Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Diclofenac is a non-steroidal anti-inflammatory drug. Blocks cyclooxygenase , suppresses the synthesis of prostaglandins - endogenous mediators of inflammation, temperature and pain. Thus, diclofenac reduces pain and inflammation.
Menthol irritates cold receptors. As a result, capillary permeability decreases locally and a feeling of coolness occurs. Menthol also has a local moderate analgesic effect.
A derivative of salicylic acid , methyl salicylate, has a local irritant effect. As a result, substance P from nerve cells. This reduces pain. Methyl salicylate also inhibits prostaglandin , which reduces swelling and tissue infiltration.
Oil obtained from flax seeds has an anti-inflammatory and antioxidant effect, and activates blood circulation at the site of application.
Pharmacokinetics
Gel Fanigan Fast begins to act 2-4 minutes after application to the skin. And after another half hour the effect reaches maximum strength. The disappearance of the main clinical symptoms usually occurs in the first few days after the start of therapy with Fanigan Fast Gel.
When the drug is applied topically, about 5% of the dose used is absorbed, its systemic effect is minimal.
general characteristics
basic physical and chemical properties: homogeneous white gel with a characteristic odor; composition: 1 g of gel contains diclofenac diethylamine 11.6 mg, equivalent to diclofenac sodium 10 mg, menthol 50 mg, methyl salicylate 100 mg, flax oil 30 mg; excipients: propylene glycol, carbomer 940, sodium edetate, polysorbate 80, sodium hydroxide, methyl parahydroxybenzoate, propyl parahydroxybenzoate, purified water.
Release form
Gel for external use.
Pharmacotherapeutic group
Non-steroidal anti-inflammatory drugs for topical use. Diclofenac, combinations.
Pharmacological properties
When applied topically, it has an analgesic, anti-inflammatory and anti-edematous effect. Eliminates pain and inflammation of joints, reduces morning stiffness and swelling of joints, and helps increase range of motion in joints. Pharmacodynamics. Fanigan's action? The fastness of the gel is due to the components that are included in its composition. Diclofenac belongs to the group of non-steroidal anti-inflammatory drugs. Inhibits cyclooxygenase, inhibits the biosynthesis of prostaglandins - endogenous substances that play an important role in the genesis of fever, inflammation and pain. Diclofenac relieves pain and eliminates inflammation. Menthol irritates cold receptors. This is accompanied by a narrowing and decrease in the permeability of capillaries at the site of application, and a feeling of coolness. Menthol has a local distracting and moderate analgesic effect. Methyl salicylate is a derivative of salicylic acid and has a local irritant effect. By irritating skin receptors, methyl salicylate leads to the formation and release into the blood of a large amount of biologically active substances that regulate pain sensitivity. Substance P is released from neurons. Reducing the accumulation of substance P in nerve endings leads to a decrease in pain. In addition, methyl salicylate, which belongs to the group of non-steroidal anti-inflammatory drugs, inhibits the synthesis of prostaglandins due to inhibition of cyclooxygenases, which reduces swelling and infiltration of inflamed tissues. Flax seed oil, the main component of which is alpha-linolenic acid (ethyl ester of an unsaturated fatty acid), has an anti-inflammatory effect, antioxidant properties, and improves blood circulation at the site of application. Fanigan's action? The fast of the gel begins within a few minutes after application to the skin. After 20–30 minutes, the effect of the gel reaches its maximum. The disappearance of the main clinical symptoms is usually observed during the first days from the start of treatment. Pharmacokinetics. Not studied.
