What is chondroitin for?
Chondroitin is a substance that is part of cartilage tissue, ligaments and bones, an important component of the joint, on which its condition and normal functioning depend. This is not just a building material: chondroitin retains moisture, participates in metabolic processes, and stimulates the production of synovial fluid. Chondroitin affects the functions of cartilage tissue cells - chondrocytes. While the body is young, chondrocytes produce a sufficient amount of collagen and other structural elements of cartilage, but with age, cell activity decreases. Chondroitin deficiency primarily affects the condition of the cartilage: destruction processes begin in it, strength and elasticity decrease, it loses moisture and becomes thinner.
The amount of synovial fluid, which allows the articular surfaces to slide relative to each other, decreases—as a result, the range of motion in the joint is limited. The consequence of these processes is usually inflammation - arthrosis and arthritis develop, accompanied by pain. For people in this situation, it is possible to compensate for chondroitin deficiency only with the help of external sources - food and medications.
Chondrosamine capsules 200mg/250mg No. 10x6
Name
Chondrosamine caps. 200 mg/250 mg in container pack No. 10x6
Description
Hard gelatin capsules of cylindrical shape with hemispherical ends with a white body and an orange cap.
Main active ingredient
Release form
Hard gelatin capsules of cylindrical shape with hemispherical ends, 10 capsules in a blister pack of 5 blister packs along with an insert in a pack.
Dosage
200mg/250m
Indications for use
Directions for use and doses
Adults and children over 18 years of age take orally with a small amount of water, 2 capsules 3 times a day. The optimal dosage regimen is determined by the doctor. Duration of treatment is 1.5-3 months. A stable therapeutic effect is achieved when taken for at least 6 months. Elderly patients Elderly patients do not require dose changes. There are no dosing recommendations for patients with impaired renal and/or hepatic function, as no studies have been conducted in such patients. Children and adolescents Glucosamine-containing medications are not recommended for use by children and adolescents under 18 years of age, as there is no data on the safety and effectiveness of use.
Use during pregnancy and lactation
Due to the fact that there are no clinical data on the effectiveness and safety of the drug during pregnancy and lactation, the drug should not be used during this period.
Precautionary measures
Before use, you should consult your doctor to rule out joint diseases for which other treatment methods are prescribed. In patients with impaired glucose tolerance, monitoring of blood glucose levels is necessary and, if necessary, it is recommended to determine the need for insulin before starting treatment and periodically during treatment. In patients with a known risk factor for cardiovascular disease, it is recommended to monitor blood lipid levels, as hypercholesterolemia has been observed in some cases in patients receiving glucosamine. Exacerbation of asthma symptoms following administration of glucosamine has been reported (symptoms resolved shortly after discontinuation of glucosamine administration). Patients with asthma should be aware of the possible worsening of symptoms. No studies have been conducted in patients suffering from liver or kidney failure. The toxicological and pharmacological profile of the product does not imply any restrictions for the above patients. However, the use of the drug in patients suffering from renal (acute kidney) or hepatic (severe liver) failure should be carried out under medical supervision. Use the drug with caution in case of bronchial asthma and diabetes mellitus. When using the drug in patients with impaired glucose tolerance, medical supervision is necessary. The drug contains lactose. It should not be taken by patients with rare hereditary forms of galactose intolerance, Lapp lactose deficiency or glucose-galactose malabsorption.
Interaction with other drugs
Compatible with non-steroidal anti-inflammatory drugs, paracetamol and glucocorticosteroids. An increase in thrombosis time has been reported with coumarin anticoagulants (eg, warfarin and acetocoumarol). Therefore, in patients receiving coumarin anticoagulants, it is necessary to carefully monitor the initiation and termination of glucosamine therapy. Concurrent treatment with glucosamine may increase the absorption and serum concentrations of tetracycline, but the clinical significance of this interaction is unlikely.
Contraindications
Increased individual sensitivity to any of the components of the drug (allergic reactions), phenylketonuria, severe renal dysfunction, children under 18 years of age. Contraindicated during pregnancy and breastfeeding.
Compound
One capsule contains chondroitin sulfate - 200 mg; glucosamine hydrochloride - 250 mg. Excipients: magnesium stearate, lactose. Composition of the capsule shell: gelatin, glycerin, purified water, titanium dioxide E-171, sodium lauryl sulfate, dye: sunset yellow E - 110.
Overdose
To date, no cases of overdose have been reported. In case of overdose, treatment should be symptomatic, aimed at restoring water and electrolyte balance.
Side effect
The frequency of adverse reactions listed below was determined using the following notation: very common (≥ 1/10), common (≥ 1/100 -
Storage conditions
Store in a place protected from moisture and light at a temperature of 15 ° C to 25 ° C. Store out of the reach of children.
