Comparative analysis of the use of Dimexide gel and Dimexide solution in patients with vertebrogenic dorsalgia

Composition of Dimexide

The concentrate for preparing Dimexide solution contains at least 99% dimethyl sulfoxide (DMSO) undiluted.
Dimexide gel contains DMSO at a concentration of 0.25 mg/g or 0.5 mg/g, as well as nipagin, nipazole, sodium carmellose, and purified water.

Dimexide ointment is prepared on the basis of polyethylene oxide 1500 gel (an emulsifier is added to it to give the preparation the necessary consistency) or on the basis of mink oil. The concentration of the active substance is from 30 to 70%.

DMSO is also included in some gels and ointments ( Triacort , Dolobene , Chondroxide , Capsicam , Remisid , Ketorol) , but in them it acts as a penetrator and is not an active substance.

Contains DMSO and Propolis-D . In addition to this substance, the medicine contains propolis extract 20% and cocoa butter.

Pharmacodynamics and pharmacokinetics

Dimexide - what is it?

To the question “What is Dimexide?” Wikipedia answers that this is an external drug that is used primarily to relieve pain and inflammation in diseases of the musculoskeletal system (MSD), as well as to enhance the penetration of a number of other drugs into tissues.

Pharmacodynamics

The mechanism of action of DMSO is associated with the ability of this substance to inactivate hydroxyl radicals and improve the course of metabolic processes in the site of inflammation.

The drug has a local analgesic and anesthetic effect . Shows moderate fibrinolytic and antiseptic activity.

DMSO helps normalize the processes of fibrin formation, improves microcirculation in tissues, inhibits erythrocyte and neutrophil , increases the activity and intensity of phagocytosis , and reduces the content of CEC.

When applied topically, it quickly and well passes through biological membranes (mucous membranes, skin, bacterial cell walls), increasing their permeability to other drugs.

These properties of DMSO allow it to be used as a transporter of other drugs through mucous membranes and skin.

Pharmakinetics

When applied to mucous membranes or skin, it is absorbed quickly and almost completely.

Bioavailability - 60-70%. Moreover, the penetration depth and bioavailability of DMSO are directly proportional to its concentration.

After application to the skin, the drug is detected in the blood serum within ten minutes. Concentrations reach peak values ​​after four to eight hours.

Penetrates well into tissue cells of all organs. The exception is cells of nails, hair, and tooth enamel.

In the body, DMSO is oxidized to methylsulfonylmethane and then reduced to dimethyl sulfide.

The active substance and its metabolic products are excreted in feces and urine. In addition, DMSO can be excreted through the lungs and skin, which is accompanied by the appearance of a specific garlic odor.

Even with long-term use of Dimexide, DMSO and its metabolites do not accumulate in the body.

Dimexide

Dimexide (active ingredient - dimethyl sulfoxide) is an anti-inflammatory and analgesic drug for external use, used mainly for the complex treatment of diseases of the musculoskeletal system. It has a moderate disinfecting and fibrinolytic effect. Dimethyl sulfoxide, the active component of the drug, suppresses inflammatory tissue infiltration. In addition, it normalizes the process of fibrin formation, stimulates blood circulation in the capillary bed, suppresses aggregation (sticking together) of red blood cells, activates phagocytosis, inhibits neutrophil chemotaxis, and reduces the concentration of immune complexes circulating in the plasma. Dimexide penetrates well through the skin, mucous membranes and even the cell walls of microorganisms, as well as other biological membranes, making them more permeable, including for other drugs. In addition, the drug increases the sensitivity of bacteria to antibiotics. Among the advantages of dimexide, one should also note its low toxicity. When the drug is applied externally, the active substance is detected in the blood within 10-15 minutes, with the maximum concentration achieved after 2-8 hours. After 30-36 hours, dimethyl sulfoxide is no longer detectable in the blood. When used topically, dimexide also penetrates into the joint cavity. Once in the blood, the drug binds to plasma proteins. Dimexide does not accumulate in the body. The drug is excreted unchanged or in the form of metabolites (dimethyl sulfone, dimethyl sulfate) by the kidneys along with urine. A small part of dimexide in the form of a reduction product (dimethyl sulfide) is released along with exhaled air.

Dimexide is available in a single dosage form - as a gel for external use. For adults and children over 12 years of age, apply a thin layer of gel to the affected area 1-2 times a day. The duration of treatment is on average 1.5-2 weeks. A repeated course of medication may be administered no earlier than after 10 days.

Considering the possible development of reactions of individual intolerance to dimexide, it is recommended to conduct a drug test to determine compatibility with it before starting treatment. To carry it out, the gel is applied to the skin in the elbow area. If after this there is severe hyperemia and itching, the drug should not be used. If allergic reactions develop during the course of medication, treatment is stopped and antihistamines are prescribed. An overdose of dimexide is manifested by an increase in dose-dependent negative side effects. In such cases, treatment should be interrupted, rinse the damaged area with water, completely removing the drug from the surface of the skin. When used together, dimexide does not exhibit pharmacological antagonism towards heparin, local antibiotics and non-steroidal anti-inflammatory drugs. The drug increases the sensitivity of bacteria to aminoglycosides and beta-lactams, chloramphenicol, griseofulvin, rifampicin. As already noted, dimexide dramatically increases the ability of drugs to penetrate the skin and create peak concentrations at the site of their application. The presence of its own antibacterial effect, the ability to activate nonspecific

Resistance factors stimulate skin restoration in various destructive processes. This makes it possible to effectively use dimexide to treat patients with erysipelas. In clinical studies, the drug significantly reduced the duration of external symptoms of inflammation - hyperemia, swelling, pain. Purulent complications when dimexide is included in a complex drug course of treatment for patients with erysipelas are not

registered. In the group in which this drug was not used, the number of purulent complications was close to 10%. Side effects when using dimexide are quite rare and in most cases are of no clinical significance and are not grounds for discontinuation of the drug.

