Diprospan injections: instructions for use, indications, price, doctors' reviews and side effects

The hormonal drug Dirospan is a ready-made medicinal suspension. It can be purchased in ampoules or disposable syringes. The product is a clear solution, sometimes with a yellowish tint. It contains suspended particles that, when shaken, transform the liquid into a stable suspension.

The medicine belongs to glucosteroids. Diprospan injections, the instructions indicate this, include betamethasone. It is the main active ingredient. In the manufacture of the medicine, a complex of auxiliary components is used that enhance the effect of the medicine. A single dose of 1 ml contains 5 mg of betamethosone. The medicine is characterized by anti-inflammatory, antitoxic, antiallergic, antishock, and immunosuppressive effects. In addition, it has a pronounced effect on metabolism.

pharmachologic effect

Glucocorticosteroid. The active ingredient is betamethasone . The mechanism of action is based on inhibition of the release of interleukins 1 and 2, interferon-gamma from macrophages and lymphocytes.

The drug has antiallergic, antishock, anti-inflammatory, immunosuppressive, antitoxic and desensitizing effects. Diprospan does not affect the level of circulating beta-endorphin, but suppresses the release of beta-lipotropin and ACTH from the pituitary gland .

Is Diprospan hormonal or not?

The drug is hormonal.

Diprospan after rhinoplasty

Diprospan is often prescribed after rhinoplasty. Diprospan is a hormonal drug, and patients always have many questions regarding this drug.

The main question is, is it safe? Will a person get better when using it? Will there be any unevenness or depression of the skin above the injection site? Is it possible to do secondary rhinoplasty if you don’t like the result of the primary rhinoplasty, and during the rehabilitation period the doctor administered Diprospan?

What is Diprospan?

First you need to figure out what kind of drug Diprospan is? This is a hormonal drug, the active ingredient of which is betamethasone - a synthetic glucocorticosteroid, an analogue of natural hormones (cortisol, cortisone) produced in the adrenal cortex.

Glucocorticosteroids have a main property - they have a powerful anti-inflammatory and anti-edematous effect. And there are no other substances in the pharmaceutical industry that have a similar anti-edematous effect. Therefore, Diprospan is prescribed to patients after nose surgery.

Another important property of glucocorticosteroids is that they have catabolic activity. Diprospan reduces the formation of granulation and connective tissue, and, therefore, inhibits the process, which can negatively affect the effect of rhinoplasty and lead to the formation of pathological scars.

Injections of Diprospan into the soft tissues of the tip of the nose help prevent severe scarring. If scars have already formed after rhinoplasty, injections of the drug can reduce their severity and eliminate this aesthetic defect as much as possible.

Reasons for using Diprospan after rhinoplasty are:

Reduction of swelling, mainly in the area of the tip of the nose.
Prevention of severe scarring.
Reduction in the size of pathological postoperative scars.

Is Diprospan dangerous?

In short, no. However, there are many myths and questions surrounding hormonal drugs that it is necessary to answer this question in as much detail as possible.

What are the specifics of using the drug Diprospan?

Many patients are concerned that Diprospan is a hormonal drug. Unlike the systemic use of this kind of drugs used to treat hormonal imbalances, diabetes, infertility and other diseases, Diprospan does not affect all organs.

It is applied topically only to a small area of tissue. It penetrates poorly into the bloodstream, so it has no overall effect on the body. Systemic action is possible only with large dosages, but the medicine is immediately stopped after swelling decreases.

Side effects: myths and reality

We found out that Diprospan does not have a systemic effect after rhinoplasty. What does this mean in practice? In practice, this means that many of the side effects that plastic surgery patients fear do not and cannot exist.

For example, some are frightened by the prospect of “getting better on hormones.”

To achieve a similar effect, you need to use drugs with systemic action in high doses and over a long period. After one or two injections of Diprospan into the nasal tissue, weight gain is impossible even in theory.

Decreased immunity is another imaginary threat.