Buy Chondrosamine caps. 200 mg/250 mg in container pack No. 10x6 in the pharmacy
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Instructions for use for Chondrosamine caps. 200 mg/250 mg in container pack No. 10x6
The role of chondroitin in the human body
Chondroitin performs several important functions in the human body:
- stimulates the formation of glycosaminoglycans - the main building material of connective tissue, slowing down the destruction of cartilage and promoting its restoration;
- activates the formation of hyaluronic acid, which retains water in the tissues - this is important for maintaining the elasticity necessary for full shock absorption of the joint;
- interacts with all other components of cartilage, uniting and structuring them, providing the necessary strength;
- forms small water cavities in the cartilage, increasing shock absorption;
- stimulates the production of intra-articular fluid necessary to nourish cartilage tissue and smooth movement of articular surfaces relative to each other;
- makes synovial fluid more fluid, maintaining its natural viscosity;
- reduces pain in joint diseases and increases mobility in them, including by increasing the amount and fluidity of intra-articular fluid;
- prevents the growth of blood vessels into the cartilage;
- suppresses the formation of reactive oxygen species, which accumulate in large quantities during joint aging;
- blocks enzymes that destroy connective tissue;
- suppresses lipid synthesis, thereby preventing the development of atherosclerosis in the walls of blood vessels.
Properties, benefits and role for the human body
Speaking about why glucosamine chondroitin is taken, it is worth turning to the research of scientists. With long-term therapy with drugs that include this compound, pain relief in gonarthrosis in elderly patients is noted. Their quality of life improves as their joints become more functional. The need for non-steroidal anti-inflammatory drugs in this case is reduced (). The properties of glucosamine chondroitin allow the drugs they contain to perform the following functions:
- ensuring the regeneration of failed and damaged tissues;
- support of the process of cellular nutrition;
- prevention of the formation of age spots;
- fight against inflammatory processes in the gastrointestinal tract;
- preservation of tissue structure at the molecular level;
- preventing the appearance of vascular plaques.
Observations by scientists have led to the conclusion that glucosamine chondroitin is effective as a remedy against osteoarthritis. Its mechanism of action is based on triggering the active production of proteoglycans that have a healthy structure. The benefit of glucosamine chondroitin is that it prevents the destruction of cartilage tissue by inhibiting the activity of matrix metalloproteinase. This compound also helps prevent the spread of inflammatory processes ().
How does taking chondroitin affect joints?
Once in the body, chondroitin is absorbed in the intestines and enters the connective tissue through the bloodstream, where it is used in the same way as its natural counterpart. Due to the similar structure of the substance, the body does not see the difference between internal and external chondroitin, so it actively uses chondroitin taken orally. In joints, chondroitin is “embedded” in cartilage tissue, where it stimulates metabolic processes and the formation of synovial fluid. First, it slows down and stops the destruction of cartilage, then gradually reverses the process, starting restoration. But this is only possible with a continuous and long-term intake of chondroitin into the body, therefore drugs containing it (chondroprotectors) are prescribed in long courses.
Indications for use and instructions for use
According to the instructions for use, glucosamine chondroitin is prescribed in case of diagnosis of osteoarthritis, tendinitis, osteoarthritis and discosis. It is recommended to use drugs with this compound for people prone to injuries, such as dislocations and fractures. Glucosamine chondroitin should be used by people who engage in weightlifting, powerlifting or bodybuilding. Their body is subject to great physical stress, after which it needs help in recovery.
Contraindications and side effects
Do not take the drug if you are hypersensitive, or if you are pregnant or breastfeeding.
Contraindications to the use of glucosamine chondroitin are also:
- minor age;
- blood clotting disorder;
- diagnosing diabetes mellitus;
- presence of asthma or hypotension;
- disruption of vascular function, including thrombus formation.
When talking about whether glucosamine chondroitin is effective, it is worth taking into account the cumulative effect of the drugs. In order for the therapy to bring results, you need to take the drug for at least 6 months. Thorough research helped determine how safe long-term use of the drugs is. It is noted that effective relief of pain and restoration of joint functionality is observed both while taking the drugs without breaks, and when they are used in courses of 3 months with breaks of the same duration. Side effects of glucosamine chondroitin have been observed in isolated cases. These include abdominal pain after discontinuation of use and a papular rash during use (). In some cases, drugs can cause nausea, vomiting and diarrhea.
How to drink glucosamine chondroitin: norm per day, dosage
Glucosamine chondroitin is a drug with a cumulative effect, which is why the duration of its use can be up to 12 months, depending on the clinical picture. Athletes are recommended to drink 1500 mg of the drug in 2 or 3 doses. The maximum daily dose of glucosamine and chondroitin for humans is 2000 mg. The drug is started to be taken in a small amount equal to 400 mg, increasing the dosage according to the dosage regimen. It is drunk during or after meals, since the effect of the active substance slows down on an empty stomach.