Indications for use of Dimexide

Dimexide has been approved for medical use since 1971. Indications for use of the medicine:

• sprains;
• edema of various etiologies;
• purulent wounds;
• phlegmon;
• trophic ulcers;
• lymphostasis;
• burns;
• hemorrhages in the joints;
• thrombophlebitis (acute or chronic);
• eczema;
• erysipelas;
• diffuse streptoderma;
• keloid scars;
• discoid lupus erythematosus;
• limited scleroderma ;
• alopecia;
• pyoderma;
• erythema nodosum;
• furunculosis;
• acne.

According to the manufacturer's instructions, applications with Dimexide are prescribed for diseases of the musculoskeletal system such as deforming osteoarthritis (in case of damage to periarticular tissues), ankylosing spondylitis , rheumatoid arthritis , reactive synovitis , radiculitis . The drug is used in combination with other drugs and procedures.

Dimexide is effective for bruises and gout ; it is used to accelerate the resorption of traumatic infiltrates and to treat heel spurs.

For a number of neurological diseases, as well as when it is impossible to use oral forms of NSAIDs (for example, with peptic ulcer electrophoresis with Dimexide may be recommended This method of treatment is used when it is necessary to relieve joint pain, pain due to osteochondrosis or post-traumatic pain (including if the patient has a damaged nerve).

In skin plastic surgery, Dimexide is used for the preservation of skin homografts , as well as for the treatment of transplanted skin homo- and autografts .

In dental practice, the product is used for inflammatory processes in the maxillofacial area and inflammatory damage to the salivary glands , for pulpitis , periodontitis , periodontitis , arthritis/atrosis of the temporomandibular joint .

Indications for use in gynecology are colpitis , cervical erosion , endometritis , adnexitis , thrush , complications developing after gynecological operations and childbirth, etc.

Due to its bactericidal and anti-inflammatory properties, the drug is often used in cosmetology. A mask with Dimexide and Solcoseryl is considered one of the most effective remedies for wrinkles and the best replacement for mesotherapy and Botox , and compresses and wraps with the solution help reduce the appearance of cellulite . In addition, cosmetologists recommend the drug as an anti- acne .

Hair masks with natural oils and Dimexide reduce hair loss and stimulate hair growth.

COMPARISON OF THE EFFECTIVENESS OF DIMEXIDE GEL AND PLACEBO IN THE TREATMENT OF PATIENTS WITH VERTEBROGENIC DORSALGIA

Relevance. According to the results of a report by the World Health Organization (WHO) in Geneva (2003), pain in the spine “has reached epidemic proportions” [11, pp. 50-55]. The frequency of pain in the spine leading to disruption of daily activities and forcing people to seek medical help reaches 80% worldwide [1, pp. 6-10, 5, pp. 51-55]. In Russia, the frequency of dorsopathies is 71-80% among all diseases of the peripheral nervous system [6, P. 24].

Currently, the prevalence rates of vertebroneurological pathology tend to increase [3, pp. 11-16.]

With timely treatment, the pain syndrome is relieved within 1-2 weeks, and in 20%, chronic disease is observed [7, pp. 590-593]. In addition, the peak incidence occurs at working age 30-55 years. [5, p. 86]. This determines the economic importance of vertebrogenic diseases, which is associated with increasing direct costs of treating patients, as well as indirect costs due to temporary disability [12, P. 496-500].

The main goals of treatment are relief of pain, neurological symptoms, and prevention of chronicity of the disease. Priority is given to conservative therapy.

The effectiveness of NSAIDs in relieving pain has been repeatedly confirmed in randomized controlled trials [2, pp. 11-16, 5. pp. 51-55]. This is due to their pronounced anti-inflammatory and analgesic effect. However, there is a wide range of adverse events associated with NSAID treatment.

Every year, NSAID-induced gastropathy leads to 100-200 thousand hospitalizations and 10-20 thousand deaths [8, pp. 47-50]. Much attention is paid to cardiovascular adverse events of NSAIDs, in particular myocardial infarction and cerebrovascular accidents [10, pp. 71-78]. Prevention, and especially treatment of class-specific complications, represents one of the most important iatrogenic problems in medicine.

Therefore, before starting therapy, it is necessary to weigh the ratio of the expected benefit and the possible danger of complications in each specific case, especially if back pain is not accompanied by other symptoms that could indicate a disease of the spine or involvement of the structures of the nervous system in the process. All of the above creates the prerequisites for finding new ways to effectively treat vertebrogenic pain. One of the possibilities to solve this problem is the use of local means.

A fundamentally important feature of their use is their predominantly local effect, despite the fact that only a small amount of the drug can enter the bloodstream. Accordingly, the systemic effects of their use, including negative ones, turn out to be minimal [9, pp. 85-89].

Purpose of the study: comparative assessment of the effectiveness of a local drug (dimexide gel) with placebo in patients with vertebrogenic dorsalgia.

Study design. On the basis of the neurological department of the MRCH, a clinical study was conducted on 68 patients aged 18 to 77 years with acute, subacute and chronic (in the acute stage) course of vertebrogenic dorsalgia, including those caused by herniated intervertebral discs, which do not require surgical treatment, confirmed by neuroimaging. Also, inclusion criteria were moderate or severe pain syndrome (score on a visual analogue scale of more than 3 points); absence of clinically significant dysfunction of the liver and gastrointestinal tract, as well as the patient’s consent to participate in the study.

Patients with tumor and infectious-inflammatory vertebrogenic diseases, concomitant neurological pathology, gastric or duodenal ulcers in the acute stage, with mental and unstable somatic diseases, as well as those who had absolute indications for surgical intervention or consequences of surgical intervention were excluded from the study. interventions on the spine.

The patients were randomly divided into 2 groups. 38 people of the first group received dimexide gel 25%, the second group of patients, 30 people, used placebo. Patients applied the drugs to the skin in the painful area 2 times a day, lightly rubbing.