Yes, corticosteroids are used in official medicine as immunosuppressants. With their help, doctors reduce the severity of unwanted immune reactions. Allergists include betamethasone in treatment regimens for bronchial asthma. It is important to understand that in order to suppress immune reactions, it is necessary to inject Diprospan intramuscularly and administer it in doses that provide a systemic effect. Such dosages are not used after nose surgery. Moreover, the drug has a beneficial effect on the functioning of the immune system, reduces the risk of allergic reactions, and works as an anti-shock agent. Thanks to the high concentration of betamethasone disodium phosphate, all regenerative processes are accelerated significantly.

The third group of concerns is associated with the possible formation of dimples or “dents” at the injection site (as a rule, Diprospan injections are made into the tip of the nose or into the skin above it).

Here we must admit that such an effect is possible. Betamethasone has a pronounced catabolic effect, which means that it can provoke atrophy of the soft tissues of the nose. An aesthetic defect in the form of skin unevenness may indeed form above the injection area.

An injection of diprospan into the nose during rhinoplasty is prescribed by the attending physician if it is necessary to quickly eliminate large swelling. It is strictly forbidden to inject yourself, as it is dangerous to health.

Reviews from patients about diprospan after rhinoplasty claim that the patient does not experience any unpleasant sensations when the drug is administered. There is no need to inject painkillers into the swollen tissue before injections. The plastic surgeon injects a small dose of the drug locally into each area of swelling, which speeds up the process of tissue restoration.

Among the main advantages of using modern methods of combating edema are the following:

instant penetration into damaged tissue gives a quick positive effect, helping to neutralize the spread of edema;
swelling disappears several times faster, preventing the formation of unsightly scars at the healing site.

Important. An injection after rhinoplasty dramatically reduces the appearance of new swelling or bruising, stimulates tissue restoration, and has a positive effect on regeneration processes. But if used incorrectly, the drug can lead to retraction of the nasal tissue.

Possible side effects when using diprospan after rhinoplasty

It is necessary to use the drug only in a hospital under the supervision of the attending physician, since negative effects may occur that negatively affect the body. For most patients, Diprospan injections after rhinoplasty are absolutely harmless, but there are a number of side effects that you need to be aware of.

A sudden loss of appetite, accompanied by attacks of nausea, is possible.
If the dosage is incorrect, otheoporosis may occur, since the medicine affects the absorption of calcium.
The appearance of unreasonable anxiety, leading to panic, prolonged depression.
Unmotivated pressure surges.
A decrease in the body's resistance to infectious diseases, which is dangerous during the spread of influenza or ARVI.
Rapid weight gain, which can lead to obesity.
Failure of the menstrual cycle.
Increased excitability, leading to insomnia.

Diprospan after rhinoplasty is prescribed by the attending physician if the swelling lasts a long time and the recovery process is sluggish. The specialist independently regulates the dosage and depth of injections in order to achieve the maximum positive effect while minimizing possible risks.

How is the injection given after rhinoplasty?

According to the method of carrying out the procedure, the effect is reminiscent of mesotherapy. Thanks to the use of very thin needles, the patient does not feel pain.

The depth of penetration is regulated by the doctor, always insignificant. Only swollen areas are treated. A small drop of blood may appear at the injection site. The effect accumulates over 3-5 days. The medicine remains in the problem area for up to 2 months, accelerating tissue healing processes. The suspension, entering the area of edema, does not spread to neighboring tissues, acting strictly on the local area.

Numerous positive reviews on the effect of diprospan after rhinoplasty confirm the effectiveness of the drug in postoperative recovery of the body. When prescribing injections, the attending physician must take into account the general condition, weight, complexity of rhinoplasty, and other factors influencing the dosage and duration of treatment.

Pharmacodynamics and pharmacokinetics

The medication can inhibit the secretion of FSH and TSH. The drug Diprospan stimulates the production of erythropoietins , increases the number of red blood cells, reduces the number of eosinophils and lymphocytes, and increases the excitability of the central nervous system. When the active component interacts with specific cytoplasmic receptors, a complex is formed that is able to penetrate inside the cell, into its nucleus and stimulate the process of mRNA synthesis (it is this that induces the process of formation of lipocortin and other proteins that mediate cellular effects).

