Instructions for use of DONA® (DONA) solution for intramuscular administration

Instructions for use

The desired result can be obtained only with the correct use of the drug. To learn more about its characteristics, familiarize yourself with the rules of use and possible complications, you should carefully study the attached instructions.

How to give injections correctly

To administer injections, you must have the appropriate skills. It is better if this is done by a specialist with a medical education. Dona is administered only intramuscularly. Intravenous use is prohibited. Before making the injection, the contents of an ampoule with a glucosamine solution in one syringe are mixed with an ampoule of solvent. The resulting liquid should be injected deep into the muscle. As a rule, the composition is injected into the buttock.

During preparation, the solution may acquire a slightly yellowish tint. There is no need to be afraid of this; the effectiveness of the product does not decrease.

It is recommended to combine injection use of Dona and oral administration (there are tablets of the same name and powder for oral use).

Dosage regimen and overdose

Intramuscular injections of Don are given three times a week for one to one and a half months. The dose for one injection is 3 ml (2 ml of solution with the active substance and 1 ml of solvent). The treatment regimen can be adjusted.

No dose adjustment is required in elderly patients.

No cases of drug overdose have been recorded.

Content

• Characteristics of Don (amp. 400 mg 2 ml No. 6)

Composition: 1 ampoule contains: crystalline glucosamine sulfate 502.

5 mg, incl.

h.

glucosamine sulfate 400 mg, sodium chloride 102.

5 mg.

Excipients: lidocaine hydrochloride - 10 mg, water for injection - 2 ml.

Solvent: diethanolamine - 24 mg, water for injection - up to 1 ml Pharmacological action: Dona® - has an anti-inflammatory and analgesic effect, replenishes endogenous glucosamine deficiency, stimulates the synthesis of proteoglycans and hyaluronic acid in synovial fluid; increases the permeability of the joint capsule, restores enzymatic processes in the cells of the synovial membrane and articular cartilage.

Promotes fixation of sulfur during the synthesis of chondroitinsulfuric acid, facilitates normal calcium deposition in bone tissue, inhibits the development of degenerative processes in joints, restores their function, reducing joint pain.

Indications for Use: - primary and secondary osteoarthritis; - osteochondrosis; - spondyloarthrosis.

Method of Use: Intramuscularly! The drug is not intended for intravenous administration.

Before use, mix solution B (solvent) with solution A (drug solution) in one syringe.

The prepared solution of the drug is administered intramuscularly, 3 ml (solutions A + B) 3 times a week for 4-6 weeks.

Injections of the drug can be combined with oral administration of the drug in powder to prepare an oral solution (sachets).

The duration and treatment regimen are prescribed individually.

Interaction: Compatible with NSAIDs, paracetamol and glucocorticosteroids.

Caution should be exercised when prescribing injections of the drug in combination with beta-blockers, digitoxin, ajmaline, amiodarone, verapamil, quinidine, procainamide, hexenal or sodium thiopental, MAO inhibitors, polymyxin B, hypnotics or sedatives, cimetidine.

Side Effects: The drug is well tolerated.

In some cases: flatulence, diarrhea, constipation, allergic reactions - urticaria, itching.

Due to the content of lidocaine in the drug, the following are possible: nausea, vomiting, drowsiness, diplopia, headache, dizziness, numbness of the tongue and oral mucosa, tremor, euphoria, disorientation, cardiac conduction disturbances.

Contraindications: - individual hypersensitivity to glucosamine, lidocaine hydrochloride and other components of the drug.

Due to the presence of lidocaine in the composition of the drug: - cardiac conduction disorders and acute heart failure; - history of epileptiform seizures; - severe dysfunction of the liver and kidneys; - pregnancy and lactation; - children under 12 years of age.

With caution: patients with chronic heart failure, arterial hypotension.

Caution should be exercised in patients with allergies to seafood (shrimp, shellfish).

Overdose: No cases of overdose have been reported.

Special Instructions: When using the drug in patients with impaired glucose tolerance, with severe liver and kidney failure, medical supervision is necessary.

Storage Conditions: Room temperature

How to inject medicine: instructions for intramuscular use

The effect of the drug is achieved only if the drug instructions for use are correctly followed and all instructions for the course of treatment from the attending physician are followed.