Local drugs were prescribed in complex therapy (muscle relaxants, vascular therapy, B vitamins, antidepressants, massage, exercise therapy, IRT).

The total duration of treatment was 10 days. Patients were examined initially (before the start of treatment) and at the end of the course of therapy. A visual analogue scale (VAS) was used to determine the patient’s subjective sensation of pain at the time of the study and to determine the dynamics of pain intensity under the influence of therapy. To assess the severity of muscle syndrome, the muscle syndrome index (MSI) was calculated. The degree of impairment of quality of life was assessed using the Roland-Morris questionnaire. The severity of movement limitation in the affected part of the spine was also determined in degrees.

Results and discussion . In all respondents, the duration of the disease was at least 1 year, and the duration of pain before treatment was 18.4±5.3 days. The neurological status of all patients before the start of therapy was determined by pain on palpation of the spinous processes, paravertebral points of the affected part of the spine and muscle tension.

The intensity of pain according to VAS before treatment in the studied groups did not differ significantly and was 7.46 ± 0.76 points (group 1, receiving dimexide gel), 7.13 ± 1.02 points (group 2, receiving placebo). After treatment, the pain intensity in the first group was 2.58±0.59 points according to VAS, and was significantly less than in patients of group 2 - 4.73±1.13 points (p<0.05).

To study quality of life (QOL), the Roland-Morris Low Back Pain and Disability Questionnaire was used. The questionnaire contains 18 statements describing limitations due to back pain. Patients noted those that corresponded to their condition at the time of filling out the questionnaire. Then the total number of points noted by the patient was calculated (maximum - 18). Disturbances in vital functions were considered severe if the patient noted more than 7 points. QoL changes depending on the patient’s condition, which allows monitoring the treatment.

A study of quality of life before treatment showed that patients had significant limitations in daily functioning. The indicators of patients in the two groups did not differ significantly from each other. In the first group, those treated with dimexide gel, the average value of disability was 10.31 ± 1.05, and in the group receiving placebo it was 10.4 ± 1.03. After treatment, a significant improvement in quality of life was noted in the first group of patients. Thus, the average score of the questionnaire after treatment was 4.05±0.49, which indicates an improvement in the quality of life of patients in the first group by 60% compared to the initial level. In patients of group 2, when analyzing QOL, a less pronounced effect was noted - the overall indicator was 6.73 ± 1.12. , and the improvement was only 35% of the original. Thus, the results obtained once again prove the effectiveness of dimexide gel in comparison with placebo.

The data on IMI in the groups before the study corresponded to the following values: in the first 9.28±0.72 points and in the second 9.69±1.07 points. There were no significant differences between the groups.

After therapy with dimexide gel, a mild degree of UTI was observed in 29 people (76.3%), in patients receiving placebo, a mild degree of severity was detected in 10 people (33.3%). Only one patient from the first group (2.63%) had severe IMS after treatment, and when using placebo, there was no positive effect on muscle syndrome in 4 people (13.3%). The results obtained indicate the advantage of dimexide gel in relief of muscle syndrome before placebo.

Before treatment, all examined patients were found to have limited movement of the affected part of the spine due to pain. During treatment with dimexide gel, mobility limitation significantly (p<0.05) disappeared in 15 patients (39%), and no patients with identified mobility limitation were identified. After treatment in the second group of patients, the restriction disappeared only in 8 patients (27%) and in 6 people (20%) a pronounced limitation of mobility remained. It can be concluded that dimexide gel is effective in increasing the mobility of the affected part of the spine and, consequently, in improving the quality of life of patients.

Conclusion. Due to its high prevalence and significant treatment costs, back pain is not only a socially but also an economically significant problem. Due to the increase in patients with this pathology, the development of new methods of therapy remains relevant, which would increase the effectiveness of treatment with a minimum number of unwanted and dangerous effects. The use of local dosage forms may be a solution to this problem in a number of patients.

In our study, dimexide gel showed a good analgesic and anti-inflammatory effect. This drug reduced pain and muscle syndrome, improved the functional state of the spine, which was accompanied by an improved quality of life. This allows us to recommend it as an effective remedy for relieving vertebrogenic pain syndrome.

Bibliography:

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2. Alekseeva L. I. Issues of using non-steroidal anti-inflammatory drugs in rheumatological practice. // Consilium-Medicum. 2009. No. 11. pp. 43-47.
3. Vorobyova O. V. Radicular pain: clinical picture, diagnosis, principles of treatment // Doctor: monthly scientific, practical and journalistic journal. 2011. N 5. P. 11-16.
4. Kamchatnov P.R., Salnikova G.S. Pain in the lower back: increasing the effectiveness of treatment // Handbook of a polyclinic doctor. - 2011. - N3. — P. 51-55.
5. Kiryanova V.V., Egorova G.I. et al. Combined use of ultrasound and Artrosilene gel for diseases of the spine // Nelek. Med. - 2007. No. 4. P. 86.
6. Kochuneva O. Ya. Underwater vertical traction of the spine in complex restorative treatment of patients with dorsopathy of the lumbosacral level: abstract. dis. Ph.D. honey. sciences.// M.: 2004. P. 24.
7. Parfenov V. A. Muscle spasm during back pain, pathogenesis, diagnosis and treatment // Breast cancer. 2003. T. 11. No. 10. pp. 590-593.
8. Sturov N.V., Cheltsov V.V. Safety of use // Difficult patient -2005. No. 6. Volume 3. pp. 47-50.
9. Umarova Kh. Ya., Kamchatov P. R. Use of transdermal dosage forms of non-steroidal anti-inflammatory drugs in patients with lumbar pain // Consilium Medicum. 2014. No. 9. pp. 85-89.
10. Ushkalova E. A. Cardiotoxicity is a group property of coxibs // Pharmateka. 2005. No. 7. P. 71 – 78.
11. Chichasova, N.V. “New approaches to the relief of acute pain syndrome in rheumatology and neurology” // Consillum medicum. No. 2. pp. 50-55.
12. Lampert BA Interventional treatment of low back pain // Mo. Med. 2007. Vol. 104(6). P. 496-500.