Lipocortin suppresses the process of release of arachidonic acid , inhibits phospholipase A2, suppresses the process of synthesis of leukotrienes, prostaglandins and endoperoxides, which are actively involved in inflammatory processes and in the formation of an allergic response. Under the influence of Diprospan, the amount of protein in the blood plasma decreases due to globulins, but at the same time the albumin/globulin ratio increases, the production of albumins in the tissues of the kidneys and liver increases, and protein catabolism in muscle tissue increases.

The effect of the drug Diprospan on lipid metabolism: redistribution of fat (fat deposits are localized mainly in the abdomen, face, shoulder girdle), increased synthesis of triglycerides and higher fatty acids, formation of hypercholesterolemia. The effect of the drug on carbohydrate metabolism: activation of phosphoenolpyruvate carboxylase, increased synthesis of aminotransferases (leads to activation of gluconeogenesis), increased absorption of carbohydrates from the digestive tract, increased activity of glucose-6-phosphatase (increases the flow of glucose into the blood from the liver).

The effect of the drug on water-electrolyte metabolism: stimulation of the excretion of potassium ions, retention of water and sodium ions in the body, “washing out” of calcium ions from the skeletal system, decreased absorption of calcium ions from the digestive tract, increased excretion of calcium ions by the renal system. The anti-inflammatory effect is achieved by inhibiting the release of inflammatory mediators by eosinophils; by reducing the number of mast cells (they are the ones who produce hyaluronic acid), inducing the formation of lipocortin, by stabilizing organelle membranes (lysosomal organelles are of particular importance), stabilizing cell membranes, by reducing capillary permeability.

The antiallergic effect is achieved by suppressing the secretion and synthesis of allergic mediators, inhibiting the process of antibody formation, by changing the body's immune response, reducing the sensitivity of effector cells to allergic mediators, by inhibiting the release of biologically active substances and histamine from mast cells, T-lymphocytes, B -lymphocytes.

For COPD, the drug Diprospan prevents and inhibits the development of swelling of the mucous membranes, slows down the course of inflammatory processes, slows down the deposition of circulating immune complexes in the mucous membranes of the bronchial tree, and reduces the rate of eosinophilic infiltration of the submucosal layer in the epithelia of the bronchial tree. The medication inhibits the process of desquamation and erosion of the mucous membranes. Due to the reduction in production and inhibition of mucus production, its viscosity decreases.

Antitoxic and antishock effects are achieved by increasing blood pressure through vasoconstriction, increasing the level of catecholamines circulating in the blood and restoring the sensitivity of adrenergic receptors to them. The effect is achieved through the activation of liver enzymes, which take part in the metabolism of xenobiotics and endobiotics, by reducing the permeability of vascular walls, and also due to the membrane protective effect.

The immunosuppressive effect is ensured by a decrease in the rate of release of cytokines (interferon gamma, interleukin-1,2) from macrophages and lymphocytes. The drug suppresses the secretion and synthesis of ACTH, and secondarily inhibits the process of synthesis of endogenous glucocorticosteroids. Under the influence of the medication, the likelihood of scar formation decreases due to inhibition of the speed of connective tissue reactions during inflammation. You can buy Diprospan in the form of suspensions and solution for injection.

Overdose of the drug Diprospan, symptoms and treatment

Symptoms An acute overdose of betamethasone is not life-threatening. Administration of GCS for several days in high doses does not lead to undesirable consequences (except for cases of use in very high doses or in case of use for diabetes mellitus, glaucoma, exacerbation of erosive and ulcerative lesions of the gastrointestinal tract, or in patients who are simultaneously receiving therapy with digitalis preparations, indirect anticoagulants or potassium-sparing diuretics). Treatment. Careful monitoring of the patient's condition is necessary. Optimal fluid intake and control of electrolyte levels in blood plasma and urine, primarily the balance of sodium and potassium, are shown. If an imbalance of these ions is detected, appropriate therapy must be carried out.

Indications for use of Diprospan

What is Diprospan medicine for?

