Mexicor and Mexidol are domestic drugs that are prescribed for the correction and prevention of cardiovascular and neurological diseases, as well as to maintain muscle tone and vitality of the body. Doctors call these agents antioxidants.
Mexicor and Mexidol are prescribed for the correction and prevention of cardiovascular and neurological diseases.
Indications for use
Mexidol belongs to the group of other drugs for the treatment of diseases of the nervous system. Mexicor - to the group of medications for the treatment of heart pathologies. Both medications neutralize decay products and toxins, prevent aging of the body, and improve endurance. The drug is prescribed to improve health in the elderly, patients who have had a stroke, and people with brain pathologies.
The drug is prescribed for ethanol poisoning, clinical treatment of alcoholics, and elimination of withdrawal symptoms.
The active substance in both drugs is ethylmethylhydroxypyridine succinate. Medicines are sold in the form of injections for intramuscular or intravenous administration, in the form of capsules (Mexidol) and tablets (Mexidol).
Diseases and conditions for which medications are prescribed (according to ICD-10):
- anxiety disorder;
- withdrawal syndrome;
- chronic alcoholism;
- neuroses;
- disorders of the autonomic nervous system;
- atherosclerosis;
- acute pancreatitis and peritonitis;
- encephalopathy, unspecified;
- intoxication with antipsychotic and neuroleptic drugs.
Mexidol belongs to the group of other drugs for the treatment of diseases of the nervous system.
And yet there are some differences in indications for use. Mexidol has a wider scope of application and includes:
- physical and mental fatigue;
- somatoform disorders;
- state of shock and stress;
- general weakness and malaise, fatigue;
- circulatory problems in the brain;
- recovery after neurosurgery;
- recovery from head injuries;
- vegetative-vascular dystonia;
- heart attack;
- glaucoma;
- inflammation and necrosis of the gastrointestinal tract and abdominal cavity.
Mexicor is prescribed for stroke, ischemia, encephalopathy, heart attack, and cerebral vascular pathologies.
Composition, properties and mechanism of action
Both medications contain one main active ingredient – ethylmethylhydroxypyridine succinate. The most important way Mexicor differs from Mexidol is the amount of active ingredient. Mexicor contains 100 mg, and Mexidol contains 125 mg. Medicines also differ in the list of excipients, due to which the indications for use partially differ.
The effects of the drugs are very similar. They are antioxidants and actively reduce the number of free radicals in the body, providing:
- improvement of myocardial function;
- normalization of blood circulation in the brain;
- reducing the likelihood of developing a stroke.
They are prescribed in combination with other drugs to stabilize neurotic conditions of varying degrees. The drugs help improve memory and develop cognitive abilities. Often prescribed to older people, especially after strokes, for faster recovery, both physical and mental, to reduce the risk of brain disorders.
Both drugs are also used in the treatment of people who abuse alcohol. They are prescribed for alcohol poisoning accompanied by neurological or neurotoxic symptoms.
It is important to consider the calming effect of both drugs on the nervous system when prescribing sleeping pills. They are prohibited for people whose profession involves activities that require increased concentration.
Mexico's effects on the body
The drugs are similar in their mechanism of action. Research has revealed that both of them have anticonvulsant, neuroprotective and anti-inflammatory properties. The antioxidant properties of ethylmethylhydroxypyridine succinate are associated with the activation of the enzyme superoxide dismutase.
Ethylmethylhydroxypyridine succinate activates cellular glycolysis and the mitochondrial respiratory chain, due to which the body stores energy at the cellular level. This important property is necessary for ischemia, heart attacks, when cellular hypoxia develops.
How do the drugs differ?
Despite the slight difference in names, the drugs differ from each other in the composition of the auxiliary components and the proportion of the main substance, in the form of release and dosage. Mexicor is available in ampoules of 2 ml, Mexidol - 2 ml and 5 ml. Mexicora capsules are available in blisters of 10 pieces, Mexidol tablets are available in a jar of 450 or 900 tablets.
The drug Mexicor is available in ampoules of 2 ml.