Contraindications

Contraindications for use:

• intolerance to the components of the drug;
• liver/kidney failure;
• stroke;
• severe atherosclerosis ;
• angina pectoris;
• myocardial infarction;
• cataract;
• glaucoma;
• coma;
• pregnancy;
• lactation.

When prescribing a drug, take into account the fact that it can enhance not only the activity, but also the severity of the toxic effects of a number of drugs.

When even a small amount of dimethyl sulfoxide is swallowed, as well as when used for applications in the oral cavity, the patient may experience stomach upset or intestinal spasms.

Dimexide gel for external use 25%, 30 g

Manufacturer

Pharmamed LLC, Russia

Compound

Active ingredient:
dimexide (dimethyl sulfoxide) 25 g;

Excipients:

methyl parahydroxybenzoate (nipagin) - 0.05 g;

propyl parahydroxybenzoate (nipazole) - 0.013 g;

carmellose sodium (sodium carboxymethylcellulose) - 2 g;

purified water - up to 100 g

pharmachologic effect

Dimexide is an anti-inflammatory agent with local analgesic and anti-inflammatory effects. Has a moderate antiseptic and fibrinolytic effect.

Dimethyl sulfoxide inhibits inflammatory tissue infiltration. In addition, dimethyl sulfoxide helps normalize the processes of fibrin formation, increases microcirculation in tissues, inhibiting erythrocyte aggregation, increases the activity of phagocytes, suppresses neutrophil chemotaxis and reduces the content of circulating immune complexes.

Penetrates through the skin, mucous membranes, bacterial cell walls (increases their sensitivity to antibiotics) and other biological membranes, increasing their permeability to drugs. The drug is low toxic.

Pharmacokinetics

When the drug is applied, dimethyl sulfoxide is detected in the blood serum after 8–15 minutes, with the maximum content observed after 2–8 hours. As a rule, after 30–36 hours, dimethyl sulfoxide is no longer detected in the blood serum. Dimethyl sulfoxide does not accumulate. When applied topically, dimethyl sulfoxide penetrates the joint cavity and binds to proteins in the blood and tissues.

Excreted from the body through the kidneys unchanged and in the form of oxidation products - dimethyl sulfone and dimethyl sulfate; and also in the form of a reduced product (dimethyl sulfide) is released in exhaled air.

Indications

Used to relieve pain in the complex treatment of rheumatoid arthritis, ankylosing spondylitis, deforming osteoarthritis, arthropathy, radiculitis, trigeminal neuralgia, etc., for the treatment of bruises, ligament damage, traumatic infiltrates in the treatment of erythema nodosum.

Contraindications

• hypersensitivity to Dimexide or other components of the drug;
• severe damage to the liver and kidneys;
• angina pectoris;
• myocardial infarction;
• severe atherosclerosis;
• various types of stroke;
• glaucoma, cataract;
• coma;
• pregnancy;
• lactation period;
• children's age up to 12 years.

With caution: due to the fact that Dimexide can enhance not only the activity, but also the toxicity of some drugs, caution should be exercised when prescribing it simultaneously with other drugs.

Side effects

During the use of the drug, contact dermatitis, a garlicky odor of exhaled air, increased skin pigmentation, allergic reactions, erythematous rashes, dry skin, and a slight burning sensation may be observed.

Some patients do not perceive the smell of the drug well (nausea, vomiting); in isolated cases, bronchospasm is possible.

If any of the side effects indicated in the instructions worsen or any other side effects not specified in the instructions appear, you must inform your doctor.

Interaction

Enhances the penetration of drugs (NSAIDs, antibiotics, etc.) through the skin, which leads to an increase in their activity, and in some combinations - to toxicity.

How to take, course of administration and dosage

Externally.

For adults and children over 12 years of age, the drug is applied in a thin layer to the affected area 1-2 times a day.

Duration of treatment is 10–14 days.

Repeated courses can be carried out no less than 10 days later.

Overdose

Symptoms: increased dose-dependent side effects.

Treatment: in these cases, the drug should be discontinued, the damaged area should be washed, and the drug should be removed.

Special instructions

Considering the possibility of individual intolerance to the drug, it is recommended to conduct a drug test to determine tolerance to it.

To do this, apply a thin layer of gel to the skin of the elbow.

The appearance of severe redness and itching indicates increased sensitivity to Dimexide.

If allergic reactions occur during treatment with the drug, the use of the drug is stopped and H1-histamine receptor blockers are prescribed.

Release form

gel for external use

Storage conditions

At a temperature not exceeding 25 °C.

Best before date

2 years

Active substance

Dimethyl sulfoxide

Dosage form

gel for external use

Purpose

For children over 12 years old, For adults

Indications

Rheumatoid arthritis, Osteoarthritis, Arthrosis, Arthritis, Bruises, Hematomas

Barcode and weight

Barcode: 4607068360334, 460358600137, 4603586001377, 4607068360891 Weight: 0.048 kg

Instructions for use of Dimexide (Method and dosage)

Dimexide solution: instructions for use

A solution based on Dimexide concentrate (Dimexide Zhff, Dimexide Lugal) is used as a means of external therapy. It is used for washing affected body surfaces (irrigations) and in the form of applications.

Moisten a gauze pad in a solution of the required concentration and apply it to the affected area for 20-30 minutes. The top of the napkin is covered with plastic film and linen (or cotton) cloth. It is recommended to repeat the procedures 1-3 times/day (depending on the indications) for 10-15 days.

How to dilute Dimexide concentrate depends on the purpose for which the medicine is being prepared.

To treat trophic ulcers, a 30-50% solution of dimethyl sulfoxide is used (for one treatment, 50 to 100 ml of liquid is used), eczema - a solution with a concentration of 40-90%.