Indications for the use of Diprospan injections are as follows; the medication is prescribed for:

shock (toxic, cardiogenic, surgical, burn, traumatic);
for anaphylactoid reactions ;
blood transfusion shock;
allergic reactions;
anaphylactic shock;
asthmatic status;
for severe bronchial asthma ;
with cerebral edema (after radiation therapy, after surgery);
in acute adrenal insufficiency .

Also, indications for use are:

systemic pathology of connective tissue ( rheumatoid arthritis , SLE );
poisoning with cauterizing liquids (prevention of the formation of cicatricial narrowings and reducing the severity of inflammation);
hepatic coma;
acute hepatitis;
thyrotoxic crisis.

Blockades with Diprospan are often placed.

Contraindications for Diprospan

Instructions for use of Diprospan do not recommend prescribing the medication intra-articularly:

with pathological bleeding;
for periarticular infections ;
for septic and infectious lesions of the joint;
with a severe form of periarticular osteoporosis;
for general infectious diseases;
with an intra-articular bone fracture;
after arthroplasty ;
with severe bone destruction;
with a “dry” joint;
with osteoarthritis without signs of synovitis;
with joint instability after arthritis,
with aseptic necrosis of the epiphyses of the bones that form the joint.

For fungal, infectious, parasitic and bacterial infections, for herpes zoster, herpes simplex, tuberculosis (latent or active forms), for strongyloidiasis, amebiasis, measles, chicken pox, systemic mycosis - Diprospan is used with caution.

In severe infectious diseases, the drug can be prescribed only with simultaneous specific therapy.

The drug is not used for diseases of the digestive tract:

diverticulitis;
peptic ulcer of the digestive system;
gastritis;
esophagitis;
intestinal anastomosis;
peptic ulcer;
ulcerative colitis.

Betamethasone is not prescribed in the post-vaccination period, for lymphadenitis after the BCG .

The drug is contraindicated for use:

for arterial hypertension ;
diabetes mellitus;
hypothyroidism;
with a recent myocardial infarction;
with decompensated form of CHF;
for Itsenko-Cushing's disease ;
with thyrotoxicosis;
with nephrourolithiasis ;
severe pathology of the liver and kidneys;
with polio;
obesity;
myasthenia gravis;
systemic osteoporosis;
with hypoalbuminemia;
in acute psychosis ;
glaucoma (closed and open angle forms);
during pregnancy;
during breastfeeding.

betamethasone is also a contraindication for Diprospan .

Use of the drug Diprospan

IM if systemic GCS therapy is necessary; directly into the affected soft tissue or in the form of intra-articular and periarticular injections for arthritis; in the form of intradermal injections for various dermatological diseases; in the form of local injections into the lesion for some foot diseases. The dosage regimen and route of administration are set individually, depending on the indications, severity of the disease and the patient’s response to treatment. If a satisfactory clinical effect does not occur after a certain period of time, treatment with Diprospan should be discontinued and other appropriate therapy initiated. For systemic therapy, the initial dose of Diprospan in most cases is 1–2 ml. The administration is repeated as necessary, depending on the patient’s condition. The drug is injected deep intramuscularly into the gluteal muscle:

in severe conditions requiring the use of emergency measures, the initial dose of the drug can be 2 ml;
for various dermatological diseases, as a rule, 1 ml of Diprospan is sufficient;
for asthma, hay fever, allergic bronchitis and allergic rhinitis, a significant improvement in the condition is achieved within a few hours after intramuscular administration of 1–2 ml of the drug;
for acute and chronic bursitis, the initial dose for intramuscular administration is 1–2 ml of Diprospan, with several repeated injections if necessary.

