the immune system (allergic reactions, anaphylactic reactions, anaphylactic shock). Rarely, hypersensitivity reactions have been reported, accompanied by associated laboratory and clinical manifestations, including asthma syndrome, mild to moderate reactions affecting the skin and/or respiratory system, gastrointestinal tract and/or cardiovascular system. Symptoms may include rash, urticaria, swelling, redness of the skin, itching, and noncardiogenic pulmonary edema. Severe reactions, including anaphylactic shock, have been reported very rarely. From the laboratory data point of view. With long-term use in high doses, the development of hypercalcemia, hypercalciuria, hypervitaminosis D is possible. Interaction with other drugs and other types of interactions When using this drug simultaneously with other drugs, you should consult your doctor. Interaction with other drugs. Calcium may reduce the absorption of other drugs (including antibiotics (eg, tetracyclines, quinolones) and antivirals, protease inhibitors, eltrombopag) from the gastrointestinal tract. This may also reduce calcium absorption. To prevent potential interactions, wait at least 2 hours before or 4 to 6 hours after consuming calcium between use of these drugs, unless otherwise directed. Levothyroxine should be used at least 4 hours before or 4 hours after calcium intake; Phosphates, bisphosphonates and fluorides should be taken at least 30 minutes before calcium, but preferably at another time or day. Concomitant use of the drug with antacids containing aluminum is not recommended due to a decrease in their effectiveness. Calcium and/or vitamin D. Thiazide diuretics reduce urinary calcium excretion. Due to the increased risk of hypercalcemia when thiazide diuretics are used concomitantly, serum calcium levels should be monitored regularly. When used simultaneously with furosemide and other “loop” diuretics, calcium excretion by the kidneys increases. Cardiac glycosides and calcium channel blockers: Hypercalcemia increases the risk of fatal arrhythmias with cardiac glycosides such as digoxin and reduces the effectiveness of calcium channel blockers such as verapamil for atrial fibrillation. It is recommended to monitor serum calcium levels, ECG and the patient's clinical condition. Glucocorticoids and hormonal contraceptives impair the absorption of calcium ions. Vitamin D: Some medications may reduce the absorption of vitamin D from the gastrointestinal tract. In order to minimize interactions, these drugs and vitamin D should be taken at least 2 hours before or 4-6 hours after taking vitamin D. Such drugs include: ion exchange resins (for example, cholestyramine), laxatives, orlistat. Carbamazepine, phenytoin or barbiturates increase the metabolism of vitamin D to its inactive metabolites and thus reduce its effect. With simultaneous use of the drug Calcemin Advance with vitamin A, the toxicity of vitamin D3 is reduced. Interaction of calcium with food and supplements. Oxalic acid, found in spinach and rhubarb, and phytic acid, found in whole grains, can inhibit calcium absorption. Therefore, it is not recommended to consume foods containing calcium within two hours after eating food rich in oxalic and phytic acid.

Shelf life: 3 years. Do not use the drug after the expiration date indicated on the package.

Storage conditions No special storage conditions are needed. Store in a tightly sealed bottle. Keep out of the reach of children.

Packaging Primary: plastic bottle containing 30, 60 or 120 film-coated tablets with a screw cap and protective film. Secondary: cardboard box.

Dispensing category Without a prescription.

Instructions for use of Calcemin (Method and dosage)

Children over 12 years of age and adults - 2 tablets per day in 2 divided doses.

Children from 5 to 12 years old take 1 tablet. per day.

Take the medicine with food.

If there is a lack of trace elements and calcium in the body, use 1 tablet per day.

The instructions for Kalcemin provide clear instructions on how to take the medicine for pregnant women: use begins in the 2nd half of pregnancy (not earlier than the 20th week ) and continues throughout breastfeeding at a dose of 1 tablet twice a day.

The instructions for Citra-Calcemin indicate that the drug is a dietary food supplement and is not a drug.

