Description of the drug IBUFEN ULTRA
With simultaneous use, ibuprofen reduces the effect of antihypertensive drugs (ACE inhibitors, beta-blockers), diuretics (furosemide, hydrochlorothiazide).
When used simultaneously with anticoagulants, their effect may be enhanced.
When used simultaneously with GCS, the risk of side effects from the gastrointestinal tract increases.
When used simultaneously, ibuprofen can displace indirect anticoagulants (acenocoumarol), hydantoin derivatives (phenytoin), and oral hypoglycemic drugs, sulfonylurea derivatives, from compounds with blood plasma proteins.
When used simultaneously with amlodipine, a slight decrease in the antihypertensive effect of amlodipine is possible; with acetylsalicylic acid - the concentration of ibuprofen in the blood plasma decreases; with baclofen - a case of increased toxic effects of baclofen has been described.
When used simultaneously with warfarin, an increase in bleeding time is possible; microhematuria and hematomas were also observed; with captopril - the antihypertensive effect of captopril may be reduced; with cholestyramine - a moderate decrease in the absorption of ibuprofen.
When used simultaneously with lithium carbonate, the concentration of lithium in the blood plasma increases.
When used simultaneously with magnesium hydroxide, the initial absorption of ibuprofen increases; with methotrexate - the toxicity of methotrexate increases.
The simultaneous use of NSAIDs and cardiac glycosides can lead to worsening heart failure, a decrease in glomerular filtration rate and an increase in the concentration of cardiac glycosides in the blood plasma.
There is evidence of the likelihood of an increase in the concentration of methotrexate in the blood plasma during the use of NSAIDs.
With simultaneous use of NSAIDs and cyclosporine, the risk of nephrotoxicity increases.
NSAIDs may reduce the effectiveness of mifepristone, so taking NSAIDs should be started no earlier than 8-12 days after stopping mifepristone.
Concomitant use of NSAIDs and tacrolimus may increase the risk of nephrotoxicity.
Concomitant use of NSAIDs and zidovudine may lead to increased hematotoxicity. There is evidence of an increased risk of hemarthrosis and hematomas in HIV-positive patients with hemophilia who received concomitant treatment with zidovudine and ibuprofen.
In patients receiving concomitant treatment with NSAIDs and quinolone antibiotics, the risk of seizures may increase.
In patients receiving concomitant NSAIDs and myelotoxic drugs, hematotoxicity increases.
With the simultaneous use of ibuprofen and cefamandole, cefoperazone, cefotetan, valproic acid, plicamycin, the incidence of hypoprothrombinemia increases.
With the simultaneous use of ibuprofen and drugs that block tubular secretion, there is a decrease in excretion and an increase in plasma concentration of ibuprofen.
With the simultaneous use of ibuprofen and inducers of microsomal oxidation (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants), there is an increase in the production of hydroxylated active metabolites and an increased risk of developing severe intoxications.
Ibufen ultra capsules 200 mg N10
IBUFEN ultra International nonproprietary name of the drug Ibuprofen
Composition Each capsule contains: active ingredient: ibuprofen 200 mg excipients: macrogol 600 (E1521), potassium hydroxide (E525), purified water. Gelatin capsule: liquid maltitol (E965), liquid sorbitol, non-crystallizing (E420), gelatin (E441), patent blue dye (E131), purified water.
Description Oval-shaped gelatin capsules with a translucent blue shell containing a viscous liquid.