Rules for taking the drug:

1. The ampoules containing the active substance and the solvent are opened alternately. The contents of first one and then the second bottle are drawn into the syringe. Mix in a syringe into a clear, pale yellow liquid. This mixture is injected into the gluteal muscle.
2. The drug is administered intermittently: 3 times a week. The course of treatment is 4–6 weeks. A 3 ml syringe with a needle for intramuscular injections is suitable.
3. During lactation or pregnancy, women are not recommended to use the drug "Dona". Similar contraindications for children under 18 years of age.

To make the treatment more effective, it is recommended to take the drug in the form of powder or tablets simultaneously with injections.

The use of the drug should be strictly controlled by a doctor, since the first improvements should appear already in 2-3 weeks of the course. If there are no positive effects, it is necessary to reconsider taking the drug “Dona”.

Dona solution for intramuscular administration 200 mg/ml in 2 ml ampoules complete with solvent No. 6

Name

Don.

Description

Solution A is a clear, colorless liquid or a clear, light brown liquid that does not contain suspended particles; solution B is a clear, colorless liquid that does not contain suspended particles; solution A plus solution B is a light brown transparent solution that does not contain suspended particles.

Main active ingredient

Release form

Solution for intramuscular administration.

Dosage

200 mg / 1 ml 2 ml.

special instructions

pharmachologic effect

Other nonsteroidal anti-inflammatory and antirheumatic drugs. ATX code: M01AX05.

Pharmacodynamics

Mechanism of action. Glucosamine sulfate is a salt of the amino monosaccharide glucosamine, which is an endogenous component and preferred substrate for the synthesis of glycosaminoglycans and proteoglycans in articular cartilage and synovial fluid. Glucosamine sulfate inhibits the activity of interleukin-1 beta and other inflammatory mediators. Clinical efficacy and tolerability The safety and effectiveness of glucosamine sulfate has been confirmed in clinical trials with treatment durations (oral administration) of up to three years. Short- and medium-term clinical studies have shown that the effectiveness of glucosamine sulfate in relation to the symptoms of osteoarthritis is observed after 2-3 weeks of its use. However, unlike NSAIDs, glucosamine sulfate has a long-lasting effect, lasting from 6 months to 3 years. Clinical studies with daily administration of glucosamine sulfate for up to 3 years have shown gradual improvement in symptoms and slowing of structural changes in the joint, as demonstrated by radiography. Glucosamine sulfate demonstrated good tolerability during short-term and long-term courses of treatment. Evidence of the drug's effectiveness was demonstrated when taken for three months, with residual effects for two months after its discontinuation. The safety and effectiveness of the drug have also been confirmed in clinical trials for up to three years. Continuous treatment for more than 3 years cannot be recommended, since there are no safety data when taking glucosamine for more than 3 years.

Pharmacokinetics

Glucosamine is a relatively small molecule (molecular weight 179) that is readily soluble in water and hydrophilic organic solvents. Available information on the pharmacokinetics of intramuscularly administered glucosamine is limited. Absolute bioavailability is unknown. The volume of distribution is approximately 5 liters and the half-life after intravenous administration is approximately 2 hours. Approximately 38% of an intravenously administered dose is excreted unchanged in the urine.

Indications for use

Relief of symptoms (mild to moderate pain) of adequately diagnosed osteoarthritis of the knee.

Directions for use and doses

For intramuscular use! The drug is not intended for intravenous administration. Adult and elderly patients Before use, mix solution B (solvent 1 ml) with solution A (drug solution 2 ml) in one syringe. The prepared solution of the drug is administered intramuscularly in 3 ml or 6 ml (solution A - B) 3 times a week for 4-6 weeks. The presence of a yellowish color of the solution in ampoule A does not affect the effectiveness and tolerability of the drug. Injections of the drug can be combined with oral administration of the drug in powder form to prepare a solution. Glucosamine is not intended for the treatment of acute pain. Symptom relief (especially pain relief) may occur after only a few weeks of treatment, and in some cases even after a longer time. If no relief of symptoms occurs after 2–3 months of use, treatment should be reconsidered. Patients should consult a doctor if pain worsens after starting glucosamine. Dosage regimen for different categories of patents Elderly patients No dose adjustment is required. Patients with impaired renal and/or liver function In patients with impaired renal and/or liver function, no recommendations for dose adjustment exist, since relevant studies have not been conducted. Children and adolescents Glucosamine should not be used in children and adolescents under the age of 18 years, since there is no data on the safety and effectiveness of glucosamine in this category of patients.