Interactions of the drug Calcemin silver

With simultaneous use of the drug Kalcemin Silver with vitamin A, the toxicity of vitamin D3 is reduced. Phenytoin, barbiturates, corticosteroids reduce the effectiveness of vitamin D3. Laxatives reduce the absorption of vitamin D3. GCS, hormonal contraceptives for systemic use, levothyroxine impair the absorption of calcium ions. When using tetracyclines simultaneously, the interval between doses should be at least 3 hours, bisphosphonates and sodium fluoride (their absorption is impaired) - at least 2 hours. When using the drug Calcemin Silver in combination with cardiac glycosides, their toxicity increases (monitoring of the ECG and clinical condition is necessary), with thiazide diuretics - the risk of developing hypercalcemia increases; with furosemide and other loop diuretics - the excretion of calcium by the kidneys increases. Calcemin Silver should not be used simultaneously with calcium channel blockers. It is not recommended to take the drug in combination with antacids containing aluminum due to a decrease in their effectiveness.

Analogues of Kalcemin

There are no structural analogues. Preparations with a similar composition: Beresh Calcium plus D3 , Calcium D3 Nycomed , Osteokea , Vitrum Calcium D3 .

The price of analogues ranges from 269 rubles. up to 581 rub. depending on the manufacturer and quantity in the package.

Calcemin or Calcium D3 Nycomed – which is better?

Calcium D3 Nycomed contains a higher dosage of vitamin D3 and calcium, but there are no additional microelements (zinc, boron, copper, magnesium). It also contains aspartate , which is not recommended for pregnant women. The cost of the drugs is practically the same.

What is the difference between Calcemin and Calcemin Advance?

The difference lies in the larger dose of the main components in Advance . For example, there is 2 times more calcium, and 4 times more vitamin D3.

Use during pregnancy and breastfeeding

During pregnancy and breastfeeding, taking the drug should be agreed with your doctor. The daily dose for pregnant women should not exceed 1500 mg of calcium and 600 IU of vitamin D3, because hypercalcemia, which develops against the background of an overdose during pregnancy, can cause defects in the mental and physical development of the child.

In nursing women, it should be taken into account that colecalciferol and its metabolites pass into breast milk. This should be taken into account when additionally prescribing calcium and vitamin D3 to a child.

Reviews about Kalcemin

There are many reviews that these are good vitamins for hair and nails. By taking the drug, you can perfectly strengthen flaking and thin nails, as well as accelerate hair growth. Many people use the medicine if they have to take medications for a long time that wash away calcium from the bones.

Numerous reviews of Calcemin during pregnancy indicate that it can actually prevent tooth decay and replenish calcium deficiency. In general, reviews from doctors indicate that the drug has become widespread among them for use during pregnancy in order to prevent muscle cramps in pregnant women and calcium deficiency in both mother and child. Moreover, this is perhaps the only calcium supplement that does not contain aspartame , an excess of which can cause a decrease in intelligence in children, and therefore is also safe for the child.

There are also positive reviews about Kalcemin Silver as a drug that has a good effect in healing fractures .

There are not very many reviews on Citra-Calcemin, but mostly good, as a drug for strengthening hair and nails. The disadvantage is the large size of the tablets, which are difficult to swallow or chew.

Indications for use of the drug Kalcemin silver

Complex treatment of osteoporosis of various origins: menopausal, senile, idiopathic, steroid, caused by prolonged immobilization, etc. and its complications (fractures, etc.), as well as severe dental and periodontal diseases. It is recommended as a means of basic therapy when using antiresorbents (hormone replacement therapy, calcitonin, bisphosphonates) and stimulators of bone tissue formation. To reduce the risk of fractures due to deficiency of calcium, vitamin D, and minerals in the diet of elderly people.

Calcemin price, where to buy

The cost of the drug in Russia depends on packaging - the price of 30 pieces ranges from 178 to 227 rubles, 60 tablets costs 274 - 348 rubles, and for a package of 120 tablets you need to pay from 422 to 494 rubles.

How much does the medicine cost in Moscow? Average price 30 pcs. 192 rubles, and a bottle with 120 tablets. costs 456 rubles.

In Ukraine you can buy Kalcemin Silver for 64 UAH. 30 tablets for 100 UAH. 120 tablets.