Dosage form Soft gelatin capsules
Pharmacotherapeutic group Nonsteroidal anti-inflammatory and antirheumatic drugs, propionic acid derivatives. ATS code: M 01 AE 01
Pharmacological properties Ibuprofen is a derivative of propionic acid. It has analgesic, antipyretic and anti-inflammatory effects. The mechanism of action of ibuprofen is primarily due to the suppression of prostaglandin biosynthesis by reducing the activity of cyclooxygenase (COX), an enzyme that regulates the conversion of arachidonic acid into prostaglandins, prostacyclin and thromboxane. At the same time, as a result of irreversible inhibition of the cyclooxygenase pathway of arachidonic acid metabolism, the formation of prostaglandins decreases. A decrease in the concentration of prostaglandins at the site of inflammation is accompanied by a decrease in the formation of bradykinin, endogenous pyrogens, other biologically active substances, oxygen radicals and NO. All this leads to a decrease in the activity of the inflammatory process (anti-inflammatory effect of ibuprofen) and is accompanied by a decrease in pain reception (analgesic effect). A decrease in the concentration of prostaglandins in the cerebrospinal fluid leads to normalization of body temperature (antipyretic effect). Ibufen ultra soft gelatin capsules contain ibuprofen in liquid form. Gelatin capsules ensure high dosing accuracy of the substances placed in them. The capsule shell protects the active substance from light, air and moisture, and also eliminates the unpleasant taste and smell of the medicinal substance when taken. The capsule disintegrates in the gastrointestinal tract faster than dragees and tablets, and its liquid contents are absorbed faster and more easily by the human body, ensuring high bioavailability of ibuprofen. After oral administration, more than 80% of ibuprofen is absorbed from the digestive tract. 90% of the drug binds to blood plasma proteins (mainly albumin). The period to achieve maximum concentration in blood plasma when taken on an empty stomach is 45 minutes, when taken after meals - 1.5-2.5 hours; in synovial fluid - 2-3 hours, where higher concentrations are created than in blood plasma. The drug does not accumulate in the body. Ibuprofen is metabolized mainly in the liver. Subject to presystemic and postsystemic metabolism. After absorption, about 60% of the pharmacologically inactive R form of ibuprofen is slowly transformed into the active S form. 60-90% of the drug is excreted by the kidneys in the form of metabolites and products of their combination with glucuronic acid, to a lesser extent, with bile and no more than 1% is excreted unchanged. After taking a single dose, the drug is completely eliminated within 24 hours.
Indications for use Increased body temperature of various origins with: - colds, - acute respiratory viral infections, - influenza; - sore throat (pharyngitis); - childhood infections accompanied by increased body temperature; - post-vaccination reactions. Pain syndrome of various origins of weak and moderate intensity with: - ear pain due to inflammation of the middle ear; - toothache, painful teething; - headache, migraine; - painful menstruation, - neuralgia, - rheumatic pain, - muscle and joint pain, - musculoskeletal injuries.
Contraindications The drug Ibufen Ultra should not be used in case of individual hypersensitivity to any component of the drug, as well as to other non-steroidal anti-inflammatory drugs; - ever-previous manifestations of allergy symptoms in the form of a runny nose, skin rashes or bronchospastic reactions after using acetylsalicylic acid or other non-steroidal anti-inflammatory drugs; - peptic ulcer of the stomach and duodenum in the acute phase, - severe insufficiency of liver and kidney function; — blood diseases: hemophilia, hypocoagulation, hemorrhagic diathesis; - in the third trimester of pregnancy.
Interaction with other drugs Ibuprofen (as well as other drugs from the group of non-steroidal anti-inflammatory drugs) should not be used simultaneously with the following drugs: - acetylsalicylic acid or other non-steroidal anti-inflammatory drugs - the risk of side effects from the gastrointestinal tract increases, - antihypertensive drugs drugs and diuretics - drugs from the group of non-steroidal anti-inflammatory drugs can cause a decrease in the effectiveness of these drugs, - anticoagulants - limited clinical data indicate that non-steroidal anti-inflammatory drugs can enhance the effect of drugs that reduce blood clotting, - lithium and methotrexate - it has been proven that non-steroidal anti-inflammatory drugs anti-inflammatory drugs can cause an increase in plasma concentrations of both lithium and methotrexate, - zidovudine - there is evidence of an increase in bleeding time in patients taking ibuprofen and zidovudine at the same time, - mineralocorticoids, glucocorticoids - increased side effects, - sulfonylurea derivatives - increased hypoglycemic effect, - antacids and cholestyramine reduce absorption, - caffeine enhances the analgesic effect.
Special instructions Before taking Ibufen ultra, you should consult a doctor if the following have been previously confirmed: - bronchial asthma, urticaria, - liver and kidney diseases, - a history of gastric and duodenal ulcers - arterial hypertension. During long-term treatment, monitoring of the peripheral blood picture and the functional state of the liver and kidneys is necessary. When symptoms of gastropathy appear, careful monitoring is indicated, including esophagogastroduodenoscopy, a complete blood count (hemoglobin determination), and a stool test for occult blood. If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study.
