Comparison of the effectiveness of Analgin and Baralgin M
The effectiveness of Analgin is quite similar to Baralgin M - this means that the ability of the drug substance to provide the maximum possible effect is similar.
For example, if the therapeutic effect of Analgin is more pronounced, then using Baralgin M even in large doses will not achieve this effect.
Also, the speed of therapy - an indicator of the speed of therapeutic action - Analgin and Baralgin M are approximately the same. And bioavailability, that is, the amount of a drug reaching its site of action in the body, is similar. The higher the bioavailability, the less it will be lost during absorption and use by the body.
Comparison of the effectiveness of Baralgin M and Pentalgin
The effectiveness of Baralgin M is quite similar to Pentalgin - this means that the ability of the drug substance to provide the maximum possible effect is similar.
For example, if the therapeutic effect of Baralgin M is more pronounced, then using Pentalgin even in large doses will not achieve this effect.
Also, the speed of therapy - an indicator of the speed of therapeutic action - Baralgin M and Pentalgin are approximately the same. And bioavailability, that is, the amount of a drug reaching its site of action in the body, is similar. The higher the bioavailability, the less it will be lost during absorption and use by the body.
Comparison of safety of Analgin and Baralgin M
The safety of a drug includes many factors.
At the same time, in Analgin it is quite similar to Baralgin M. It is important where the drug is metabolized: medicinal substances are excreted from the body either unchanged or in the form of products of their biochemical transformations. Metabolism occurs spontaneously, but most often involves major organs such as the liver, kidneys, lungs, skin, brain and others. When assessing the metabolism of Analgin, as well as Baralgin M, we look at which organ is the metabolizing organ and how critical the effect on it is.
The risk-benefit ratio is when the prescription of a drug is undesirable, but justified under certain conditions and circumstances, with the obligatory observance of caution in use. At the same time, Analgin does not have any risks when used, just like Baralgin M.
Also, when calculating safety, it is taken into account whether only allergic reactions occur or possible dysfunction of the main organs. In other matters, as well as the reversibility of the consequences of using Analgin and Baralgin M.
Comparison of Analgin and Baralgin
To determine which drug works better and more effectively, you must first compare them according to several basic criteria. Below is a comparative description of medicines.
Efficiency
Baralgin is more effective than Analgin. Although they have the same active ingredient, they act slightly differently. If you take Baralgin and Analgin in a certain therapeutic dose, the first will work more effectively. Even with an increased dosage of the second, it is not possible to achieve the same result.
Baralgin also “works” faster. Its active substance reaches the site faster and begins to inhibit the synthesis of prostaglandins.
Safety
Baralgin is safer. It accumulates in minimal quantities in target organs (kidneys, liver) and is quickly eliminated from the body naturally.
With Analgin, the elimination process is slower. In addition, a person more often experiences an allergic reaction to it - urticaria, bronchial asthma, anaphylactic shock and other manifestations.
Comparison of addiction between Analgin and Baralgin M
Like safety, addiction also involves many factors that must be considered when evaluating a drug.
So, the totality of the values of such parameters as “syndrome” in Analgin is quite similar to the similar values in Baralgin M. Withdrawal syndrome is a pathological condition that occurs after the cessation of the intake of substances that cause addiction or dependence into the body. And resistance is understood as initial immunity to a drug; in this it differs from addiction, when immunity to a drug develops over a certain period of time. The presence of resistance can only be stated if an attempt has been made to increase the dose of the drug to the maximum possible. At the same time, Analgin’s “syndrome” values are quite small, however, the same as for Baralgin M.
Baralgin: brief description of the drug
Baralgin is a drug classified as an antipyretic and analgesic. Included in the group of non-narcotic non-steroidal drugs. It has a pronounced antipyretic, analgesic and anti-inflammatory effect on the human body.
Release form and composition
The manufacturer produces the pharmaceutical drug in two dosage forms - tablets and solution for injection. Until 2009, Baralgin was registered in Russia, which included not 1, but 3 active ingredients - pitofenone, metamizole sodium and fenpiverinium bromide. But now in pharmacies you can also find a drug with 1 active chemical component - metamizole sodium.