Characteristics of active ingredients
The active substance has anxiolytic, antiamnestic, antihypoxic, and antioxidant effects. The product increases the body's resistance to the influence of harmful factors, makes it resistant to pathologies that disrupt oxygen circulation, and reduces the severity of intoxication due to alcohol poisoning.
The capsules contain:
- main substance (0.1 mg);
- starch;
- succinic acid;
- lactose;
- Magnesium stearate.
Mexicora injections include:
- main substance (100 mg per 1 ml);
- water;
- trilon B.
Mexidol tablets contain:
- active substance (125 mg);
- magnesium stearate;
- lactose;
- cellulose gum.
Composition of Mexidol injections:
- active substance (50 mg per 1 ml);
- sodium metabisulfate;
- water.
From the analysis of the compositions it is clear that Mexicor in injections is more powerful than Mexidol. But Mexidol tablets are stronger than Mexicor capsules. As for the difference in additional elements, the choice depends on the specifics of the disease and the individual reactions of the patient.
Which is better - Mexicor or Mexidol
Both drugs have the same effect. In addition to neutralizing toxins, they:
- improve heart function;
- stabilize brain function;
- restore blood circulation;
- reduce the risk of stroke and heart attack;
- suppress symptoms of neurosis (anxiety, fear);
- improve memory, attention and other cognitive functions;
- block muscle cramps;
- improve blood flow and oxygen circulation;
- protect the body from stress;
- stabilize the functioning of the psyche.
Both drugs improve learning ability, prevent aging, and stabilize metabolic processes in the body. There is no better or worse among them. They are both effective in their field.
General information about drugs
Both medications are classified as angioprotective agents and have the same active ingredient. It should be noted that Mexicor is a synonym for Mexidol, that is, they have different names, but the properties and mechanism of action are the same. Mexidol appeared on the market much earlier than Mexicor. In addition, they have different companies - (Russian Federation) and Lekhim Kharkov (Ukraine).
The drugs differ in the form of release:
Mexicor is produced in powder for injection and in tablets. One plate contains 10 tablets.- Mexidol - in powder for injection, in the form of a ready-made solution for injection and in tablets. There are also 10 pieces in one plate. For inpatient units, both medications are supplied in glass vials.
The price of the drugs is different, which is also the difference between Mexicor and Mexidol. Depending on the number of tablets in the package, the price for the first medicine ranges from 130 to 350 rubles. The cost of the second drug is 300-500 rubles.
Directions for use and dosage
Both the choice of medicine and the treatment regimen depend on the individual case. The doctor studies the medical history and individual characteristics of the client. Then he decides to prescribe the medicine. Later in the course of therapy, the doctor may reduce or increase the dosage, replace one drug with another, or withdraw the drug from use.
The average dosage is as follows (depending on the form of release and type of medicine):
- 3 capsules per day;
- 1-2 tablets per day.
The dosage of injections is prescribed individually. They are administered through a dropper (60 drops per minute) or as a stream for 5-7 minutes. Start with a dosage of 0.05-0.1 g (1-3 times a day), gradually increase. The total daily dose should not exceed 0.8 g.
The duration of therapy depends on the disease, characteristics and general condition of the person.
Examples of treatment regimens from the official instructions (injection form):
- Senile dementia and atherosclerosis: intramuscularly, 0.1-0.3 g per day.
- Intoxication with neuroleptics: intravenously, 0.3-0.5 g per day.
- For inflammation and suppuration in the abdominal area: a single dose of 200 mg 3 times a day. In mild cases of the disease, intramuscular administration is permissible; in severe cases, droppers are prescribed. The course of therapy is 4-10 days.
It is unacceptable to self-medicate. To determine the exact regimen, it is recommended to consult a doctor.
Comparison of the safety of Mexidol and Mexicor
The safety of a drug includes many factors.
At the same time, it is higher for Mexidol than for Mexicor. It is important where the drug is metabolized: drugs are excreted from the body either unchanged or in the form of products of their biochemical transformations. Metabolism occurs spontaneously, but most often involves major organs such as the liver, kidneys, lungs, skin, brain and others. When assessing the metabolism of Mexidol, as well as Mexicor, we look at which organ is the metabolizing organ and how critical the effect on it is.