For local anesthesia, the drug is used 2 or 3 times a day in the form of compresses with a 25-50% solution. Single dose - from 100 to 150 ml.

For joint pain (for example, with atrosis of the knee joint), lotions on the joint with the drug diluted to the same concentration are indicated. Compresses with Dimexide for the knee or ankle are applied for 20-60 minutes. The course is designed for 15-20 procedures.

If the lesion is localized in a highly sensitive area of ​​the body, the concentrate is diluted to obtain a 10-30% solution.

For patients who have undergone skin plastic surgery, bandages impregnated with a 10-20% Dimexide solution are applied to the transplanted homo- and autografts immediately after the operation and subsequently until the transplant is permanently engrafted.

To preserve skin homografts, a 5% solution of DMSO in Ringer's solution is used.

Less concentrated solutions are used for washing inflammatory and purulent-necrotic lesions and cavities.

Gel Dimexide: instructions for use

The gel (ointment) is used as a means of external therapy to treat patients over 12 years of age.

The product is applied to the affected area of ​​the body in a thin layer from 1 to 3 rubles/day. Gel 50% is intended for treating the skin; for mucous membranes it is recommended to use gel 25%. The course lasts from 10 to 15 days. It can be repeated no earlier than 10 days later.

For diffuse streptoderma , eczema , as well as for local anesthesia, applications with gel (50%) in the form of compresses are used. The procedure is repeated 2-3 times during the day.

For thrombophlebitis, the patient is prescribed simultaneous applications of Dimexide with heparin gel or heparin ointment . Applications should be done 2-3 rubles/day. The course is designed for 10-15 procedures.

In skin plastic surgery, dressings with 25% gel are applied to skin homo- and autografts . The first bandage is applied immediately after the operation, and further procedures should be repeated until the implant is firmly engrafted.

How to dilute the drug for joints for gout?

For diseases of the rheumatic type (in particular, gout ), compresses with Dimexide can significantly reduce pain and quickly relieve inflammation in them.

Penetrating well into the tissue, the drug promotes the gradual dissolution of salt build-ups on the joints of the small bones of the foot and joints affected by the pathological process.

To prepare a compress, the concentrate is diluted in an equal volume of water at room temperature. Then a piece of gauze is folded into several layers, soaked in the resulting solution, applied to the sore spot and insulated with polyethylene, cotton cloth and a woolen scarf.

Exposure time is from 20 minutes to half an hour. Treatment, depending on the degree of joint damage, lasts from 10 days to 2 months.

Since Dimexide is a good transporter of other drugs, before using it, to enhance the effect, you can lubricate the sore joint with anti-inflammatory ointment/gel ( Bystrum-gel , Chondroxide and their analogues).

To relieve intense pain, Dimexide (30 ml) can be mixed with a two percent solution of Novocaine (50 ml). The bandage is applied in the same sequence. Exposure time is from 30 minutes to 1 hour.

How to dilute Dimexide for a compress for heel spurs?

With a heel spur, to alleviate the patient’s condition and improve his quality of life, Dimexide is used in small dosages in the form of compresses or rinses.

To prepare the solution, the concentrate is diluted with water in a ratio of 1:5. Then a napkin soaked in liquid is placed on the sore heel and a sock is put on top. Exposure time: 30 minutes.

The effect of the procedure will be more pronounced if you rub anti-inflammatory ointment into the sore spot 15 minutes before applying the compress.

of Hydrocortisone , Dropiredol , Novocaine , Analgin to the Dimexide solution . This composition gives the best anti-inflammatory and analgesic effect. The compress should be removed no later than after 40 minutes, otherwise skin irritation may occur.

Why is Dimexide used in pediatrics?

In children, Dimexide is used to treat diseases of the musculoskeletal system , inflammatory , purulent and ulcerative skin lesions , erysipelas , eczema , streptoderma , burns , as well as diseases of the upper respiratory tract .

Compresses with the drug warm up well, stop the inflammatory process and relieve coughs that irritate the throat. This treatment is appropriate for pharyngitis , tonsillitis , and sore throat .

The proportions of the Dimexide compress with Novocaine for cough are as follows: three to four parts of water to one part of the concentrate (the younger the child, the less concentrated the solution should be prepared).

To prepare the composition, you can use two parts of the concentrate: one part water, one part juice squeezed from aloe stems and two parts honey melted in a water bath. Before use, the mixture is slightly warmed.

Gauze folded five times and soaked in the resulting mixture is applied to the throat and secured first with polyethylene and cotton cloth, and then with a scarf. Remove the compress after 50 minutes (earlier if a burning sensation occurs).

It is better to carry out the procedure at night.

For bronchitis , compresses with Dimexide help relax the bronchi and improve blood circulation.

The instructions for a compress with Dimexide and Novocaine for a child are as follows: one tbsp. a spoonful of concentrate is diluted in the same volume of boiled/distilled water, then diclofenac sodium (one ampoule) and 10 ml of a two percent solution of Novocaine .

Gauze soaked in the product is applied to the feet, back (in the area of ​​the shoulder blades) and chest, covered with polyethylene and secured with a bandage (scarf). The child is covered with a blanket. The duration of the procedure is 30 minutes. Compresses are applied once a day for a week and only if the child has a normal temperature.

The medicine is used warm (but not hot!). When applying gauze to the chest, avoid the heart area.

Contraindications for use in pediatrics are pathologies of the heart, blood vessels, kidneys and liver, problems with the immune system, age under 12 years, elevated body temperature.

Application in gynecology: how to make tampons with Dimexide?

Dimexide is used in gynecology in the form of vaginal tampons. To prepare a medicinal mixture, one part of the concentrate is diluted in five parts of water, and then aloe juice, antibiotics or Lidase .

Ready-made tampons that women use for menstrual bleeding are not suitable for treatment, since they are often impregnated with various compounds that can react with dimethyl sulfoxide. Therefore, tampons should be made independently from sterile cotton wool.