When administered locally, simultaneous use of a local anesthetic is necessary only in isolated cases. If simultaneous administration of a local anesthetic is desirable, use 1–2% solution of procaine hydrochloride or lidocaine, using solutions of drugs that do not contain methylparaben, propylparaben, phenol and other similar substances. When using an anesthetic in combination with Diprospan, the solution is prepared in this way: first, the required dose of the drug is drawn into a syringe from the bottle, then the required amount of local anesthetic is drawn from the ampoule into the same syringe and shaken for a short time. In case of acute bursitis (subdeltoid, subscapular, ulnar and prepatellar), the introduction of 1-2 ml of Diprospan into the synovial bursa can relieve pain and restore mobility within several hours. Treatment of chronic bursitis is carried out with lower doses of the drug after stopping an acute attack of the disease. In case of acute tenosynovitis, tendonitis and peritendinitis, 1 injection of Diprospan alleviates the patient’s condition; in case of a chronic disease, the injection of the drug should be repeated depending on the reaction. It is necessary to avoid injecting the drug directly into the tendon. Intra-articular administration of Diprospan in a dose of 0.5-2 ml eliminates pain and stiffness of joints in rheumatoid arthritis and osteoarthritis for 2-4 hours after administration. The duration of the therapeutic effect of the drug varies significantly and can be 4 weeks or more. Recommended doses of Diprospan when administered into large joints are 1–2 ml; medium - 0.5–1 ml; in small ones - 0.25–0.5 ml. For some dermatological diseases, intradermal administration of Diprospan directly into the lesion , the dose is 0.2 ml/cm2. The lesion is evenly pricked using a tuberculin syringe and a needle with a diameter of approximately 0.9 mm. The total number of Diprospan injections into all areas should not exceed 1 ml over 1 week. Recommended single doses of Diprospan (with intervals between injections of 1 week) for diseases of the feet: for hard calluses - 0.25–0.5 ml (as a rule, 2 injections are effective); for “spur” - 0.5 ml; for stiffness of the big toe - 0.5 ml; for synovial cyst - from 0.25 to 0.5 ml; for tenosynovitis - 0.5 ml; for acute gouty arthritis - from 0.5 to 1 ml. For administration, it is recommended to use a tuberculin syringe with a needle with a diameter of approximately 1 mm. After achieving a therapeutic effect, the maintenance dose is selected by gradually reducing the initial dose by reducing the concentration of betamethasone in the solution, which is administered at appropriate time intervals. The dose reduction is continued until the minimum effective dose is reached. If a stressful situation (not related to the disease) occurs or threatens to occur, it may be necessary to increase the dose of Diprospan. Discontinuation of the drug after long-term therapy should be carried out by gradually reducing the dose. The patient's condition is monitored for at least a year after the end of long-term therapy or after using Diprospan in high doses.

Side effects of Diprospan

Side effects from the use of the drug Diprospan depend on the ability to comply with the circadian treatment regimen, dosage and duration of use of the medication.

Endocrine system: manifestation of latent diabetes mellitus, “steroid” diabetes mellitus, delayed sexual development in children, Itsenko-Cushing syndrome (myasthenia gravis, amenorrhea, dysmenorrhea , stretch marks, hirsutism , pituitary-type obesity, moon-shaped face, increased blood pressure).

Digestive tract: loss of appetite, “steroid” ulcer of the gastrointestinal system, pancreatitis, vomiting, nausea, flatulence, hiccups , increased levels of liver enzymes.

Cardiovascular system: formation of thrombosis, hypercoagulation , increased severity of CHF, bradycardia, arrhythmia.

Nervous system: convulsions, headaches, pseudotumor of the cerebellum, manic-depressive psychosis , euphoria , spatial disorientation , delirium, vertigo, dizziness, insomnia, anxiety , nervousness, increased intracranial pressure, paranoia , depression.

Description of the side effects of Diprospan on the sensory organs: posterior subcapsular cataract, sudden loss of vision, exophthalmos , trophic changes in the cornea, increased intraocular pressure.

Metabolism: increased sweating, increased protein breakdown, negative nitrogen balance, increased body weight, hypocalcemia, increased excretion of calcium ions from the body.

Musculoskeletal system: osteoporosis, atrophy and decrease in muscle mass, “steroid” myopathy , rupture of muscle tendons, slowing down the processes of ossification and growth of the skeletal system in children as a result of premature closure of the epiphyseal growth zones.