The risk-benefit ratio is when the prescription of a drug is undesirable, but justified under certain conditions and circumstances, with the obligatory observance of caution in use. At the same time, Mexidol has fewer risks when used than Mexicor.
Also, when calculating safety, it is taken into account whether only allergic reactions occur or possible dysfunction of the main organs. In other matters, as well as the reversibility of the consequences of using Mexidol and Mexicor.
special instructions
The drug is not suitable for people whose work requires high concentration and increased concentration. Patients with hypotension, hypertension and cardiac crisis should take the drug with caution.
Pregnancy and lactation
It is prohibited to take medications during pregnancy and breastfeeding.
Childhood
Mexidol is prohibited for the treatment and prevention of diseases in children under 12 years of age, Mexicor - up to 18 years of age.
Elderly age
Taking medications is indicated for the treatment of senile diseases, but special care must be taken in choosing the form of the drug and dosage.
Interaction with other tools
Both drugs are combined with almost all medications that are prescribed for the treatment of somatic disorders. However, Mexidol enhances the effects of antidepressants and antipsychotics. When taken with sedatives, it has a relaxing effect on the nervous system and increases drowsiness.
Both medications are combined with alcohol and neutralize its effect. They have a cleansing effect, helping to remove toxic substances contained in ethanol.
Reviews
Lyudmila, Moscow: “Mexidol came up. Memory improved and vision restored. There was no such effect from analogues. It’s better to overpay a little, but be confident in the medicine.”
Margarita, St. Petersburg: “For me, there is an obvious difference in the effectiveness of the drugs. Mexidol is a universal remedy without any side effects. I sleep well, my memory has improved, I don’t feel sick, my performance has improved. Once I replaced it with Mexicor (Mexidol was not available then). At night I woke up again and could not sleep. Mexidol is more suitable."
Olga, Kazan: “My grandmother (73 years old) has been taking Mexicor for 5 years (prescribed by a doctor). During this time, all symptoms of VSD disappeared, blood pressure returned to normal, no fainting, and symptoms of heart disease decreased. And as a bonus, my memory improved.”
Roman, Nizhny Novgorod: “The drug saved me from nervousness, absent-mindedness and headaches. The doctor prescribed Mexidol, but the pharmacy offered an analogue, Mexicor. It costs less, but the results are there.”
Comparison of the effectiveness of Mexidol and Mexicor
Mexidol is more effective than Mexicor - this means that the ability of the drug substance to provide the maximum possible effect is different.
For example, if the therapeutic effect of Mexidol is more pronounced, then it is impossible to achieve this effect with Mexicor, even in large doses.
Also, the speed of therapy is an indicator of the speed of the therapeutic action; Mexidol and Mexicor are also different, as is bioavailability - the amount of a medicinal substance reaching the place of its action in the body. The higher the bioavailability, the less it will be lost during absorption and use by the body.
Comparison of addiction between Mexidol and Mexicor
Like safety, addiction also involves many factors that must be considered when evaluating a drug.
So, the totality of the values of such parameters as “o syndrome” in Mexidol is quite similar to the similar values in Mexicor. Withdrawal syndrome is a pathological condition that occurs after the cessation of intake of addictive or dependent substances into the body. And resistance is understood as initial immunity to a drug; in this it differs from addiction, when immunity to a drug develops over a certain period of time. The presence of resistance can only be stated if an attempt has been made to increase the dose of the drug to the maximum possible. At the same time, Mexidol has quite a small value of the “syndrome”, however, the same as Mexicor.
Comparison of side effects of Mexidol and Mexicor
Side effects or adverse events are any adverse medical event that occurs in a subject after administration of a drug.
Mexidol has almost the same level of adverse events as Mexicor. They both have few side effects. This implies that the frequency of their occurrence is low, that is, the indicator of how many cases of an undesirable effect of treatment are possible and registered is low. The undesirable effect on the body, the strength of influence and the toxic effect of Mexidol are similar to Mexicor: how quickly the body recovers after taking it and whether it recovers at all.