The tampon should be inserted into the vagina in such a way that it can be easily removed. The active substance is quickly absorbed, penetrating the inflamed ovaries or uterus even with shallow injection.

The duration of each procedure, as well as the duration of the course, depend on the degree of neglect of the pathological process.

Propolis-D as an adjuvant .

Due to the presence of propolis and DMSO in these suppositories, they provide good pain relief, stop the inflammatory process, have an antibacterial effect, help strengthen the immune system and increase the effectiveness of basic therapy.

They should be used twice a day, one at a time, for 10-14 days.

Dimexide for hair

The use of Dimexide in combination with natural oils and vitamins helps improve the structure and accelerate hair growth. What is dimethyl sulfoxide? A conductor for other substances and a universal stimulator of metabolic processes.

Mask with Dimexide for oily hair: one part of Dimexide concentrate, one part of ampoule solutions of vitamins A and E, one part of lemon juice (the juice can be replaced with vodka, cognac or 70-degree alcohol if desired). This composition should be left on the hair for no more than half an hour.

A mask for oily hair based on Dimexide (1 teaspoon), macadamia oil (1 teaspoon), almond oil (1 teaspoon), eggs (1 piece), cognac (1 tablespoon) also earned good reviews from trichologists. ). The mixture is applied to the hair for half an hour, then washed off with shampoo and rinsed with water and lemon juice.

To prepare a mask for hair growth and strengthening hair follicles, you need to mix castor and burdock oils taken in equal volumes, add to them oil solutions of vitamins E and A (one ampoule each) and 5 drops of lemon juice. Mix the ingredients thoroughly and add 1 tbsp. a spoonful of Dimexide concentrate.

After the composition is applied to the hair roots, a plastic cap is put on the head and tied with a towel. After an hour (if a burning sensation occurs - immediately), the hair is washed with shampoo.

A similar composition in which lemon juice is replaced with the yolk of one egg also works well on hair.

To stimulate hair growth, use a mask with sea buckthorn oil. To prepare the composition, mix the heated oil with the concentrate in a 3:1 ratio. The mixture is rubbed into the hair roots, insulated with polyethylene and a towel, and washed off after an hour. Instead of a rinse aid, at the end of the procedure you can use apple cider vinegar diluted with water in a ratio of 1:10.

Reviews about Dimexide for hair growth are mostly positive, but it should be remembered that the drug is a powerful pharmaceutical that has a number of contraindications and can cause a fairly severe burn.

Dimexide for face

In facial cosmetology, Dimexide is used to improve the condition of aging skin, as well as to treat problematic skin prone to rashes.

A very effective remedy for combating wrinkles and rejuvenating the face is a mask made from Dimexide and Solcoseryl . To begin with, you should dilute one volume of concentrate in ten volumes of boiled water and thoroughly wipe your facial skin with this solution. Then Solcoseryl .

The duration of the procedure is one hour. During this entire time, the mask must be sprayed with warm water so that it does not harden. After an hour, the gel (or ointment) is removed with a damp cotton swab, and the skin is moisturized with cream.

To prevent wrinkles, the mask can be done 1-2 times a month, if there are deep wrinkles - once every three days for a month.

An equally popular care product is a face mask with Dimexide and melaleuca (tea tree) oil. This composition is good at treating purulent-inflammatory skin lesions.

To prepare the mask, you need to mix equal volumes of a 10% aqueous solution of Dimexide and essential oil. The product is applied to the face using a cotton sponge for several hours or overnight, and then the residue is washed off with warm water. If a burning sensation occurs, wash off the mask immediately.

Dimexide for acne

The easiest way to use it for acne is to daily wipe the acne- areas with Dimexide solution (DMSO concentration - no more than 10%). The procedure is repeated twice a day.

However, reviews indicate that better results can be achieved using more complex mixtures.

You can dissolve two Erythromycin in a 10% solution of the drug, or you can mix four tablespoons of concentrate with 50 ml of two percent salicylic alcohol , 40 ml of glycerin and the contents of 10 ampoules of a ten percent solution of Dioxidin.

Both formulations should be applied to problem areas of the skin twice a day.

A very powerful remedy for acne is a composition prepared from 40 ml of salicylic alcohol (2%), 10 tablets of Metronidazole , 10 capsules of Doxycycline , and 10 ml of Dimexide (the concentrate is added last).

Dimexide for cellulite

The drug has a vasodilating effect and helps restore metabolic processes throughout the body, which allows it to be used to combat cellulite.

To reduce the “orange peel”, the product is used in the form of applications and compresses, after mixing with distilled water. Optimal proportions are selected depending on the zone for which the drug will be used.

For the thighs, the concentrate is diluted with water in a ratio of 1:1, for the armpits, neck and arms - in a ratio of 1:20 or 1:10.

Then gauze soaked in the resulting solution is applied to problem areas, covered with polyethylene, insulated and left on the skin for 50 minutes. The course is designed for 12-15 procedures.

Alginate wraps with Dimexide and wraps with Dimexide and seaweed are very popular in cosmetology.

Before starting the wrap, it is recommended to take a warm shower (or bath) and cleanse the skin with a fine-grained scrub. Then the skin of problem areas of the body is wiped with a cotton pad soaked in Dimexide solution.

For women with sensitive skin, the drug should be diluted with one volume of concentrate in three volumes of distilled or boiled water. If there is no allergy to the medicine, it is used in its pure form.

To treat the legs and abdomen, 1 teaspoon of solution is enough. After applying Dimexide, an anti-cellulite agent is rubbed into the skin. When it is absorbed, begin preparing the alginate. Since the drug hardens quickly, it should be prepared very quickly.

Alginate diluted in water is distributed over the skin, wrapped on top with two layers of foil (cling film) and a terry towel. Exposure time is from 40 minutes to one hour. There is no need to rinse off the product after wrapping. Simply apply cosmetic milk or moisturizer to your legs and stomach.

Seaweed wraps are made using the same principle.