Composition of Baralgin:
- active substance – metamizole sodium – 500 mg;
- magnesium stearate;
- macrogoal
Pharmacokinetics and pharmacodynamics
Metamizole is a pyrazolone derivative. The mechanism of action is based on inhibition of the synthesis of substances that are actively involved in the development of the inflammatory and pain process.
After taking Baralgin, the active substance is quickly absorbed in the digestive tract and is broken down into an active metabolite. With the bloodstream, it quickly penetrates into the pathological focus - about 60% of metamizole binds to plasma proteins.
Indications and contraindications
Baralgin is prescribed if a person has the following pathological conditions:
- spasm of smooth muscles of the gastrointestinal tract and intravenous system;
- pain syndrome of various origins;
- pain syndrome in the postoperative period;
- fever.
Not in all cases it is allowed to take the drug. So, Baralgin is prohibited for:
- severe pathologies of the liver and kidneys;
- hepatic porphyria;
- bronchial asthma;
- disruption of the hematopoietic process;
- acute allergic reaction to the components of the product;
- the patient's age is up to 15 years;
- when carrying a child and breastfeeding.
How to take the medicine
A single dose of the drug Baralgin, which can be taken without harm to health, is from 500 mg to 1 g. The frequency is 2-3 times a day. You can take up to 6 tablets (3 g) per day.
The tablets are drunk whole, do not chew. Drink with plenty of water.
Side effects
Baralgin is usually tolerated normally by people - adverse reactions occur extremely rarely. But in some cases, the following pathological conditions may still occur:
allergic reaction, up to anaphylactic shock;
- proteinuria;
- oliguria;
- leukopenia;
- thromphobitopenia;
- severe hypotension.
Any of these conditions requires calling a doctor or an ambulance. If anaphylactic shock develops, help should be provided immediately, as even death is possible.
Comparison of side effects of Analgin and Baralgin M
Side effects or adverse events are any adverse medical event that occurs in a subject after administration of a drug.
Analgin has more adverse events than Baralgin M. This implies that the frequency of their occurrence is low with Analgin and low with Baralgin M. Frequency of manifestation is an indicator of how many cases of an undesirable effect from treatment are possible and registered. The undesirable effect on the body, the strength of influence and the toxic effect of drugs are different: how quickly the body recovers after taking it and whether it recovers at all. When using Analgin, the body's ability to recover faster is higher than that of Baralgin M.
Analgin: brief description of the drug
Analgin is a drug that has anti-inflammatory, analgesic and antipyretic effects. Its mechanism of action is inhibition of the synthesis of prostaglandins - substances responsible for the inflammatory response in the body.
Form and composition
Analgin is produced in two dosage forms - tablets and solution for injection. The liquid is clear or slightly yellowish. The tablets are round, white.
Substances included:
- metamizole sodium – 500 mg;
- sucrose;
- calcium stearate;
- starch;
- talc;
- povidone;
- silicon dioxide
Analgin is included in the group of non-narcotic analgesic drugs
Pharmacokinetics and pharmacodynamics
Metamizole sodium is an active chemical substance that has three effects:
- analgesic;
- antipyretic;
- antispasmodic.
After oral administration, the tablet is quickly absorbed into the gastrointestinal tract. The effect of Analgin appears after a maximum of 40 minutes.
Indications and contraindications
You can take Analgin in a therapeutic dose to reduce the severity of pain and reduce fever in the following conditions:
- injuries;
- wounds;
- headache;
- toothache;
- elevated temperature due to infectious and other pathologies.
Contraindications for use:
- acute allergic reaction to the components of the drug;
- bronchial asthma;
- disruption of the hematopoietic process;
- congenital deficiency of glucose-6-phosphate dehydrogenase;
- pregnancy and lactation;
- child's age up to 15 years.
