"Dona" is an effective drug containing glucosamine. Used to treat osteochondrosis, osteoarthritis. Promotes the restoration of cartilage and bone tissue, improves the permeability of joint capsules. Many patients (more than 80%) note the cessation of pain after several months of use. The course of therapy is long, you must first consult a doctor.
“Dona” stimulates tissue repair (elimination of damage). The active ingredient is glucosamine. Performs the functions of an analgesic and anti-inflammatory agent. Has a complex effect on joints:
- increased permeability of the joint capsule;
- replenishment of glucosamine deficiency;
- increased proteoglycan synthesis;
- increased synthesis of hyaluronic acid, which is contained in synovial fluid;
- restoration of metabolism in articular cartilage and synovial membranes;
- stimulation of chondroitinsulfuric acid synthesis;
- improving calcium absorption by bones;
- preventing the destruction of joints and bones;
- reduction of joint pain.
The drug is almost completely (90%) absorbed from the gastrointestinal tract, which ensures a biavailability level of 25%.
The product is produced in the form of tablets weighing 750 mg each and powder (1500 mg). Sold in pharmacies, dispensed without a prescription. Should be stored at room temperature (up to 25 degrees) for a total shelf life of 3 years from the date of production.
Pharmacological properties of the drug Dona
Pharmacodynamics . A drug that affects metabolic processes in cartilage tissue. Glucosamine sulfate is a salt of the natural aminomonosaccharide glucosamine with low molecular weight, carefully purified from macromolecular components. The drug replenishes the endogenous deficiency of glucosamine, stimulates the synthesis of proteoglycans and hyaluronic acid in synovial fluid. Increases the permeability of the joint capsule, restores enzymatic processes in the cells of the synovial membrane and articular cartilage. The anti-inflammatory effect of glucosamine sulfate is due to blocking the formation of superoxide radicals by macrophages and inhibition of lysosomal enzymes, interleukin 1, collagenase, phospholipase A2, which leads to a slowdown in structural damage to articular cartilage, which has been repeatedly proven in long-term clinical studies. The drug promotes the fixation of sulfur in the process of chondroitinsulfuric acid synthesis and normal calcium deposition in bone tissue. Inhibits the development of degenerative processes, reduces the severity of joint pain and restores their function. Sulfates are also involved in the synthesis of glycosaminoglycans and the metabolism of cartilage tissue. The sulfate ester side chains of proteoglycans play an important role in maintaining the elasticity and water retention capacity of the cartilage matrix. A decrease in the severity of clinical symptoms is usually noted 2 weeks after the start of treatment, with clinical improvement continuing for 8 weeks after discontinuation of the drug. The results of clinical studies of continuous therapy with the drug for 3 years indicate a progressive increase in its effectiveness, expressed in regression of disease symptoms and slowdown of structural damage to articular cartilage, confirmed by X-ray. Glucosamine sulfate is well tolerated, with no significant effects on the cardiovascular, respiratory or central nervous system. Lidocaine hydrochloride is a local anesthetic that is used to reduce pain when the drug is administered intramuscularly. Pharmacokinetics . Glucosamine sulfate is quickly and completely absorbed in the small intestine (90%). Easily passes through biological barriers and penetrates tissue, mainly articular cartilage. Bioavailability - 26%. The half-life of the drug is 68 hours.
Risk group for spinal diseases
I often heard from friends that they play sports and eat normally, so they cannot get all kinds of arthritis and arthrosis. To be honest, for some time I thought that the risk of illness depended only on lifestyle. It turned out that everything was completely wrong. Of course, if you eat only fast food and don’t get off the couch, then the probability of bone deformation is close to 100%, but everyone is at risk! Athletes, vegetarians and doctors also get sick, and quite often.
How did I understand that I needed to start taking pills and why Dona?
I won’t delve into the detailed history of my own life, I’ll just write that after 40 I began to periodically complain of headaches, chronic fatigue, crunching in the limbs and numbness in the fingers. At first I suspected a problem with the blood vessels. I thought the blood was not circulating well. I went to the cardiologist. The doctor listened to me and referred me to a surgeon.
“You have cervical osteochondrosis in the initial stage.
Most likely, the disease developed due to low mobility, plus some bad habits played a role. It's okay - everything can be fixed. You need to start taking medications, do special gentle exercises and sign up for physical therapy. Let’s start therapy with Don’s tablets and look at the results...” Roman Igorevich, surgeon, chiropractor, Murmansk
I thought, but I really worked as a driver for many years (low mobility, poor posture), I live far from a southern resort (frequent hypothermia), I smoke, sometimes drink (bad habits), and there is often stress - predisposing factors are obvious. I decided that I would start treatment without delay.
Use of the drug Dona
Orally, for adults and elderly patients, 1 sachet (1.5 g) 1 time per day for 4–12 weeks or longer (if necessary). Before use, the contents of the sachet are dissolved in 200 ml of water and taken with meals. The course of treatment can be repeated 2-3 times a year with an interval of 2 months, as well as in case of relapse of the disease. The solution is intended for intramuscular administration only! Before use, mix the solvent (solution B) with the drug (solution A) in one syringe. The prepared solution is administered to adults intramuscularly, 3 ml 3 times a week for 4–6 weeks. Injections can be combined with oral administration of the drug.
