Troxerutin

Dosage form: gel for external use.

Composition per 100 g:

active ingredient: troxerutin (in terms of 100% substance) – 2.00 g;

excipients: carbomer 940 - 0.6 g, disodium edetate - 0.050 g, benzalkonium chloride - 0.0575 g, sodium hydroxide 30% - 0.700 g, purified water - up to 100 g.

Description: homogeneous transparent gel from yellow to light brown or yellow-green.

Pharmacotherapeutic group: venotonic and venoprotective agent.

ATX code: C05CA04.

pharmachologic effect

Pharmacodynamics. Troxerutin is a flavonoid (derivative of rutin), has P-vitamin activity: it has venotonic, venoprotective, decongestant, anti-inflammatory, anticoagulant and antioxidant effects. Its pharmacodynamic properties are associated with the participation of troxerutin in redox processes and inhibition of hyaluronidase. By inhibiting hyaluronidase, troxerutin stabilizes hyaluronic acid in cell membranes and reduces the permeability and fragility of capillaries, increasing their tone. It has antioxidant activity, which prevents the oxidation of ascorbic acid, adrenaline and lipids. Prevents damage to the basement membrane of endothelial cells when exposed to various factors. Troxerutin reduces exudative inflammation in the vascular wall, limiting the adhesion of platelets to its surface. As a result of treatment with troxerutin, the feeling of heaviness in the legs disappears, tissue swelling decreases, and trophism improves.

Pharmacokinetics. When the gel is applied to the affected area, the active substance quickly penetrates the epidermis, after 30 minutes it is found in the dermis, and after 2-5 hours in the subcutaneous fatty tissue.

Indications for use:

Varicose veins, chronic venous insufficiency, accompanied by swelling, pain, a feeling of heaviness in the legs, thrombophlebitis, periphlebitis, varicose dermatitis, pain and swelling after injuries (bruises, ligament damage).

Contraindications:

Hypersensitivity to the drug. Violation of the integrity of the skin. Children under 18 years of age (no experience of use).

with caution in chronic renal failure (long-term use).

Use during pregnancy and breastfeeding.

Pregnancy.

In preclinical studies, teratogenicity and fetotoxicity of drugs containing troxerutin were not noted. In the first trimester of pregnancy, the use of the drug Troxerutin is contraindicated due to the lack of experience in clinical use. In the second and third trimesters of pregnancy, the use of the drug Troxerutin is possible only if the expected benefit to the mother outweighs the potential risk to the child.

Breastfeeding period

There are no data on the penetration of troxerutin into breast milk. The drug Troxerutin should not be used during breastfeeding.

Directions for use and dosage:

Outwardly! A column of gel 4-5 cm long is applied in a thin layer to the affected areas and lightly rubbed in 3-4 times a day until completely absorbed. The daily dose should not exceed 20 cm of gel. If necessary, the gel can be applied under bandages or elastic stockings. The duration of treatment is no more than 10 days.

If the symptoms of the disease worsen or do not go away after 6-7 days of daily use of the drug, you should consult a doctor who will prescribe further treatment and determine the duration of the course of therapy.

Side effect:

In rare cases, allergic skin reactions are observed - urticaria, eczema, dermatitis. These symptoms disappear quickly after stopping treatment.

Overdose:

Cases of overdose with the recommended method of use of the drug are not known. If the drug is accidentally swallowed, a burning sensation in the mouth, salivation, nausea, and vomiting may occur. In this case, lavage of the oral cavity and stomach is indicated, and, if necessary, symptomatic treatment.

In case of contact with eyes, mucous membranes and open wounds, local irritation is observed - lacrimation, hyperemia, burning, pain. The gel is washed off with a large amount of distilled water or isotonic sodium chloride solution until the complete disappearance or significant reduction in the severity of these symptoms.

Interaction with drugs:

No information available.

Special instructions:

The gel is applied only to an undamaged surface.

Avoid contact with open wounds, eyes and mucous membranes!

In conditions characterized by increased vascular permeability (including scarlet fever, influenza, measles, allergic reactions), the gel is used in combination with ascorbic acid to enhance its effect.

Features of the action of the drug when first taken or when discontinued:

No information available.

Information about the possible effect of a medicinal product for medical use on the ability to drive vehicles and machinery:

Does not affect the ability to drive vehicles or operate moving machinery.

Storage conditions:

Store in a place protected from light at a temperature not exceeding 25°C. Keep out of the reach of children.

Shelf life: 2 years.

Do not use the drug after the expiration date indicated on the package.

Release form:

Gel for external use 2%.

20, 25, 30, 40, 50, 60, 70, 80, 100 g in orange glass jars with a triangular rim and a lid that is tensioned with a sealing element.

20, 25, 30, 40, 50, 60, 70, 80, 100 g in polymer jars complete with lids or in polyethylene terephthalate jars with closures.

Labels made of label or writing paper, or a self-adhesive label, are glued onto jars and cardboard boxes.

20, 25, 30, 40, 50, 60, 70, 80, 100 g in aluminum tubes, coated with BF-2 varnish, with caps made of high-density polyethylene or in polymer tubes with polyethylene screw caps.