How to dilute Dimexide for boils

Inflammation of the skin glands, which develop into boils, is often accompanied by a local increase in temperature and tension on the skin surface. In order to relieve pain and reduce tissue tension due to growing inflammation, dilute Dimexide in warm water in the proportion of 1 ml of concentrate per 10 ml of clean water. Cotton pads are soaked in the resulting solution and applied to the boils. It is important not to rub, rub, or knead an unruptured boil. Safe use is considered to be simply applying a moistened swab to the inflamed area.

Interaction

DMSO increases absorption and enhances the effects of a number of other drugs (including insulin) and ethanol.

Compatible with NSAIDs, antibacterial drugs , heparin .

Increases the sensitivity of microflora to beta-lactam antibiotics and aminoglycosides , rifampicin , chloramphenicol , griseofulvin .

Sensitizes the body to general anesthesia.

Dimexide gel for external use approx. 500 mg/g 40 g tube No. 1

International nonproprietary name Dimethyl sulfoxide Dimethyl sulfoxide Synonyms None Pharmacotherapeutic group Preparations for external use for pain syndrome in diseases of the musculoskeletal system. Preparations for the treatment of skin diseases. Composition: 100 g of gel contains 25 g or 50 g of dimethyl sulfoxide. ATX code: M02AX03.

Pharmacological action Pharmacodynamics Anti-inflammatory drug for external use, inactivates hydroxyl radicals, improves the course of metabolic processes in the source of inflammation. It has a local anesthetic and analgesic effect. It has moderate antiseptic and fibrinolytic effects. When applied topically, it quickly and well penetrates biological membranes, including the skin, mucous membranes, and the membrane of microbial cells (increases their sensitivity to antibiotics). It also performs a transport function, ensuring deep penetration of other drugs through the skin and mucous membranes. Pharmacokinetics When applied to the skin and mucous membranes, it is quickly and almost completely absorbed. Bioavailability is 60-70%, and the degree of bioavailability and penetration depth are directly proportional to the concentration of dimethyl sulfoxide. When applied locally to the skin, it is detected in the blood serum within 10 minutes after application, peak concentration is observed after 4-8 hours. Penetrates well into tissue cells of all organs, with the exception of hair, nails and tooth enamel. Metabolized by oxidation to methylsulfonylmethane, followed by reduction to dimethyl sulfide. Dimethyl sulfoxide and its metabolites are excreted in urine and feces. Dimethyl sulfoxide can also be excreted through the skin and lungs, which is accompanied by a specific garlic odor. Accumulation of dimethyl sulfoxide and its metabolites in the body does not occur with long-term use of the drug.

Indications for use Complex therapy of rheumatoid arthritis, ankylosing spondylitis, osteoarthritis (in the presence of damage to periarticular tissues), radiculitis, scleroderma, erythema nodosum, erysipelas; bruises, sprains, inflammatory swelling; infiltrates (including traumatic); purulent wounds, burns, trophic ulcers, thrombophlebitis, eczema, acne, complex therapy of pyoderma, furunculosis; in skin plastic surgery, transplanted skin auto- and homografts, preservation of skin homografts; in dentistry, inflammatory diseases of the maxillofacial area, salivary glands, periodontitis, pulpitis, periodontitis, arthritis and osteoarthritis of the temporomandibular joint.

Method of administration and dosage regimen The drug is used cutaneously, in the form of applications. Apply a thin layer of 50% dimexide gel to the affected areas of the skin (on the face and other particularly sensitive areas of the body), as well as 25% dimexide gel to the mucous membranes and rub easily. Applications are carried out 2-3 times a day for 10-15 days. For eczema, diffuse streptoderma, as well as for local anesthesia for pain syndromes, it is possible to apply 50% gel in the form of compresses to the affected areas 2-3 times a day. For thrombophlebitis in combination with heparin ointment 100 units or heparin gel 1000 units in the form of simultaneous applications 2-3 times a day for 10-15 days. In skin plastic surgery, dressings with 25% dimexide gel are used on transplanted skin auto- and homografts immediately after surgery and in the subsequent days of the postoperative period until stable engraftment of the graft.

Special instructions Considering the possibility of individual intolerance to the drug, it is recommended to carry out a drug tolerance test. To do this, dimexide gel is applied to a small area of ​​skin on the back of the wrist. The appearance of severe hyperemia and itching indicates increased sensitivity to the drug.

Side effects The drug is usually well tolerated, but some patients may experience itchy dermatitis, erythema, and a feeling of dry skin. In isolated cases, bronchospasm is possible. Some patients do not perceive the smell of the drug well, which may be accompanied by nausea and vomiting.

Contraindications The use of the drug is contraindicated in cases of hypersensitivity, severe hepatic and/or renal failure, angina pectoris, severe atherosclerosis, glaucoma, cataracts, myocardial infarction, stroke, coma, pregnancy and lactation (breastfeeding must be stopped during the treatment period).

Precautions Prescribed with caution to patients with a history of allergies, as well as to persons suffering from coronary heart disease. Due to the fact that dimethyl sulfoxide can enhance not only the activity, but also the toxicity of some drugs, caution should be exercised when prescribing it simultaneously with other drugs for topical use.

Interaction with other drugs Increases absorption and enhances the effect of ethanol and insulin. Increases absorption and increases the effect of other co-applied drugs. Compatible with heparin, antibacterial drugs, non-steroidal anti-inflammatory drugs. Increases the sensitivity of microorganisms to aminoglycosides and beta-lactam antibiotics, chloramphenicol, rifampicin, griseofulvin. Sensitizes the body to the action of drugs for general and local anesthesia.

Overdose Cases of overdose of the drug when applied topically in recommended doses have not been described. Release form Gel 25% in aluminum tubes of 40 g. Gel 50% in aluminum tubes of 40 g.

special instructions

Some patients smell garlic in the air they breathe.

To determine possible individual intolerance to the drug, before using it, it is recommended to conduct a drug test (the solution is applied to the skin and the patient’s reaction is observed).