Use during pregnancy and lactation

There are no data regarding the use of the drug in pregnant women or during breastfeeding, so use of the drug during pregnancy or breastfeeding is not recommended.

Impact on the ability to drive vehicles and other mechanisms

Studies regarding the effect of the drug on the ability to drive a car and other mechanisms have not been conducted. You should be careful when driving vehicles and performing work that requires attention. If you experience headache, drowsiness, fatigue, dizziness or visual impairment, driving or operating other machinery is not recommended.

Precautionary measures

It is necessary to consult a doctor to exclude the presence of joint disease, for which other treatment methods are provided. Cases of exacerbation of bronchial asthma symptoms have been described after starting to take glucosamine. Patients suffering from bronchial asthma should be informed about the possible worsening of symptoms of the disease. One dose of the drug contains 40.3 mg of sodium. This should be taken into account when prescribing to patients on a sodium-restricted diet. Patients with impaired glucose tolerance should use caution when taking glucosamine. For patients with diabetes mellitus, it is recommended that blood sugar levels be monitored and insulin requirements determined before and periodically during treatment. No specific studies have been conducted in patients with renal or hepatic impairment. The toxicological and pharmacokinetic profile of glucosamine does not suggest restrictions for these patients. However, the use of glucosamine in patients with severe hepatic or renal impairment should be carried out under medical supervision.

Interaction with other drugs

No specific drug interaction studies have been conducted. There is evidence of an enhanced effect of coumarin anticoagulants; therefore, more careful monitoring of coagulation parameters is necessary in patients simultaneously taking coumarin anticoagulants (for example, warfarin or acenocoumarol). Oral administration of glucosamine sulfate may increase the absorption of tetracyclines from the gastrointestinal tract, but the clinical significance of this interaction is small. It is acceptable to take steroidal or non-steroidal anti-inflammatory drugs simultaneously with glucosamine.

Contraindications

Individual hypersensitivity to the active substance or to any of the excipients. The drug should not be used by patients with allergies to shellfish, since the active substance (glucosamine) is obtained from the shells of mollusks and crustaceans. Pregnancy and breastfeeding period. The injection form of the drug contains the excipient lidocaine, which has the following contraindications: arrhythmia, acute heart failure, and hypersensitivity to lidocaine.

Compound

Solution A: each ampoule (2 ml) contains: active substance: crystalline glucosamine sulfate 502.5 mg (contains 400 mg glucosamine sulfate and 102.5 mg sodium chloride); excipients: lidocaine hydrochloride 10.0 mg, water for injection up to 2 ml. Solution B: ampoule volume (1 ml) contains: excipients: diethanolamine – 24.0 mg, water for injection up to 1 ml.

Overdose

Cases of overdose are unknown. In cases of overdose, symptomatic treatment should be carried out aimed at restoring water and electrolyte balance.

Side effect

To determine the frequency of adverse events, the following categories of their occurrence in patients were used: Very often (≥ 1/10) Often (≥ 1/100 to

Storage conditions

At a temperature not exceeding 25 °C. Keep out of the reach of children.

Buy Dona solution for intramuscular injection. 200 mg/ml in amp 2 ml in com. with solution (diethane, water for injection in amp 1 ml) in a pack. No. 6 in the pharmacy

Price for Dona solution for intramuscular injection. 200 mg/ml in amp 2 ml in com. with solution (diethane, water for injection in amp 1 ml) in a pack. No. 6

Instructions for use for Don solution for intramuscular injection. 200 mg/ml in amp 2 ml in com. with solution (diethane, water for injection in amp 1 ml) in a pack. No. 6

Drug interactions

According to Don's instructions, it can be used simultaneously with non-steroidal anti-inflammatory drugs, glucocorticosteroids and paracetamol. The drug reduces the absorption of chloramphenicol and semisynthetic penicillins, increases the absorption of tetracyclines, and also enhances the effect of coumarin anticoagulants.

