What is the mechanism of drug action
The ointment has 3 main effects. It promotes tissue healing, affects metabolism and relieves inflammation. After contact with the wound area, the active substance interacts with the main proteins, for example, albumin. The active substance is involved in processes such as carbohydrate and lipid metabolism, the formation of hormones, mediators and porphyrins. "Dexpanthenol" has a regenerative effect not only on tissues, but also on mucous membranes. The drug also helps stabilize cellular metabolism and accelerate cell mitosis. Elimination is very fast.
Dexpanthenol
Dosage form
Ointment for external use
Composition per 100 g:
Active substance
: dexpanthenol – 5.0 g.
Excipients
: petrolatum – 27.0 g, liquid paraffin – 10.0 g, lanolin – 17.0 g, cholesterol – 0.5 g, isopropyl myristate – 3.0 g, methyl parahydroxybenzoate – 0.07 g, propyl parahydroxybenzoate – 0.03 g , water – 37.4 g.
Description
A homogeneous ointment from white with a yellowish tint to light yellow with a specific odor.
Pharmacotherapeutic group
Tissue repair stimulator.
ATX code: D03AX03
Pharmacological properties
Pharmacodynamics
Dexpanthenol is a derivative of pantothenic acid. Pantothenic acid - a water-soluble B vitamin (vitamin B5) - is an integral part of coenzyme A. Stimulates skin regeneration, normalizes cellular metabolism, accelerates mitosis and increases the strength of collagen fibers. An increased need for pantothenic acid is observed when the skin or tissues are damaged, and its deficiency can be compensated for by the local use of dexpanthenol.
Pharmacokinetics
When applied externally, it is quickly absorbed and converted into pantothenic acid and binds to blood plasma proteins (mainly beta-globulin and albumin). The concentration of pantothenic acid in the blood is 0.5-1 mg/l, in the blood plasma - 100 μg/l.
Pantothenic acid is not metabolized in the body and is excreted unchanged by the kidneys.
Indications for use
In case of violation of the integrity of the skin: healing of burns (including sunburn), minor skin damage (abrasions, cuts, cracks, etc.). Prevention and treatment of dry skin, including as a consequence of dermatitis of various origins (manifested by peeling, redness, irritation, feeling of tightness), as well as daily care of areas of the skin exposed to the greatest influence of external factors (face, hands), including due to weathering. For caring for the mammary gland during lactation (cracks and redness of the nipples of the mammary gland), for caring for infants and infants (diaper rash, diaper dermatitis).
Contraindications
Hypersensitivity to dexpanthenol and the components of the drug.
Use during pregnancy and breastfeeding
The drug can be used during pregnancy and breastfeeding. If the drug is used to treat cracked nipples during lactation, it should be washed off before breastfeeding.
Directions for use and doses
Externally. The ointment is applied in a thin layer to the affected area of the skin, lightly rubbing 2-4 times a day. If applied to an infected skin surface, it should be pre-treated with an antiseptic.
For nursing mothers, apply ointment to the infected surface of the nipple after breastfeeding. For infants, apply to the site of infection after changing clothes or water procedures.
The duration of use of the drug and the possibility of a second course of treatment depend on the individual characteristics of the course of the disease and are determined by the achieved effect and tolerability of the drug.
If there is no improvement after treatment or new symptoms appear, you should consult your doctor. Use the drug only according to the method of use and in the doses indicated in the instructions. If necessary, please consult your doctor before using the medicine.
Side effect
Allergic reactions, allergic skin reactions (eg contact dermatitis, allergic dermatitis, itching, redness, eczema, rash, urticaria, skin irritation). If any of the side effects indicated in the instructions worsen, or any other side effects not listed in the instructions are noted, you should immediately inform your doctor.
Overdose
No cases of overdose have been reported.
Interaction with other drugs
Not studied.
special instructions
Avoid contact with eyes or mucous membranes. Do not apply to wet wounds.
During pregnancy and lactation, use on large areas should be avoided.
Read the instructions carefully before you start using the drug. Save the instructions, you may need them again. If you have any questions, consult your doctor. The medicine you are using is intended for you personally and should not be given to others as it may cause harm to them even if they have the same symptoms as you.
The effect of the drug on the ability to drive vehicles and machinery
The drug does not affect the ability to drive or engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Release form
Ointment for external use 5%.
5, 10, 15, 20, 25, 30, 35, 40, 50, 60, 70, 80, 90, 100 g in orange glass jars with a triangular rim and a lid that is tensioned with a sealing element.
5, 10, 15, 20, 25, 30, 35, 40, 50, 60, 70, 80, 90, 100 g in polymer jars complete with lids or in polyethylene terephthalate jars with closures.
20, 25, 30, 35, 40, 50, 60, 70, 80, 100 g in aluminum tubes coated with BF-2 varnish, with caps made of high-density polyethylene.
Each jar and tube, along with instructions for use, is placed in a cardboard pack.