Evidence of increased sensitivity is itching and severe redness of the skin.

If during treatment with Dimexide the patient experiences allergic reactions , he should be prescribed an antihistamine .

Non-medical use of the drug or how to clean polyurethane foam?

One of the little-known properties of Dimexide is its ability to remove hardened polyurethane foam well.

To do this, the concentrate should be applied to a cotton swab or sponge, rub it into the surface on which the foam has fallen, and wait a few minutes until the foam begins to become covered with a well-peeling crust. If necessary, the manipulations are repeated several times.

It is necessary to work with rubber gloves so as not to burn the skin of your hands.

How to treat a burn from Dimexide?

You can get a burn from Dimexide if the drug is diluted incorrectly, as well as if it is used undiluted.

Photo of a burn with Dimexide:

What to do in case of a burn? A cabbage leaf applied to the burned area is good for soothing irritated skin (it can be secured with a bandage on top).

Panthenol diluted in water at room temperature . In case of severe burns, you can use ointment with corticosteroids ( Hydrocortisone or Prednisolone ).

Analogs

Level 4 ATX code matches:
Dolobene

Nayatoks

Finalgon

Apizartron

Bee venom

Gavkamen

Menthol oil

Gum turpentine

Capsicam

Tizol

Camphor alcohol

Turpentine ointment

Formic alcohol

Mataren Plus

Dimethyl sulfoxide

Fast Relief

Synonyms: Dimexide-Lugal , Dimexide Zhff , Dimethyl sulfoxide .

Analogs with a similar mechanism of action: Alvipsal , Apifor , Artran , Boromenthol , Viprosal , Medical bile , Diclogen , Camphor alcohol , Camphor (ointment/oil), Capsicam , Carmolis , Kolkhuri , Kim , Mataren , Kuznetsov ointment , Pikhtanol , Revma-gel , Chondroxide , Honsurid , Chondroitin , Espol , Eftimethacin .

Reviews of Dimexide

Dimexide is a drug with unique chemical properties. Numerous reviews from doctors confirm the versatility of this remedy.

Dimexide quickly relieves inflammation, relieves pain well, restores the nutritional processes of cells and tissues, improves blood flow in blood vessels, has an antibacterial effect and promotes the dissolution of blood clots.

These properties make it possible to use Dimexide for the treatment of diseases of the musculoskeletal system (compresses are very effective for arthrosis of the ankle or knee joints ) and diseases of the upper respiratory tract , as well as infectious and inflammatory diseases in gynecology .

Reviews of the Dimexide gel are also positive: the product very quickly stops the inflammatory process, removes pus, treats acne, contusions, bruises, osteoarthritis , purulent wounds and thrombophlebitis .

Dimexide is also successfully used in cosmetology. Solcoseryl mask is an excellent alternative to expensive procedures for facial rejuvenation, and reviews of Dimexide for hair allow us to conclude that the use of the drug is one of the most affordable and effective ways to strengthen and activate hair growth.

There are a lot of good reviews about Dimexide for acne. The product “works” both independently and in combination with antibiotics . Some girls add concentrate (a few drops) to clay masks.

As a result, the skin brightens, inflammation dries out, and recovery of the affected areas is accelerated.

Another category of reviews is reviews of Dimexide for cellulite. The product works really well on orange peel. The effect of wraps and applications becomes noticeable after just a couple of procedures, while Dimexide costs significantly less than most anti-cellulite products.

Summarizing the reviews, we can draw the following conclusion - Dimexide is indispensable in a home medicine cabinet, but when using it for cosmetic purposes, it is very important to remember that this is primarily a medicine that has contraindications and can cause allergies and burns.

How much does Dimexide cost in a pharmacy?

Cost of the drug in Russian pharmacies

The price of Dimexide in ampoules (bottles) of 50 ml in Russian pharmacies is from 22 rubles. The cost of 100 ml bottles is from 36 rubles. The price of Dimexide gel is 172 rubles.

Price of Dimexide in Ukraine

The price of Dimexide solution (50 ml) is from 12 UAH. You can buy a 100 ml bottle of concentrate for an average of 21 UAH. Ukrainian pharmaceutical companies do not produce ointment (gel) Dimexide.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Dimexide conc.
  for prig solution for external use. approx. 99% fl. 100ml JSC Tatkhimfarmpreparaty 135 rub. order
• Dimexide gel for external use applications 25% 30gLLC AVZ S-P/Pharmamed LLC

  RUB 209 order

Pharmacy Dialogue

• Dimexide gel (tube 25% 30g) Farmamed

  RUB 191 order

• Dimexide (bottle 100ml) TCPP

  RUB 179 order

• Dimexide (100ml bottle (plastic))Iodine technologies and marketing

  175 rub. order

• Dimexide (bottle 100ml) Tula FF

  162 RUR order

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Pharmacy24

• Dimexide 50 ml solution PAT "Lubnipharm", Ukraine
  12 UAH. order
• Dimexide 50 ml solution PAT "Galichfarm", Ukraine

  15 UAH order

• Dimexide 50 ml solution TOV "DKP Pharm.Fabrika", Ukraine

  12 UAH order

• Dimexide 100 ml solution PAT "Lubnipharm", Ukraine

  21 UAH order

PaniPharmacy

• DIMEXID liquid Dimexide 50ml Ukraine, Galichfarm JSC

  16 UAH order

• DIMEXIDE liquid Dimexide liquid 50ml fl. Ukraine, Lubnyfarm PJSC

  13 UAH order

• Dimexide liquid Dimethyl sulfoxide 50ml Ukraine, GEZMP GP

  17 UAH order

• DIMEXIDE liquid Dimexide liquid 100ml fl. Ukraine, Lubnyfarm PJSC

  24 UAH order

• Dimexide liquid Dimexide solution for external approx. 50ml Ukraine, Zhytomyr FF LLC

  14 UAH order

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