Pregnancy and lactation The use of ibuprofen in the first 6 months of pregnancy requires caution and is permitted only as prescribed by a doctor, after assessing the expected benefits and possible risks. Ibuprofen should not be used in the last trimester of pregnancy. Ibuprofen may be excreted in breast milk in small quantities. There are no known cases of side effects in infants, however, it is recommended to stop breastfeeding during treatment with ibuprofen.
Impact on the ability to drive vehicles and maintain mechanical equipment There is no information on contraindications to driving and servicing machinery while taking Ibufen ultra.
Method of administration and dosage For oral use. 1 capsule contains 200 mg of ibuprofen. Adults and children over 12 years of age (over 40 kg): single dose 200-400 mg (1-2 capsules). Then, if necessary, 1-2 capsules every 4-6 hours. The maximum daily dose is 6 capsules (1200 mg ibuprofen). The minimum interval between subsequent doses is 4-6 hours. The capsule must be swallowed whole with a small amount of water. Capsules should not be cracked, sucked or chewed. When using the drug in children, the child’s weight should be taken into account for accurate dosing. The drug should not be used for more than 5 days as an analgesic and for more than 3 days as an antipyretic without medical supervision.
Overdose If you take a higher dose of the drug than recommended, you should immediately contact your doctor or pharmacist. Symptoms of overdose: abdominal pain, vomiting, lethargy, headache, tinnitus, depression, drowsiness, metabolic acidosis, coma, hemorrhagic diathesis, decreased blood pressure, convulsions, acute renal failure, liver dysfunction, tachycardia, bradycardia. High doses of ibuprofen are usually well tolerated, provided that no other drugs are used at the same time. Measures in case of overdose: gastric lavage (only within an hour after taking the drug), activated carbon, alkaline drinking, symptomatic therapy (correction of the acid-base state, blood pressure).
Side effects Side effects are classified by frequency using the following definitions: - very common: > 1/10 - common: > 1/100 to < 1/10 - uncommon: > 1/1000 to < 1/100 - rare: > 1 /10,000 to <1/1000 - very rare: <1/10,000 When using Ibufen ultra for 2-3 days, practically no side effects are observed. In case of long-term use, the following side effects may occur: From the gastrointestinal tract Uncommon: nausea, heartburn, diarrhea, abdominal pain. Rarely: vomiting, flatulence, constipation, inflammation of the gastrointestinal tract. Very rare: ulceration of the gastrointestinal mucosa, bleeding, Crohn's disease, impaired liver function. From the nervous system: Uncommon: headache; Rare: dizziness, agitation, insomnia, drowsiness. In isolated cases, hearing loss, tinnitus, and depression have been described. From the urinary system Rarely: edematous syndrome, Very rarely: acute renal failure, allergic nephritis, polyuria, cystitis. From the hematopoietic organs Very rare: anemia (including hemolytic, aplastic), thrombocytopenia and thrombocytopenic purpura, agranulocytosis, leukopenia. Allergic reactions Uncommon: skin rash, itching, urticaria, Very rare: Quincke's edema, angioedema, anaphylactoid reactions, anaphylactic shock, bronchospasm, fever, erythema multiforme exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome ), eosinophilia, allergic rhinitis. From the cardiovascular system: Heart failure, increased blood pressure, tachycardia. Any side (unusual) effects, including those not listed in the package insert, should be reported to your doctor.
Shelf life: 2 years Do not use after the expiration date indicated on the package. The medicine should be stored out of the reach of children.
Storage conditions Store in original packaging at a temperature not exceeding 25C.
Packaging Ibufen ultra, soft gelatin capsules 200 mg: 10 capsules each in a blister made of PVC/PVDC and aluminum foil. 10 (1 blister) or 20 (2 blisters) capsules together with an insert in a cardboard box.
Note!
Description of the drug Ibufen Junior caps. soft 200 mg No. 10 on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
Overdose
In childhood, overdose symptoms may occur when taking a dose of ibuprofen that exceeds 400 mg/kg. The half-life of an overdose is 1.5-3 hours.