Skin: tendency to develop candidiasis and pyoderma, steroid acne, pigmentation disorders, thinning of the skin, formation of ecchymoses and petechiae, slow wound healing.

It is possible to form an allergic response, leukocyturia .

With intravenous administration, convulsions, “flushes” of blood flow to the face, and arrhythmias are possible.

Side effects

Side effects when using the drug Diprospan occur when contraindications and the doctor-recommended regimen of use are violated. In this case, negative reactions can occur from various systems of the human body.

The most common side effects that occur are:

Increased blood pressure.
Arrhythmia.
Headache.
Increased sweating.
Insomnia.
Muscle weakness.
Deterioration of the condition of the skin.
Depression.
Nervousness.

But also when taking the drug, more serious side reactions may occur that pose a threat to health. They are all given in the instructions for use of the drug. If they occur, the use of diprospan should be abandoned.

Diprospan injections, instructions for use

betamethasone dosage regimen and route of administration are selected depending on the nature and severity of the underlying disease.

According to the instructions for use of Diprospan, the infusion solution is diluted in a 0.9% sodium chloride solution or in a dextrose solution before administration. Only freshly prepared solution can be administered. Diprospan injections are given deep intramuscularly at a dose of 4-8 mg for severe pathology.

Periarticular and intraarticular injections of the drug are carried out into very large joints at a dose of 4-8 mg. An injection into the joint directly allows for a more effective effect on the inflammatory process in it. Injections are also given into the knee, but it is better to entrust such injections to doctors, as this is a complex process.

For skin diseases, the drug is administered inside the wound or intradermally at a dose of 0.2 ml/square centimeter.

For bursitis, local infiltration is carried out: 1-2 mg. If necessary, the drug can be administered subconjunctivally at a dose of 2 mg.

When using the medication, it is very important to consider contraindications.

The product is not available in the form of ointments or tablets.

How many times can you inject and how often?

It is better to consult your doctor about this, who will select the dose necessary for you. Uncontrolled use of the drug negatively affects the condition of the body.

Pharmacological properties of the drug Diprospan

Pharmacodynamics. The drug Diprospan is a combination of soluble and poorly soluble betamethasone esters for intramuscular, intra-articular, periarticular, intrasynovial and intradermal administration, as well as for administration directly into the lesion. Diprospan has high GCS activity and insignificant mineralocorticoid activity. The small size of betamethasone dipropionate crystals allows the use of small diameter needles (up to 0.9 mm) for intradermal injections and injection directly into the lesion. Pharmacokinetics. Betamethasone sodium phosphate is a highly soluble component that is rapidly absorbed from the injection site, which ensures a rapid onset of therapeutic action. Betamethasone dipropionate is a poorly soluble component that is slowly absorbed from the depot created at the injection site and provides a long-lasting effect of the drug.

Interaction

Diprospan reduces the effectiveness of anticoagulants , insulin, antihypertensive drugs, and oral hypoglycemic medications. The drug weakens the activity of vaccines and the effect of diuretics .

The use of barbiturates, phenytoin, and Rifampicin weakens the effect of the drug. The risk of side effects increases when treated with antipsychotics, estrogens, androgens, NSAIDs, immunosuppressants, ritodrine, digitalis glycosides, nitrates, tricyclic antidepressants.

Diprospan increases the severity of the hepatotoxic effects of paracetamol. Carbonic anhydrase inhibitors and Amphotericin B increase the risk of osteoporosis. The drug slows down the metabolism of Cyclosporine and increases its toxicity, enhances the metabolism of mexiletine, isoniazid, and increases the concentration of folic acid. The medication reduces the effectiveness of somatotropin .