Each jar and tube, along with instructions for use, is placed in a cardboard pack.

Vacation conditions:

Available without a prescription.

Troxerutin A-LAB toning gel-cream 2% 100ml

A country

Russia
The country of production may vary depending on the batch of goods. Please check with the operator for detailed information when confirming your order.

Compound

Water, propylene glycol, troxerutin, dicapryl ether, polysorbate 20, menthol, horse chestnut extract, lemon essential oil, carbomer, phenoxyethanol, ethylhexylglycerin, Trilon B, sodium hydroxide.

Description

Foot gel-cream is designed for effective foot skin care. Due to the content of a complex of active components, the gel helps relieve fatigue and heaviness in the legs. Troxerutin in combination with horse chestnut has a tonic and decongestant effect. The menthol included in the composition has a cooling effect and creates the effect of “light legs”. Lemon essential oil provides a deodorizing effect. The effective formula of the gel-cream for feet gives a feeling of lightness and returns a feeling of comfort to the feet.

Pharmacological properties

THE GEL CREAM INCLUDES ACTIVE COMPONENTS:
Troxerutin - a flavonoid, a derivative of rutin (vitamin P) - has a venotonic, angioprotective, decongestant and antioxidant effect.

Horse chestnut extract - contains bioflavonoids, rutin, carotenoids, vitamins B, K, P, polysaccharides. Contains esculin, which determines the main biological activity of the extract: the ability to strengthen the walls of blood vessels and capillaries, stimulate blood circulation, and improve metabolic processes in skin cells.

Menthol - provides a cooling effect. It has weak local anesthetic properties, stimulates cold receptors of the skin and mucous membranes, is a weak antiseptic, and gives a slight antibacterial effect.

Lemon essential oil helps increase energy metabolism in the skin and stimulates collagen synthesis. Cleanses, refreshes, improves skin condition. It has an antibacterial effect, stimulates the regeneration process of skin cells, smoothes out fine wrinkles.

Indications for use

Contraindications

Individual intolerance to components.

Directions for use and doses

Apply a small amount of gel cream evenly in a thin layer to the problem area 2 times a day and rub in with massage movements until completely absorbed. Before each application, clean the skin with warm water or a warm, damp cloth. Avoid contact with eyes and mucous membranes.

Storage conditions

Store at temperatures from +5 °C to +25 °C in a dry place, protected from light and away from heating devices. Keep out of the reach of children

Best before date

2 years

Vacation conditions

Over the counter

Troxerutin 300 mg 50 pcs. pranapharm capsules

pharmachologic effect

Venotonic and venoprotective agent.

Composition and release form Troxerutin 300 mg 50 pcs. pranapharm capsules

Capsules - 1 capsule:

Active ingredient: troxerutin 300 mg;
Excipients (up to the contents of the capsule weighing 335 mg): macrogol 6000, colloidal silicon dioxide, magnesium stearate, lactose monohydrate;
Excipients for capsule shell: titanium dioxide, gelatin.

Capsules, 300 mg.

10 capsules per blister pack made of polyvinyl chloride film and printed varnished aluminum foil.

1, 2, 3, 4, 5 blister packs along with instructions for use are placed in a cardboard pack.

Description of the dosage form

Hard gelatin capsules, size No. 0, white. Contents: granular powder or a mixture of powder and granules, or a compressed mass taking the form of a capsule, greenish-yellow in color.

Directions for use and doses

Inside, during meals. Capsules should be swallowed whole with plenty of water.

For chronic venous insufficiency and its complications, for the symptomatic treatment of hemorrhoids, at the initial stage, 1 capsule (300 mg) is prescribed 2-3 times a day (600-900 mg), depending on the severity of the symptoms. The effect usually develops within 2 weeks. Treatment is stopped after symptoms and swelling disappear.

In case of recurrence of symptoms, treatment is resumed at the same dose or the dose is reduced - 1 capsule 2 times a day (600 mg).

The achieved effect lasts for at least 4 weeks. The course of treatment averages 3-4 weeks.

For diabetic retinopathy, the drug is used in a dose of 1800-3000 mg, 6-10 capsules (2 times a day, 3-5 capsules). The course of treatment averages 3-4 weeks.

The need for longer treatment is determined after consultation with a doctor and individually.

If there is no improvement during treatment, or symptoms worsen, or new symptoms appear, you should consult your doctor. Use the drug only according to the indications, method of administration and in the doses indicated in the instructions.

Pharmacodynamics

Troxerutin is a derivative of rutin (flavonoid) and has P-vitamin activity; has venotonic, angioprotective, decongestant, antioxidant and anti-inflammatory effects.

Troxerutin blocks hyaluronidase, stabilizes hyaluronic acid in cell membranes and reduces their permeability. It has antioxidant activity, which prevents the oxidation of ascorbic acid, adrenaline and lipids. In addition, it reduces the permeability and fragility of capillaries, prevents damage to the basement membrane of endothelial cells when exposed to various factors.