Symptoms The majority of patients receiving clinically significant amounts of the drug developed only nausea, vomiting, epigastric pain, and very rarely diarrhea. Tinnitus, headache, and gastrointestinal bleeding may also occur. With more severe poisoning, toxic damage to the central nervous system is possible, which manifests itself as vertigo, drowsiness, and sometimes agitation and disorientation or coma. Sometimes patients experience seizures
Treatment. Treatment should be symptomatic and supportive and include maintaining the airway and monitoring cardiac and vital signs until the condition returns to normal. It is recommended to administer activated charcoal orally or gastric lavage within 1 hour after administering a potentially toxic dose of the drug.
Contraindications
- Hypersensitivity to ibuprofen.
- Hypersensitivity reactions (eg asthma, rhinitis, angioedema or urticaria) that have previously been observed after the use of ibuprofen, acetylsalicylic acid (aspirin) or other NSAIDs.
- Peptic ulcer of the stomach or duodenum/bleeding in an active form or relapse in history.
- History of gastrointestinal bleeding or perforation associated with NSAID use.
- Severe heart failure (NYHA class IV), severe renal failure or severe liver failure.
- Last trimester of pregnancy.
- Active inflammatory bowel disease.
- Cerebrovascular or other bleeding.
- Disorders of hematopoiesis or blood coagulation of unknown etiology (hemorrhagic diathesis, thrombocytopenia).
- Dehydration caused by vomiting, diarrhea, or not drinking enough fluids.
Ibufen
Ibufen (active ingredient ibuprofen) is a non-steroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic and anti-inflammatory effects. It is used mainly to reduce febrile body temperature, relieve pain of various origins, and treat inflammatory and degenerative diseases of the musculoskeletal system. A special release form - orange-flavored syrup - is provided primarily due to the “children’s” specialization of the drug. According to the American Pediatrics Association, about 30% of visits to pediatricians are due to fever. According to general recommendations, antipyretic (antipyretic) drugs can be prescribed at a body temperature of 38.5 °C and above (and in some cases - 38 °C). In this case, it is necessary to make allowances for children’s age, because not all antipyretics can be prescribed to this category of patients. A number of drugs (analgin, acetylsalicylic acid) are allowed to be used only from a certain age and according to “reinforced concrete” indications due to the risk of developing side effects. In our country, as well as abroad, one of the most popular over-the-counter antipyretic drugs is ibuprofen (ibufen). The pharmacological “biography” of ibuprofen dates back to the 70s of the last century, when the drug began to be prescribed as an anti-inflammatory drug. In a relatively short period of time, ibuprofen has become one of the most prescribed NSAIDs in both adults and children. The mechanism of action of the drug is due to its ability to suppress the activity of cyclooxygenase (COX), an enzyme that mediates the synthesis of mediators of pain and inflammation, prostaglandins. The analgesic effect of ibufen is in demand for headaches, dental pain, postoperative pain, incl. in pediatric surgery. Ibufen has a positive effect on the condition of tissues at the site of inflammation. A number of other positive effects of the drug have been proven: for example, ibufen stimulates phagocytosis, which brings tangible benefits in acute respiratory infections in children accompanied by high fever.
After oral administration, ibufen is quickly and completely absorbed from the digestive tract if taken on an empty stomach, or after 1.5-2 hours if taken after meals. The half-life of the drug is 2 hours. The low toxicity of ibufen is explained by its rapid metabolism and the absence of active metabolites: in this regard, the drug compares favorably with paracetamol. The pharmacokinetics of the drug determines some age-related features of its use. Thus, the half-life of ibufen increases as the child grows up from birth to 1-3 years. Another interesting aspect is the comparison of the effectiveness of the drug with other NSAIDs. Thus, French scientists studied the effect of ibuprofen in comparison with acetylsalicylic acid and paracetamol. Children aged from six months to two years took part in the study. The result of this scientific work was the clear conclusion that ibuprofen has the best effect in the first 6 hours.
Ibufen should be taken after meals. Before use, it is recommended to shake the bottle until a homogeneous suspension is obtained. The dose is determined by the body weight and age of the child. A single dose is on average 5-10 mg per 1 kg of body weight, the frequency of administration is 3-4 times a day, the time intervals between doses are 6-8 hours. The antipyretic effect of the drug is observed within half an hour after administration and remains at a stable level for 6-8 hours. If there is no sufficient therapeutic response in terms of fever reduction (within 2 days) or pain relief (within 3 days), it is imperative to consult a doctor. Only a doctor can prescribe ibufen to children from six months to 1 year of age, regardless of its over-the-counter status.