Interactions of the drug Diprospan

The simultaneous administration of phenobarbital, rifampicin, phenytoin or ephedrine may increase the metabolism of the drug, thereby reducing its therapeutic effectiveness. With the combined use of GCS and estrogens, dose adjustment of the drug may be required (due to the possibility of overdose). The simultaneous use of Diprospan with diuretics, which promotes the excretion of potassium, increases the likelihood of developing hypokalemia. The combined use of GCS and cardiac glycosides increases the risk of arrhythmia or digitalis intoxication (due to hypokalemia). Diprospan may enhance potassium excretion caused by amphotericin-B. Concomitant use of Diprospan and indirect anticoagulants may lead to changes in blood clotting, which may require dose adjustment. With the combined use of GCS with NSAIDs or ethanol, it is possible to increase the incidence or severity of erosive and ulcerative lesions of the gastrointestinal tract. With simultaneous use, GCS can reduce the concentration of salicylates in the blood plasma. The combined administration of GCS and somatropin may slow down the absorption of the latter.

special instructions

Diprospan can be mixed with solutions of local anesthetics in equal volumes. It is unacceptable to use the medication in the treatment of hyaline membrane disease in newborns.

The drug should not be injected into the intervertebral spaces, into infected areas and unstable joints. Before starting treatment, it is necessary to conduct an examination: a general blood test, blood glucose levels, electrolytes.

For concomitant tuberculosis, sepsis, and intercurrent infections, antibiotics are administered simultaneously. Reviews of the drug indicate the high effectiveness of the drug if all recommendations are followed. It is important to consider that in patients with hypothyroidism, the clearance of glucocorticosteroids is reduced; in thyrotoxicosis, the opposite effect is recorded.

Special instructions for the use of the drug Diprospan

Diprospan suspension is not intended for intravenous or subcutaneous administration. Strict adherence to asepsis rules when using Diprospan is mandatory. It should be borne in mind that any administration of the drug (into soft tissue, into the lesion, intra-articularly, etc.) can lead to a systemic effect with simultaneous pronounced local action. In case of thrombocytopenic purpura, intramuscular administration of Diprospan should be carried out with great caution. IM injections of GCS must be carried out into a large muscle mass to prevent local tissue atrophy. Intra-articular injections should only be performed by medical personnel. An analysis of the intra-articular fluid should be performed to exclude the infectious nature of the process. Do not administer the drug if there is an intra-articular infection. A noticeable increase in pain, swelling, increased temperature of the tissues surrounding the joint and further limitation of its mobility indicate infectious arthritis. Once the diagnosis is confirmed, antibacterial therapy must be prescribed. GCS should not be injected into an unstable joint, infected areas or intervertebral discs. Repeated injections into a joint for osteoarthritis may increase the risk of joint destruction. After successful intra-articular therapy, the patient should avoid overloading the joint. Use Diprospan with caution in patients with hypothyroidism or cirrhosis of the liver, eye diseases caused by the herpes virus (due to the possibility of corneal perforation); with nonspecific ulcerative colitis, with the threat of intestinal perforation and abscess formation, as well as with diverticulitis, fresh intestinal anastomoses, peptic ulcers of the stomach and duodenum, renal failure, hypertension (arterial hypertension), osteoporosis, myasthenia gravis. During the use of Diprospan, mental disorders are possible (especially in patients with emotional instability or a tendency to psychosis). When treating Diprospan in patients with diabetes mellitus, adjustment of hypoglycemic agents may be required. Patients receiving corticosteroids should not be vaccinated against smallpox. Other immunizations should not be performed in patients receiving GCS (especially in high doses), given the risk of neurological complications and low immune response (lack of antibody formation). When carrying out replacement therapy (for example, in case of primary adrenal insufficiency), immunization is allowed. Patients who receive Diprospan in doses that can have an immunosuppressive effect should avoid contact with patients with chickenpox and measles (especially important when prescribing the drug to children). When using the drug, it should be taken into account that GCS can mask the symptoms of infectious diseases, as well as reduce the nonspecific resistance of the body. Prescription of Diprospan for active tuberculosis is possible only in cases of progressive or disseminated tuberculosis in combination with adequate anti-tuberculosis therapy. Patients with latent tuberculosis or a positive reaction to tuberculin should first consider the issue of prescribing preventive anti-tuberculosis therapy. Long-term use of GCS can lead to the development of cataracts (especially in children), glaucoma with possible damage to the optic nerve, and also cause secondary eye infections (fungal or viral). It is necessary to periodically conduct an ophthalmological examination of such patients, especially patients who have been receiving Diprospan for 6 months. If blood pressure increases, fluid and sodium chloride retention in tissues and increased excretion of potassium from the body (which can be manifested by peripheral edema, cardiac arrhythmias), a diet with limited salt and additional intake of drugs containing potassium is recommended. One should remember about the possibility of developing secondary adrenal insufficiency for several months after the end of therapy. If a stressful situation occurs or threatens to occur during this period, treatment with Diprospan should be resumed. Acetylsalicylic acid should be taken with caution in combination with Diprospan in case of hypoprothrombinemia due to the risk of bleeding. With the use of corticosteroids, changes in sperm motility and number are possible. Children undergoing Diprospan therapy (especially long-term therapy) should be under medical supervision due to possible growth retardation and the development of secondary adrenal insufficiency. Use during pregnancy and lactation. Due to the lack of data from controlled studies on the safety of Diprospan in pregnant women, prescribing this drug during pregnancy requires an assessment of the expected benefit from the use of the drug and the potential threat to the mother and fetus. Children born to mothers who were administered corticosteroids in therapeutic doses during pregnancy should be under medical supervision for early detection of signs of adrenal insufficiency. If it is necessary to prescribe Diprospan during breastfeeding, the issue of stopping breastfeeding should be decided, taking into account the importance of therapy for the mother and the possibility of side effects in the infant.