Indications for use
Local treatment for: - diseases of the musculoskeletal system of an inflammatory and degenerative nature, which are accompanied by pain and swelling, such as: - rheumatoid arthritis, - ankylosing spondylitis (Bechterew's disease), - rheumatic lesions of soft tissues (tenosynovitis, bursitis, myositis), - acute gouty, infectious, psoriatic and post-traumatic arthritis, - degenerative joint diseases (osteoarthrosis of large and small joints), - osteochondrosis of the spine, - myalgia, neuralgia, sciatica; - injuries (bruises, sprains, muscles and tendons); - pain in muscles and joints caused by heavy physical activity. Directions for use and doses
Depending on the area of the painful area, 2–4 g of gel (a strip of 4–8 cm) is applied in a thin layer to the skin and lightly rubbed in 2–3 times a day. The average daily dose is 10 g of gel, which corresponds to 100 mg of diclofenac sodium. The drug should be applied to intact skin, avoid contact with eyes and mucous membranes. Do not apply the gel to open wounds. The duration of treatment should not exceed 10 days without consulting a doctor. Side effects. Fanigan? Fast gel is well tolerated. When applied topically, a very small amount of the drug (approximately 5%) is absorbed and enters the systemic circulation, which helps reduce the likelihood of side effects that are typical for non-steroidal anti-inflammatory drugs. Rarely, skin irritations are possible at the site of application, such as rashes, swelling and the formation of blisters, papules, scales, redness, as well as dry skin, a burning or tingling sensation, and itching of the skin. If diclofenac is applied to large surfaces of the body and for a long time, it is impossible to exclude the development of systemic side effects, similar to those that occur when taking tablets, suppositories or ampoules that contain diclofenac. In isolated cases, manifestations of a generalized rash, the development of a hypersensitivity reaction in the form of facial swelling (angioedema) and suffocation, as well as photosensitivity may be observed. If any side effects occur, additional examination and adjustment of therapy should be carried out. Contraindications
Hypersensitivity to diclofenac and other components of the drug; damage to the epidermis, open wounds at the site of application; status asthmaticus while taking acetylsalicylic acid; disorder of hematopoiesis of unknown etiology; gastric and duodenal ulcers in the acute stage; last trimester of pregnancy; children under 12 years of age (there is not enough experience on the external use of the drug at this age). Overdose
There is no data on overdose with topical application of Fanigan® Fast Gel. Features of application
For patients who have previously experienced a hypersensitivity reaction to topical use of acetylsalicylic acid, other salicylates and other non-steroidal anti-inflammatory drugs (asthmatic attacks, skin reactions or vasomotor rhinitis), the drug is prescribed with caution, carefully weighing all expected risk factors and benefits. Fanigan® Fast Gel should be used with caution if there is a history of peptic ulcers of the stomach and duodenum, impaired liver/kidney function, impaired blood formation, or polyposis of the nasal mucosa. After applying the gel, you must wash your hands to avoid contact of drug residues with mucous membranes and eyes. During periods of pregnancy and lactation, the gel should not be applied to large areas of the body and used for a long time, since to date there is no data on the harmful effects of the drug on the fetus. Interaction with other drugs
Fanigan® Fast Gel can be used simultaneously with other medications, since systemic interactions with them of the components of this drug have not been identified, including with oral administration of diclofenac sodium. But, with long-term use of Fanigan? Fast gel in large doses, it is necessary to take into account that diclofenac can enhance the effect of anticoagulants, glucocorticosteroids, lithium preparations, and also weaken the effect of furosemide and thiazide diuretics. The drug can increase the concentration of digoxin in the blood plasma, reduce the tolerance of other non-steroidal anti-inflammatory drugs, increasing their ulcerogenic effect on the mucous membrane of the gastrointestinal tract. With the simultaneous local use of several drugs that contain non-steroidal anti-inflammatory drugs, local irritation in the form of urticaria, redness, and peeling may develop. Storage conditions
Store out of reach of children, protected from direct sunlight at a temperature not exceeding 25° C. Do not allow freezing. Best before date
2 years. Vacation conditions
Over the counter.
Attention! The description of the drug on this page is simplified. Before purchasing and using the drug, consult your doctor or pharmacist, and also read the instructions approved by the manufacturer. Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. ATTENTION! This section is provided for informational purposes only and is not a catalog or price list of our company. To obtain information about the availability of drugs, call + 99871 202 0999 Pharmacy Network Helpline 999.
Contraindications
- Allergy to diclofenac , any other components of the drug, aspirin or other non-steroidal anti-inflammatory drugs .
- Urticaria , attacks of bronchial asthma or acute rhinitis caused by taking aspirin or other non-steroidal anti-inflammatory drugs .
- Damage to the skin or wounds in the area where the drug is used.
Side effects
The drug may cause the following adverse reactions::
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Overdose
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Next fact
Due to the low absorption of active substances into the systemic circulation, an overdose is unlikely. If accidentally ingested, systemic adverse reactions may occur. In this case, it is recommended to empty the stomach and consume the adsorbent.
Therapy is symptomatic, using therapeutic measures that are used for treatment with non-steroidal anti-inflammatory drugs.
Contraindications
Contraindications to the use of the drug are as follows::
- Hypersensitivity to diclofenac or other components.
- History of attacks of urticaria, bronchial asthma, acute rhinitis.
- Damage to the epidermis or open wounds at the site of application.
- Third trimester of pregnancy.
Reception during pregnancy and lactation
It is not recommended to use the drug during pregnancy and lactation . In the third trimester, the gel is strictly contraindicated, as it can lead to weakness of labor or premature closure of the ductus arteriosus.
During lactation, the drug can be prescribed for good reasons, if the potential benefits, in the opinion of experts, outweigh the potential risks. Do not apply the gel to the mammary glands and large areas of skin and use it for more than a week.
Video: “The drug Fanigan in tablets”
Instructions for Fanigan Fast Gel
Instructions for use of Fanigan Fast ointment recommends that adults and children over 12 years of age apply 3-4 g of gel to the skin and rub in up to three times a day. The average daily dose is about 10 grams of gel, which is equivalent to 100 mg of diclofenac sodium . The drug should be applied to intact skin, avoid contact with mucous membranes and eyes. The duration of therapy is determined by the attending physician depending on the clinical picture of the disease and the effectiveness of treatment.