“Don” tablets
I always suspected that I would develop some kind of bone disease. I have bad heredity and a lot of bad habits (for example, I like to crunch my fingers). That is why, after the onset of discomfort in the spine, I immediately went to see a doctor. I know that you need to start treatment as early as possible. The doctor prescribed me Don tablets (I ordered them on the online pharmacy website) and a special set of exercises. Now, after the first course of the drug, it has become much easier and it makes me happy! In general, I briefly described the situation to you, now I’ll try to go through the points in more detail)))
Special instructions for the use of Dona
Glucosamine, which is part of the drug, is obtained from shellfish shells, so if you are allergic to shellfish, the drug should be used with caution. The drug in powder form for oral use contains sorbitol, so it is not used for fructose intolerance. Patients on a sodium-restricted diet should be aware that the oral dosage form contains sodium (151 mg per 1.5 g daily dose). In case of diabetes mellitus, it is advisable to control glycemia at the beginning of therapy. In case of severe renal and liver failure, the drug is prescribed under the supervision of a physician. Adequate studies of the safety and effectiveness of the drug in children under 12 years of age, as well as during pregnancy and lactation, have not been conducted. The drug does not affect the ability to drive vehicles or operate machinery .
Overdose and drug interactions
No cases of overdose have been identified. If the dose is violated, immediate gastric lavage and treatment are indicated depending on the symptoms that arise. The drug should be used with caution in patients who are allergic to various types of seafood. If the patient is on a sodium diet, he needs to follow the dosage, since one Dona tablet contains 75 mg of pure sodium.
The product is compatible with various drugs:
- glucorticosteroids;
- non-steroidal anti-inflammatory drugs;
- paracetamol and drugs based on it.
Parallel use with antibiotics leads to an increase in the therapeutic effect of drugs of the tetracycline group and a weakening of semisynthetic penicillin, as well as chloramphenicol. It is also possible to enhance the effect of coumarin anticoagulants.
Price for Don's medicine, where to buy
The price of Dona tablets No. 60 averages 1,350 rubles per pack; solution in ampoule No. 6 - 1282 rubles; Dona powder No. 30 - 1130 rubles per package.
You can purchase the drug at a pharmacy chain in Moscow or make a pre-order for the drug.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
LuxPharma* special offer
- Simidona Forte tab.
13 mg No. 30 RUR 2,370 order
ZdravCity
- Dona tablets p.p.o. 750 mg 180 pcs. Madaus GmbH
RUB 2,936 order
- Dona tablets p.p.o. 750 mg 60 pcs. Madaus GmbH
RUB 1,491 order
- Dona solution for intramuscular injection. 200mg/ml 2ml 6 pcs. (+ solvent 1 ml 6 pcs.) Biologichi Italy Laboratories S.r.l./Rottafarm S.p.A
RUB 1,529 order
Pharmacy Dialogue
- Dona tablets 750 mg No. 60Madaus
RUB 133 order
- Dona tablets 750 mg No. 60Madaus
RUB 1,484 order
- Dona ampoules 200mg/ml 2ml No. 6Biologici
RUB 1,468 order
- Dona tablets 750 mg No. 180Madaus
RUB 2877 order
- Dona powder 1.5g No. 20Rottapharm
RUB 1,544 order
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Pharmacy24
- Dona 2 ml N6 solution Rottapharm S.p.A./Biologichi Italy Laboratories S.r.L., Italy
700 UAH.order - Simidona Uno 6.5 mg No. 30 tablets Ginsana SA, Switzerland/Max Celler Sion AG, Switzerland/Labor Zollinger AG, Switzerland/Interlab Belp
167 UAH order
- Simidona forte 13 mg No. 30 tablets Ginsana SA, Switzerland/Max Celler Sion AG, Switzerland/Labor Zollinger AG, Switzerland/Interlab Belp
251 UAH order
- Dona 1500 mg N20 powder Rottafarm Ltd., Ireland
700 UAH. order
PaniPharmacy
- Drainage catheter Redona with adapter CH-18 Ukraine, Kammed
27 UAH order
- Simidona Forte tablets Simidona Forte tablets. 13mg No. 30 Switzerland, Max Zeller Sohne
237 UAH order
- Dona ampoule Dona injection solution ampoules 2 ml with solvent in ampoules 1 ml No. 6 Italy, Biologici Italia Lab.
676 UAH. order
- Drainage catheter Redona CH-30 Ukraine, Kammed
27 UAH order
- Simidona uno tablets Simidona uno tablets 6.5 mg No. 30 Switzerland, Max Zeller Sohne
211 UAH order
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Composition and principle of action of the chondroprotector
I was wondering how Don's pills work. First of all, I downloaded the instructions on the Internet and started reading the ingredients. I'm not good at chemistry, but I didn't have to look into it too much. The drug is made from glucosamine, plus several additional substances for normal absorption. It turns out that treatment comes down to restoring the natural structure of cartilage tissue.
It turned out that the treatment of diseases of the musculoskeletal system is quite specific. The infection needs to be killed with antibiotics, but diseases of the spine require activation of normal metabolism and, if possible, tissue regeneration. This is where Don's drug helps! It has been proven that dosed administration of a chondroprotector can slow down the destruction of cartilage and eliminate the unpleasant symptoms of arthritis, arthrosis and osteochondrosis.
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