Storage conditions
At a temperature not higher than 25 °C.
Keep out of the reach of children.
Best before date
3 years.
Do not use after the expiration date stated on the packaging.
Vacation conditions
Available without a prescription.
When to use
"Dexpanthenol" is most often used to accelerate healing for minor microtraumas. Can be used on mucous membranes in the presence of erosions. The drug helps fight dry and cracked skin and is indicated for burns and minor abrasions. Sometimes the ointment is prescribed to patients with bullous dermatitis, suppuration and trophic ulcers. It is allowed to be used for the treatment and prevention of bedsores in bedridden patients. The ointment is applied to aseptic wounds for transplantations that do not take root well after operations, but constant monitoring by the attending physician is required.
How to use for pregnant women and children
Use in children is no different from adults.
The ointment is approved for use by pregnant and lactating women. For treatment in the breast area around the areola in women during breastfeeding, Dexpanthenol is recommended in the form of compresses. Before starting feeding, it is necessary to remove the remaining ointment with running water, without using soap, which can dry out the treated area.
"Dexpanthenol" is also necessary for restoring the skin from diaper rash in newborns.
Dexpanthenol E cream (50mg+5mg)/1g 30g No.1
Name
Dexpanthenol E cream dnar.prim. (50mg+5mg) 1g in tubes 30g in pack No. 1
Description
The cream is white or yellowish-white.
Main active ingredient
Dexpanthenol+tocopherol
Release form
cream
Dosage
30g
Pharmacological properties
Pharmacodynamics
Dexpanthenol is provitamin B5. Its action is similar to that of pantothenic acid, but it is better absorbed when applied topically. Pantothenic acid is a constituent of coenzyme A, which, in the form of coenzyme acetylCoA, plays an important role in cellular metabolism. Pantothenic acid plays an important role in the processes of acetylation and oxidation, participates in carbohydrate and fat metabolism and in the synthesis of acetylcholine. It has a pronounced effect on the formation and function of epithelial tissue. The active substance penetrates well into the affected area. Promotes regeneration of skin exposed to harsh meteorological influences. Accelerates the regeneration of damaged skin.
Pharmacokinetics
When applied topically, it is quickly absorbed and converted into pantothenic acid and binds to plasma proteins (mainly beta-globulin and albumin).
Indications for use
Mild skin damage caused by mechanical, chemical, temperature and other factors:
- scratches, abrasions;
- 1st degree sunburn
In children over 1 year of age - for the prevention and treatment of mild diaper dermatitis. In nursing mothers - for the prevention and treatment of cracked nipples of the mammary glands. Protecting the skin from the effects of adverse climatic factors (chapping and frostbite). Prevention and treatment of mild diaper rash in children and adults.
Directions for use and doses
The medicine is intended only for external use in children and adults. The cream is applied subcutaneously to the affected areas of the skin once or several times a day, depending on the need. To prevent and treat cracks and inflammation of the nipples after each feeding, the cream is used in the form of a compress. The duration of treatment depends on the type and course of the disease.
Use during pregnancy and lactation
Use during pregnancy is permissible if the benefits of use outweigh the potential risk to the fetus. The drug can be used during lactation (breastfeeding), but it does not need to be applied during feeding (before feeding, remove the remaining cream with a napkin and wash the nipples with water).
Precautionary measures
For external use only. Do not apply to wet wounds. Avoid getting the cream into your eyes (in case of contact, rinse your eyes with warm water). It is not recommended to apply DEXPANTHENOL E to mucous membranes. Cetostearyl alcohol and diethanolamine contained in DEXPANTHENOL E cream may cause contact dermatitis. Benzyl alcohol may cause irritation to the skin and mucous membranes. If allergic reactions occur, treatment should be discontinued. If the course of the disease worsens or new symptoms appear during treatment with DEXPANTHENOL E cream, it is recommended to consult a doctor.
Interaction with other drugs
There were no drug interactions between DEXPANTHENOL E cream and systemic drugs. There are no data on the interaction of DEXPANTHENOL E cream with other topical agents; therefore, their simultaneous use is not recommended.
Contraindications
Hypersensitivity to the components of the drug.
Compound
1 g of cream contains 50 mg of dexpanthenol and 5 mg of β-tocopheryl acetate as active ingredients. Excipients: soft paraffin, white, liquid paraffin, cetostearyl alcohol, macrogol cetostearyl ether, macrogolglycerol hydroxystearate, stearic acid, diethanolamine, benzyl alcohol, purified water.
Overdose
Overdose with the recommended method of use has not been described.
Side effect
From the immune system, skin and subcutaneous tissue: allergic reactions and allergic skin reactions such as contact dermatitis, allergic dermatitis, itching, redness, eczema, rash, urticaria, skin irritation and ulceration. If any side effect occurs or worsens, whether it is described in this section or not, you should contact your doctor immediately.
Storage conditions
In a place protected from light at a temperature not exceeding 25°C. Keep out of the reach of children.