Indications for use Chondromarin
- joint diseases (arthrosis, arthritis and polyarthritis, osteochondrosis, etc.);
- damage to tendons and ligaments;
- damage to intervertebral discs (protrusion, hernia);
- recovery from joint injuries;
- with high loads on the joints for the purpose of prevention (sports);
- dental operations.
Can be used in sports with high loads on the joints, as well as for arthrosis, arthritis (polyarthritis), osteochondrosis, and joint injuries. It has antitumor activity and can be used in oncology as an adjuvant.
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Back pain can be vertebrogenic (degenerative-dystrophic changes: osteochondrosis, spondyloarthrosis, trauma, osteoporosis, primary and metastatic tumors, spondylitis, rheumatoid arthritis, ankylosing spondylitis) and non-vetebrogenic nature (musculoskeletal, neuropathic, vascular, viscerogenic and psychogenic pain) .[1].
One of the main causes of back pain is degenerative damage to the facet (facet) joints, accompanied by stretching and pinching of their capsule, degeneration and subsequent ossification of the ligamentous apparatus of the spine. Pain resulting from damage to the facet joints is often local (nociceptive) in nature, less often – myofascial or radicular.
Currently, a large number of studies related to chronic back pain are being conducted, and one of them shows that 40% have facet pain syndrome, 26% have discogenic pain, 2% have pain associated with the sacroilial joint, 13% have due to irritation of segmental dural nerves. [4]
Treatment of patients with chronic back pain caused by facet syndrome requires an integrated approach to treatment and the prescription of various pharmacological groups of drugs.
The approach to pain management in the elderly requires the simultaneous consideration of many factors. An important principle is the combination of pharmacological and non-pharmacological therapy (kinesitherapy, physiotherapy, massage) and rational psychotherapy.
In our opinion, one of the most optimal methods for treating exacerbation of chronic back pain in the elderly is the use of NSAIDs in combination with chondroprotectors (chondroitin sulfate).
Chondroitin sulfate is the main component of proteoglycans, which together with collagen fibers make up the cartilage matrix. Has chondroprotective properties; inhibits the activity of enzymes that cause degradation of articular cartilage; stimulates the production of proteoglycans by chondrocytes; enhances metabolic processes in cartilage and subchondral bone; influences phosphorus-calcium metabolism in cartilage tissue, stimulates its regeneration, and participates in the construction of the basic substance of bone and cartilage tissue. Chondroitin sulfate - has anti-inflammatory and analgesic properties2. The drug helps restore the cartilaginous surfaces of joints and prevents the collapse of connective tissue; normalizes the production of joint fluid, which leads to improved joint mobility and reduced pain intensity. Chondroitin sulfate is easily absorbed when administered intramuscularly. The maximum concentration is reached 1 hour after administration. The drug accumulates in the synovial fluid. It is excreted from the body mainly by the kidneys within 24 hours.
According to observation, there were 2 groups of patients with a diagnosis: Chronic wind-brogenic thoracalgia, exacerbation stage. Myofascial syndrome. Spondyloarthrosis, osteochondrosis of the thoracic spine.
Purpose of the study: to evaluate the effectiveness and safety of the use of Chondroitin sulfate (CS) in stepwise therapy of vertebrogenic thoracalgia in elderly patients with spondyloarthrosis.
Group 1 (10 patients) received Chondroitin sulfate 2 ml (200 mg), paravertebral intramuscularly, divided into 6 points and administered to trigger points, every other day for 10 days, in combination with NSAIDs (Lornoxicam) intramuscular/intravenous administration and physiotherapeutic treatment.
Group 2 (10 patients) received only NSAIDs (Lornoxicam), intramuscular/intravenous administration, in combination with physiotherapeutic treatment.
All patients underwent X-ray examinations to identify degenerative changes (osteochondrosis, spondyloarthrosis, spondylosis) of the spine (computed tomography - 3, magnetic resonance imaging - 7). The intensity of pain was assessed using the Visual Analogue Scale (VAS) and was 5.4 and 5.3 points in groups 1 and 2, respectively.