Reduces inflammation in the vascular wall, limiting platelet adhesion to its surface. Inhibits aggregation and increases the degree of deformation of red blood cells.

For patients with chronic venous insufficiency, use is recommended both in the initial and late stages of the disease. It can be used as one of the components of complex treatment.

Troxerutin reduces swelling and a feeling of heaviness in the legs, reduces the intensity of pain and cramps, and improves tissue trophism.

Troxerutin relieves symptoms associated with hemorrhoids (pain, exudation, itching, bleeding).

Due to its effect on the permeability and resistance of capillary walls, troxerutin helps slow the progression of diabetic retinopathy. The effect of troxerutin on the rheological properties of blood helps to stop the development of retinal vascular microthrombosis.

Pharmacokinetics

Suction

After oral administration, absorption is about 10-15%. The maximum concentration in blood plasma (Cmax) is achieved within 1-9 hours. Within 120 hours, concentrations remain detectable; the decrease in concentration is bioexponential.

Distribution

The connection with blood plasma proteins is 27-29%, and accumulates in the largest quantities in the endothelium. Does not penetrate the blood-brain barrier. It penetrates the placental barrier slightly and is excreted in minimal quantities in breast milk.

Biotransformation

Metabolized mainly through o-glucuronidation in the liver.

Removal

It is excreted mainly through the intestines and to a lesser extent by the kidneys.

Indications for use Troxerutin 300 mg 50 pcs. pranapharm capsules

Chronic venous insufficiency.

Postthrombotic syndrome.

Trophic disorders in varicose veins and trophic ulcers.

As an auxiliary treatment after sclerotherapy of veins and removal of varicose veins.

Hemorrhoids (pain, exudation, itching and bleeding).

As an adjuvant treatment of retinopathy in patients with diabetes mellitus, arterial hypertension and atherosclerosis.

Contraindications

Hypersensitivity to troxerutin or to any other component of the drug.

Lactose intolerance, lactase deficiency, glucose-galactose malabsorption syndrome.

Peptic ulcer of the stomach, duodenum, chronic gastritis in the acute phase.

Pregnancy (1st trimester).

Breastfeeding period.

Children under 18 years of age (experience of use is limited).

Carefully:

Renal failure (with long-term use).

Pregnancy (II and III trimester).

Application of Troxerutin 300 mg 50 pcs. Pranafarm capsules during pregnancy and breastfeeding

Pregnancy

Experimental studies have not shown teratogenicity or fetotoxicity of drugs containing troxerutin, but there is evidence of a possible association between taking troxerutin during pregnancy and abnormalities in the structure of the external ear in children.

The use of TROXERUTIN during the first trimester of pregnancy is contraindicated. The possibility of using the drug during the second and third trimester of pregnancy is determined by the doctor and is possible only if the expected benefit to the mother outweighs the potential risk to the fetus.

If it is necessary to use the drug in the second and third trimesters of pregnancy, you should consult your doctor.

Breastfeeding period

It is excreted in minimal quantities in breast milk.

The use of TROXERUTIN during breastfeeding is contraindicated.

special instructions

There is insufficient experience with the use of troxerutin in children under 18 years of age.

When treating superficial thrombophlebitis or deep vein thrombosis, the use of the drug does not exclude the need to prescribe anti-inflammatory and antithrombotic therapy.

Troxerutin is ineffective for edema caused by concomitant diseases of the liver, kidneys and heart.

When using the drug independently, you should not exceed the maximum duration and recommended doses.

If during the period of use of the drug the severity of the symptoms of the disease does not decrease or the symptoms of the disease become more severe, you should immediately consult a doctor.

Impact on the ability to drive vehicles and operate machinery

Taking the drug does not affect the ability to perform potentially hazardous activities that require increased concentration and speed of psychomotor reactions (driving vehicles, working with moving mechanisms, working as a dispatcher, operator).

Overdose

Symptoms

In case of an overdose, the following symptoms may appear: agitation, nausea, headache, flushing of the face.

Treatment

It is necessary to rinse the stomach and take activated charcoal (within an hour after administration). If necessary, provide symptomatic and supportive treatment.

In case of overdose, consult a doctor immediately.

Side effects Troxerutin 300 mg 50 pcs. pranapharm capsules

The incidence of adverse reactions was determined according to the WHO classification: very often (≥ 1/10); often (≥ 1/100 and

Immune system disorders: very rarely - anaphylactic shock, anaphylactoid reactions, hypersensitivity reactions (for example, skin rash).

Nervous system disorders: very rarely - headache, dizziness.

Vascular disorders: very rarely - hyperemia (“flushes”), ecchymosis.

Gastrointestinal disorders: rarely - nausea, pain and discomfort in the stomach, dyspepsia, flatulence, diarrhea, erosive and ulcerative lesions of the gastrointestinal tract.

Disorders of the skin and subcutaneous tissues: rarely - itching, rash, urticaria.

Other: very rarely - feeling of fatigue.

If you experience the side effects listed in the instructions, or they get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Drug interactions

There are no established drug interactions.