The average price of Citra-Calcemin is 43 UAH. 30 pieces and 62 UAH. 60 tablets.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine
Online pharmacies in KazakhstanKazakhstan

ZdravCity

Calcemin tablets p.p.o.
30 pcs. Sagmel Inc/Contract Pharmacal Corporation RUR 324 order
Calcemin Advance tablets p.p.o. 60 pcs. Sagmel Inc/Contract Pharmacal Corporation
RUR 643 order
Calcemin tablets p.p.o. 120 pcs. Sagmel Inc/Contract Pharmacal Corporation
RUR 771 order
Calcemin Advance tablets p.p.o. 120 pcs. Contract Pharmacle Corporation
RUB 1,074 order

Pharmacy Dialogue

Calcemin Advance (table p/o No. 120)Contract
RUB 1,049 order
Calcemin Advance (tablet no. 60)Contract
RUR 677 order
Calcemin (tablet p/o No. 120)Contract
RUR 781 order
Calcemin (tablet. No. 30)Contract
RUB 345 order
Calcemin (tablet. No. 60)Contract
RUR 536 order

Pharmacy24

Citra-Calcemin N60 tablets Mission Famekl Company, USA
102 UAH.order
Citra-Calcemin N30 tablets Mission Famekl Company, USA
69 UAH order
Calcemin Advance N60 tablets Contract Pharmacal Corporation, USA
150 UAH order

PaniPharmacy

Citra-calcemin tablet. No. 30, Mission Pharmacal Company
78 UAH order
Citra-calcemin tablet. No. 60, Mission Pharmacal Company
122 UAH order
Calcemin Advance film-coated tablets No. 60, Contract Pharmacal Corporation
157 UAH order
Calcemin Advance film-coated tablets No. 30, Contract Pharmacal Corporation
95 UAH order

Overdose

Hypervitaminosis D3, hypercalcemia and hypercalciuria.

Symptoms: thirst, polyuria, loss of appetite, constipation, nausea, vomiting, dizziness, muscle weakness, headache, fainting, coma, fatigue, bone pain, mental disorders, nephrocalcinosis, abdominal pain, urolithiasis; in severe cases - cardiac arrhythmias. With long-term use in doses above 2500 mg of calcium - kidney damage, soft tissue calcification.

Treatment: if the first signs of overdose are detected, it is necessary to reduce the dose or stop using the drug and consult a doctor. In case of hypercalciuria exceeding 7.5 mmol/day (300 mg/day), it is necessary to reduce the dose or stop taking the drug. Rehydration, administration of loop diuretics (for example, furosemide), corticosteroids, calcitonin, bisphosphonates; in severe cases - hemodialysis. In case of accidental overdose, induce vomiting and rinse the stomach. Therapy is symptomatic.

Therapeutic effects of use

Calcium is good not only for teeth and bones, but also for hair and nails. The drug contains:

Calcium . Helps improve the condition of the skin. It also normalizes the functioning of the gastrointestinal tract (due to the normalization of the digestive system, absorption improves). In addition, calcium normalizes the acid-base balance (reduces acidity, which blocks the flow of oxygen into the body, including the scalp). The element is part of tissue fluid.
Vitamin D3 . Improves the condition of the skeletal system, muscles, and skin. Thanks to this vitamin, calcium is better absorbed by the body and begins to work faster.
Zinc has a beneficial effect on the hormonal system of women, so it is especially important during menopause.

After a course of taking Calcemin, the general condition also improves, as the body is saturated with vitamins.

Taking Calcemin for hair loss or deterioration in hair quality

Hair health depends not only on calcium, but also on a number of other elements. Therefore, to maintain your condition, you first need to eat properly and nutritiously.

But it is worth considering that an excess of vitamins can also lead to negative consequences. Therefore, when taking nutritional components, you need to observe moderation.

There is a large list of calcium-containing foods. But if it is not possible to create a complete diet, it is necessary to take calcium-based medications.

Calcemin is one of the leading medications prescribed for problems with the musculoskeletal system (bones, muscles and joints). It is recommended to take it only after consulting a doctor and undergoing examinations.

It must be taken into account that no vitamin complex will help if you adhere to bad habits, especially smoking.

Calcemin for hair loss is taken in the same course as for deterioration of the musculoskeletal system. For complete hair restoration, the minimum course of taking vitamins is 1.5 months.