Caution must be exercised when prescribing Dona injections simultaneously with digitoxin, beta-blockers, amnodarone, ajmaline, verapamil, procainamide, quinidine, thiopental or sodium hexenal, monoamine oxidase inhibitors, cimetidine, polymyxin-B, sedatives or hypnotics

Buy Dona injection solution 200mg/ml 2ml No. 6 in pharmacies

Trade name of the drug:

DONA®

International nonproprietary name:

glucosamine

Dosage form:

solution for intramuscular administration.

Compound:

Solution A: each ampoule (2 ml) contains:

active substance: crystalline glucosamine sulfate 502.5 mg (contains 400 mg glucosamine sulfate and 102.5 mg sodium chloride);

excipients: lidocaine hydrochloride 10.0 mg, water for injection up to 2 ml.

Solution B: ampoule volume (1 ml) contains:

excipients: diethanolamine - 24.0 mg, water for injection up to 1 ml.

Description:

solution A is a transparent liquid from colorless to light brown, without suspended particles; solution B – colorless transparent liquid without suspended particles; solution A plus solution B is a clear liquid from colorless to light brown, without suspended particles.

Pharmacotherapeutic group:

tissue repair stimulator.

Pharmacological properties

Dona - has an anti-inflammatory and analgesic effect, replenishes endogenous glucosamine deficiency, stimulates the synthesis of proteoglycans and hyaluronic acid in synovial fluid; increases the permeability of the joint capsule, restores enzymatic processes in the cells of the synovial membrane and articular cartilage. Promotes fixation of sulfur during the synthesis of chondroitinsulfuric acid, facilitates normal calcium deposition in bone tissue, inhibits the development of degenerative processes in joints, restores their function, reducing joint pain.

Pharmacokinetics

When administered intramuscularly, bioavailability is 95%, rapidly distributed in tissues, half-life of about 60 hours, excreted mainly by the kidneys.

Indications for use

Primary and secondary osteoarthritis, osteochondrosis, spondyloarthrosis.

Contraindications

Individual hypersensitivity to glucosamine, lidocaine hydrochloride and other components of the drug. Due to the presence of lidocaine in the product, it is contraindicated in patients with cardiac conduction disorders and acute heart failure, a history of epileptiform seizures, severe liver and kidney dysfunction; during pregnancy and lactation, as well as in children under 12 years of age.

Carefully

The drug should be used with caution in patients with chronic heart failure and arterial hypotension. Caution should be exercised in patients with allergies to seafood (shrimp, shellfish).

Directions for use and doses

Intramuscularly! The drug is not intended for intravenous administration.

Before use, mix solution B (solvent) with solution A (drug solution) in one syringe. The prepared solution of the drug is administered intramuscularly in a dose of 3 ml (solutions A + B) 3 times a week for 4-6 weeks. Injections of the drug can be combined with oral administration of the drug in powder to prepare an oral solution (sachets). The duration and regimen of treatment is prescribed by the attending physician.

Side effect

The drug is well tolerated. In some cases, possible: flatulence, diarrhea, constipation, allergic reactions - urticaria, itching. Due to the content of lidocaine in the drug, the following are possible: nausea, vomiting, drowsiness, diplopia, headache, dizziness, numbness of the tongue and oral mucosa, tremor, euphoria, disorientation, cardiac conduction disturbances.

Overdose

No cases of overdose have been reported.

Interaction with other drugs

Compatible with non-steroidal anti-inflammatory drugs, paracetamol and glucocorticosteroids.

Caution should be exercised when prescribing injections of the drug in combination with beta-blockers, digitoxin, ajmaline, amiodarone, verapamil, quinidine, procainamide, hexenal or sodium thiopental, MAO inhibitors, polymyxin-B, hypnotics or sedatives, cimetidine.

special instructions

When using the drug in patients with impaired glucose tolerance, with severe liver and kidney failure, medical supervision is necessary.