The gel is not recommended for use for more than two weeks for injuries and rheumatism or for more than three weeks for arthritis .
Elderly patients do not need to adjust the frequency of administration and dose.
special instructions
Use with caution concomitantly with oral NSAIDs.
The likelihood of developing systemic side effects with topical use of diclofenac is insignificant compared to oral use, but cannot be excluded when using the drug on large areas of the skin for a long time.
Fanigan Fast Gel should not be used with other products containing diclofenac. The drug should be used with caution in case of peptic ulcer of the stomach and duodenum in the acute stage and in the presence of a history of it, impaired liver/kidney function, impaired hematopoiesis, polyposis of the nasal mucosa.
Fanigan Fast Gel is not recommended to be applied to damaged skin areas, preventing contact with inflamed, wounded or infected skin. Contact of the drug with the eyes and mucous membranes should be avoided. The drug should not be swallowed. Fanigan Fast Gel contains propylene glycol, which may cause mild localized skin irritation in some patients.
If any skin rashes appear, treatment should be discontinued. Fanigan Fast Gel should not be used under an airtight occlusive dressing. In case of a sprain, the affected area can be bandaged.
Use during pregnancy and lactation. Clinical experience with use in pregnant women is limited, therefore the use of this drug is not recommended during pregnancy and lactation. Fanigan Fast Gel is contraindicated in the third trimester of pregnancy due to the possibility of developing weakness of labor and/or premature closure of the ductus arteriosus.
If there are compelling reasons for using the drug Fanigan Fast Gel during breastfeeding, when the expected benefit of the drug, in the opinion of the doctor, outweighs the potential risk, the drug should not be applied to the mammary glands or large areas of skin and should not be used for a long time (more than 1 weeks).
Children. Contraindicated in children under 14 years of age. When using the drug in children over 14 years of age for more than 7 days or if the symptoms of the disease intensify, you should consult a doctor.
The ability to influence reaction speed when driving vehicles or other mechanisms. Does not affect.
Interaction
When using Fanigan Fast gel long-term in high doses, it should be taken into account that diclofenac enhances the effects of glucocorticosteroids, anticoagulants lithium preparations and enhances the effects of thiazide diuretics and furosemide .
non-steroidal anti-inflammatory drugs are used together locally, urticaria , hyperemia are likely to occur .
Overdose
Overdose is unlikely due to the low absorption of diclofenac into the systemic circulation when applied topically. in case of accidental ingestion, it should be taken into account that 1 tube of the drug, 100 g each, contains the equivalent of 1 g of diclofenac sodium; in this case, the development of systemic adverse reactions is possible.
If you accidentally swallow the drug, you should immediately empty your stomach and take the adsorbent. Symptomatic treatment is indicated using therapeutic measures used to treat NSAID poisoning.
Analogs
Level 4 ATC code matches:
Voltaren Emulgel
Ultrafastin
Indomethacin
Dicloran
Dicloran Plus
Dolgit
Nise
Ketonal
Ketorol
Febrofeed
Fastum gel
Diclofenac
Finalgel
Bystrumgel
Deep Relief
Butadion
Diklovit
Artrosilene
Olfen
Analogs of Fanigan Fast Gel: Butadion, Voltaren, Diclak, Dicloran, Diclofenac, Dolgit, Nise, Fastum and others.
Reviews
The drug has many good reviews. The drug receives many positive reviews. Buyers note its affordable price in comparison with other means of similar action, while the treatment results are no worse.
The reviews note the rapid action of the drug - it makes itself felt within a few minutes.
Application quickly eliminates pain and swelling, improves motor activity, and allows a person to lead a normal life.
However, experts insist that the drug should not be used for more than 2-3 weeks, and it has a more symptomatic effect.
Therefore, when treating, for example, osteochondrosis, it will relieve symptoms and, possibly, have an effect on the inflammatory process, however, therapy for this disease should be longer and more complex.
Experts confirm that the drug is affordable and effective . It is prescribed for appropriate indications. In some cases, doctors prescribe it for a longer period, but it is necessary to constantly monitor blood counts and the general condition of the body.
If you have used Fanigan fast, please share your feedback, which will help other site visitors.
Video: “Drugs for osteochondrosis: review and comparison”
Price, where to buy
The price of the drug with a dosage of 30 grams in Ukraine is close to 26 hryvnia, in Russia it is approximately equal to 159 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
LuxPharma* special offer
- Fanigan fast gel (Diclofenac Sodium) 100g
1590 RUR order
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Pharmacy24
- Fanigan Fast 30 g gel Kusum Healthker PVT.LTD, India
33 UAH order - Fanigan Fast gel 100g Kusum Healthker PVT.LTD,India
76 UAH order
Note!
The description of the drug Fanigan Fast gel 100g on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.