In the first group, on days 4-5, patients noted a significant decrease in pain, an increase in the range of motion in the thoracic and lumbar spine, a decrease in morning stiffness, and a decrease in pain on the VAS scale by 1 - 2 points. On day 10, the pain syndrome was reduced, morning stiffness and limited mobility in the thoracic spine remained. In the second group, only on days 9-10, patients noted a decrease in pain, on the VAS scale by 3-4 points, a decrease in morning stiffness, and an increase in the range of movements. There was no complete reduction of pain in the second group.
There were no undesirable effects with the administration of cholesterol. Tolerability of the drug is satisfactory. After a course of inpatient treatment, patients in group 1 received cholesterol on an outpatient basis intramuscularly for 10 days every other day, at a daily dosage of 2 ml (200 mg), followed by a transition to the tablet form of the drug for 6 months. Patients in group 2 received oral cholesterol supplementation for 6 months after discharge from the hospital.
Follow-up after 3 months: in group 1, positive dynamics were noted in the form of a decrease in pain on the VAS scale to 1.5 points, and a significant increase in motor activity. In group 2, positive dynamics were observed in the form of a decrease in pain on the VAS scale to 2.3 points, and a decrease in morning stiffness in the thoracic spine.
Thus, complex treatment of facet syndrome in the thoracic spine using paravertebral intramuscular injection of cholesterol in a combination of NSAIDs leads to a more rapid reduction in pain, shortening the patient’s hospital stay and restoration of daily activity.
Effects and mechanism of action
The active ingredients of Chondromarin ensure the restoration of cartilage, bones and connective tissue. The structure of cartilage tissue, intervertebral discs, and bone tissue is restored. The presence of enzymes - subtilisins - eliminates chronic inflammation, as a result of which the pain syndrome subsides. Prolongs remission in degenerative diseases of the joints and spine. Has antitumor activity.
The enzymes in Chondromarin “cleanse” the vascular bed of inflammatory receptors, microthrombi and destroy proteins of dead cells. However, they do not affect the proteins of healthy cells. The pain goes away along with the inflammation.
Until recently, the main disadvantage of all enzyme preparations was that they are not absorbed into the blood, and their action is limited only to the intestinal lumen (therefore, it was previously believed that injection preparations were more effective). successfully solved this problem. Thanks to the unique patented Axis technology, all drugs processed using this technology penetrate cellular barriers and enter the bloodstream, even when taken in capsule form. Thus, systemic enzyme therapy became possible. Patients do not need to undergo injections, just take the capsule.
Chondromarin is absorbed into the blood when taken orally, completely retaining its properties. A complex of enzymes isolated from Bacillus subtillius destroys all known protein toxins in the human body. When entering the blood, enzymes “cleanse” the vascular bed of inflammatory receptors, microthrombi and destroy proteins of dead cells. However, they do not affect the proteins of healthy cells.
Oligonucleotides in the composition of Chondromarin - this valuable substance (of natural origin) is a building material for our own cells, especially for sick (damaged) cells of our body during periods of chronic diseases. Oligonucleotides have an anti-inflammatory effect, restore metabolism, and suppress autoimmune processes. Effects: necrolytic (destruction of proteins of non-viable damaged cells), thrombolytic (destruction of formed vascular blood clots), mucolytic (expectorant), diuretic (diuretic).
Glucosamines (biologically active substances of salmon cartilage), which are part of the drug, have long been known to medicine and are used in the treatment of diseases of the joints and spine, oncological diseases and in sports medicine.
Chondroitin sulfate has anti-inflammatory activity, reduces pain, and improves the functional state of joints.
Collagen and free amino acids provide stimulation of metabolic processes in connective tissue.
The biologically active substances contained in Chondromarin restore cartilage tissue, and Axis technology allows you to increase the effectiveness of the drug several times - beneficial substances easily enter the blood and are delivered to the cell.
Chondromarin can be used in sports with high loads on the joints, as well as for arthrosis, arthritis (polyarthritis), osteochondrosis, and joint injuries.