Diprospan's analogs

Level 4 ATC code matches:
Prednisolone

Polcortolon

Dexamethasone

Cortef

Dexazone

Metipred

Cortisone

Flosteron

Depo-Medrol

Medrol

Solu-Medrol

Kenalog

Analogues in injections are:

Betaspan Depot
Depos
Flosteron

Which is better: Kenalog or Diprospan?

Both drugs belong to the same pharmaceutical group of glucocorticosteroid drugs. However, based on research, Diprospan is considered a more effective remedy than Kenalog, while the price of the former is slightly higher.

Reviews about Diprospan

Good reviews about Diprospan injections are very common. The drug is mentioned as a powerful anti-inflammatory and antiallergic agent that quickly relieves all unpleasant symptoms.

The medicine Diprospan copes with psoriasis quickly and efficiently, everyone has a generally good opinion about it. The medication also helps with eczema, the use of the drug has positive reviews for arthrosis. However, although the medicine is quite effective, it sometimes has side effects, such as weight gain and shortness of breath.

Diprospan for allergies, reviews from doctors

This remedy should be used only as prescribed by a doctor, and should not be abused under any circumstances. The medication stops an allergic attack, however, the use of the drug also has a poisonous effect on the body.

Diprospan price, where to buy

The price of 1 ampoule of Diprospan is about 400 rubles. You can buy the drug in Moscow for about 370 rubles.
The price of Diprospan injections in Ukraine is 1400-1600 UAH for 5 ampoules of 1 ml.
How much does an allergy shot cost, for example, in Kharkov? Approximately - 300 UAH. In Odessa - 330 UAH.
Tablets of this drug are not sold.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine
Online pharmacies in KazakhstanKazakhstan

LuxPharma* special offer

Diprospan amp.
No. 1 2090 rub. order

ZdravCity

Diprospan susp. for injection 2mg+5mg/ml 1mlSchering-Plough Labo NV
418 RUR order

Pharmacy Dialogue

Diprospan ampoules 2mg+5mg/ml 1ml No. 1Shering-Plough
RUB 421 order

Pharmacy24

Diprospan 1 ml No. 5 solution Schering-Plough Labo N.V./Schering-Plough, Belgium/France
1420 UAH.order
Diprospan 1 ml No. 1 powder SENEXI HSC-EROUVILLE SAINT-CLAIR, France
297 UAH order

PaniPharmacy

Diprospan ampoule Diprospan injection suspension ampoules 1 ml No. 5 Belgium, Schering-Plough Labo
1538 UAH. order
Diprospan syringe Diprospan injection suspension syringe 1 ml with 2 needles No. 1 Belgium, Schering-Plough Labo
330 UAH. order