You can take it, but with caution and under the strict supervision of a doctor for the following pathologies:
- arterial hypotension;
- alcohol abuse;
- allergic reaction to alcohol-containing drinks;
- intolerance to preservatives and dyes, such as benzoates, tartrazine and others;
- disorders of the kidneys and liver.
How to take the medicine
To reduce unpleasant symptoms, first take the smallest dose of the drug. The same applies to the first dose of Analgin.
A single dose of a tablet drug for people weighing more than 53 kg is from 250 to 500 mg (a whole tablet or half of it). The maximum you can take per day is 2000 mg. Multiplicity – up to 3 times.
If Analgin is administered by injection, then the single dose is from 500 to 1000 mg. A maximum of 2000 mg can be administered per day. Multiplicity – 2-3 times.
Side effects
Undesirable effects that may occur when taking Analgin:
- anaphylactic shock;
- analgesic bronchial asthma;
- drug dermatitis;
- leukopenia;
- agranulocytosis;
- aplastic anemia;
- isolated arterial hypotension;
- disruption of the urinary system.
If you take Analgin in an increased dose, overdose symptoms may appear, such as:
- acute renal or liver failure;
- nausea and vomiting;
- decrease in body temperature;
- decrease in blood pressure;
- tachycardia;
- headache and dizziness;
- convulsions;
- paralysis of the muscles of the respiratory system.
If any of these conditions occur, you should immediately call an ambulance or consult a doctor.
Comparison of ease of use of Analgin and Baralgin M
This includes dose selection taking into account various conditions and frequency of doses. At the same time, it is important not to forget about the release form of the drug; it is also important to take it into account when making an assessment.
The ease of use of Analgin is approximately the same as that of Baralgin M. However, they are not convenient enough to use.
The drug ratings were compiled by experienced pharmacists who studied international research. The report is generated automatically.
Last update date: 2020-12-04 13:44:43
Comparison of safety of Baralgin M and Pentalgin
The safety of a drug includes many factors.
At the same time, in Pentalgin it is higher than in Baralgin M. It is important where the drug is metabolized: medicinal substances are excreted from the body either unchanged or in the form of products of their biochemical transformations. Metabolism occurs spontaneously, but most often involves major organs such as the liver, kidneys, lungs, skin, brain and others. When assessing the metabolism of Pentalgin, as well as Baralgin M, we look at which organ is the metabolizing organ and how critical the effect on it is.
The risk-benefit ratio is when the prescription of a drug is undesirable, but justified under certain conditions and circumstances, with the obligatory observance of caution in use. At the same time, Pentalgin has fewer risks when used than Baralgin M.
Also, when calculating safety, it is taken into account whether only allergic reactions occur or possible dysfunction of the main organs. In other matters, as well as the reversibility of the consequences of using Pentalgin and Baralgin M.
Comparison of side effects of Baralgin M and Pentalgin
Side effects or adverse events are any adverse medical event that occurs in a subject after administration of a drug.
Pentalgin has more adverse events than Baralgin M. This implies that the frequency of their occurrence is low with Pentalgin and low with Baralgin M. Frequency of manifestation is an indicator of how many cases of an undesirable effect from treatment are possible and registered. The undesirable effect on the body, the strength of influence and the toxic effect of drugs are different: how quickly the body recovers after taking it and whether it recovers at all. When using Pentalgin, the body’s ability to recover faster is higher than that of Baralgin M.
Comparison of addiction between Baralgin M and Pentalgin
Like safety, addiction also involves many factors that must be considered when evaluating a drug.
So, the totality of the values of such parameters as “syndrome o” in Baralgin M is quite similar to the similar values in Pentalgin. Withdrawal syndrome is a pathological condition that occurs after the cessation of intake of addictive or dependent substances into the body. And resistance is understood as initial immunity to a drug; in this it differs from addiction, when immunity to a drug develops over a certain period of time. The presence of resistance can only be stated if an attempt has been made to increase the dose of the drug to the maximum possible. At the same time, in Baralgin M the meaning of the “syndrome” is quite small, however, the same as in Pentalgin.