Release form

Solution for intramuscular administration 200 mg/ml. 2 ml in ampoules A of transparent light-protective glass, type 1, ampoules have a white ring indicating the place where the ampoules are broken.

Solvent. 1 ml in ampoules B of transparent colorless glass, type 1, ampoules have a white ring indicating the place where the ampoules break.

6 ampoules A in a PVC tablet and 6 ampoules B (solvent) in a PVC tablet are placed together with instructions for use in a cardboard box.

Best before date:

2 years.

Do not use the drug after the expiration date indicated on the package.

Storage conditions

At a temperature not exceeding 25° C. Store out of the reach of children.

Conditions for dispensing from pharmacies

On prescription.

Analogs

Don's injection solution has a fairly high price, which often leads to the need to choose a more affordable analogue. Drugs with similar effects include:

• Sustagard Arthro - heals and restores damage to joint tissues. Glucosamine also acts as an active component. The mechanism of action is almost completely identical to Dona, but costs a little less;
• Artradol - similar to the drug described, but the active substance is different - sodium chondroitin sulfate, also injected into the muscle;
• Elbona - will replace Dona if the patient has allergic manifestations. Glucosamine is also an active ingredient, but its concentration is significantly lower than in the product described;
• Chondroxide is a gel for external use. This remedy is quite weak and is more suitable for the prevention of joint problems than for their treatment.

There is another effective analogue in tablet form. This is Aminoarthrin, the active ingredient in it is glucosamine hydrochloride.

Experts advise paying close attention to the condition of your joints. Some patients sometimes ignore the pain that haunts them, citing the fact that the back or knees are not such important organs as, for example, the head or heart. However, such negligence towards one’s own body is unacceptable. Don's drug has proven itself on the positive side. Many reviews from satisfied patients indicate its safety and effectiveness.

It is better to pay attention to your health today, consult a doctor if you have any discomfort in the joints. The specialist will select adequate treatment and prescribe Don in tablets or injections

Analogs

The group of chondroprotective drugs used for intramuscular administration includes Alflutop, Adgelon, Elbona, Chondrolone, Noltrex.

It is worth noting that chondroprotectors can be used as substitutes for intra-articular fluid in case of its shortage. They not only protect cartilage from damage and destruction, but also replace synovium. Such drugs include products that contain Hyaluronic acid - Sinvisc, Ostenil, Sinokorm, Fermathron.

The use of intra-articular injections with Hyaluronic acid practically does not cause complications or side effects, since hyaluron is a natural component for the body.

They are injected directly into the articular cavity of large joints and are most often prescribed for deforming arthrosis of the knee joint. The therapeutic course consists of no more than 5 injections, but often one is enough. If necessary, the course is repeated no earlier than after 6 months.

Intra-articular injections are performed strictly in a hospital setting, since they are a surgical procedure. Injections into the hip joints (HJ) are done only in exceptional cases due to their deep location: it is extremely difficult to insert a needle into the HJ “blindly”, so the procedure is carried out under X-ray control.

Special instructions and precautions

Glucosamine is not used to relieve acute pain. Elimination of pain symptoms occurs several weeks after the start of therapy, sometimes a longer period is needed. If a patient has been given Don injections for two or three months, and there is still no improvement, the treatment regimen should be adjusted. You may need to choose a different medication.

If the patient has received glucosamine, the course of treatment has already been completed, but the pain is only getting worse, you should consult a doctor.

Special monitoring and caution are required for patients with problems such as:

• renal, liver failure;
• bronchial asthma;
• diabetes.

Use during pregnancy and lactation

There are no clinical studies of the drug’s effect on fetal formation and its penetration into breast milk. In this regard, doctors prohibit giving Don injections to pregnant and lactating women.

Drug interactions

When taken together, Dona enhances the effect of drugs such as:

• glucocorticosteroids;
• monoamine oxidase inhibitors;
• sleeping pills and sedatives;
• adrenergic blockers;
• coumarin anticoagulants.

A weakening of the effect when used simultaneously with Dona is observed in:

• chloramphenicol;
• semisynthetic penicillins.

You cannot decide on a combination of medications on your own. Specialist consultation is required.