Step-by-step instructions for using Diclofenac suppositories in gynecology

Diclofenac suppositories are one of the most convenient forms of the drug, which, unlike tablets and injections, has virtually no side effects. They are administered rectally 2-3 times a day. The drug quickly eliminates pain and inhibits inflammatory processes. Admission is allowed to adults and children over 6 years old.

Composition and release form

Diclofenac suppositories are sold in pharmacies in dosages:

• 100 ml;
• 50 ml;
• 25 ml.

In one day, you can use no more than 150 ml of the drug, but even this amount should be prescribed by the attending physician.

Uncontrolled self-medication can lead to serious health consequences:

• Allergic reaction;
• Overdose;
• Exacerbation of chronic diseases, etc.

In addition to suppositories, Diclofenac is offered in the form of:

• solution for intravenous administration;
• Injections (injections);
• pills;
• gel.

Mechanism of action of Diclofenac

This drug, which belongs to the group of non-steroidal drugs, has pain relief properties.

Due to its strong composition, it breaks down arachidonic acid and reduces the level of its synthesis in the mucous membrane and kidneys.

Suppositories are used in gynecology to eliminate swelling and inflammation of the genital organs; the drug eliminates itching and burning. In therapy, the drug has practically no effect on bleeding.

The advantage of the drug is that even with prolonged use it does not lose its analgesic properties.

How does Diclofenac work?

Diclofenac is a derivative of acetic acid. It contains two chlorine atoms, one amino group, which connects two aromatic benzene rings. The synthesis of diclofenac is simple, and its effect on the body turned out to be truly unique. This yellowish crystalline powder, the potassium salt of which is highly soluble in water, turned out to be one of the most potent anti-inflammatory non-steroidal compounds, the so-called NSAIDs, currently available.

In terms of the strength of its analgesic, anti-edematous, and anti-inflammatory effects, this drug is very close to corticosteroid hormones, acts very quickly, but does not have the side effects characteristic of this class of compounds. After taking diclofenac, the patient will never develop steroid diabetes, will not have osteoporosis, and will not become overweight.

However, it should be remembered that diclofenac is an old drug that acts strongly, but rather harshly. Therefore, if you do not remember about contraindications and side effects, you can seriously pay for your health, especially with self-medication and long-term use of this drug. Unfortunately, the temptation to use diclofenac for self-medication is very great. This is one of the most accessible and inexpensive, at the same time effective drugs from the NSAID group, and it can be bought almost everywhere without a prescription. How does diclofenac work?

This molecule is able to slow down and completely stop (inhibit) the action of the enzyme cyclooxygenase, and it plays a key role in the so-called arachidonic acid inflammatory cascade. As a result, in the cells of the body that are close to the source of inflammation, the synthesis of prostacyclin and prostaglandins is disrupted, platelet aggregation decreases, and the release of biologically active amines decreases or even stops. All this leads to the fact that inflammation gradually decreases, its clinical symptoms either completely disappear or become minimal.

Let us recall that the classic symptoms of inflammation were known to the ancient Roman physician Celsus - these are redness, swelling, increased temperature or feeling of heat, as well as severe pain with dysfunction. All these signs of inflammation are clearly visible, for example, with arthritis or inflammation of the joint. The joint is both swollen and red. It is painful to move a leg or arm, and the function of this joint is impaired, which is expressed in limited range of motion.

In the case of an intervertebral hernia, redness on the skin is not visible, since we are talking about a deep inflammatory process. But swelling, plethora, a feeling of pain, pronounced muscle spasm, which is a secondary reaction to inflammation - all these are classic signs of discogenic complications of osteochondrosis.

This is what a hernia with compression of the nerve roots looks like.

Administration of diclofenac reduces all these symptoms. And, although it has absolutely no effect on the intervertebral hernia or its enlargement, the patient immediately feels much better. Therefore, diclofenac in the treatment of protrusions and hernias can be an “ambulance” remedy, which is used in a very short course, no longer than 3 to 5 days, and at the same time only relieves symptoms - plays a palliative role.

Diclofenac is just as capable of treating protrusions and hernias as drugs are able to treat malignant neoplasms. Of course, they are prescribed to patients with inoperable cancer, and the patients’ severe pain disappears, but the malignant tumor does not reduce its growth in any way from taking drugs and does not respond to them at all. In the same way, diclofenac has no effect on the cause of the disease - the protrusion or hernia itself.

Indications for use

The advantage of diclofenac is its effectiveness, pain and swelling are relieved as quickly as possible.

The main indications for use include the following:

• Diseases of the musculoskeletal system;
• Reproductive dysfunction;
• Infectious diseases;
• Diseases of extra-articular tissues;
• Swelling of soft tissues.

In the treatment of gynecological problems, suppositories are used to effectively treat dysmenorrhea and adnexitis.

In addition, Diclofenac suppositories are used to treat the following conditions:

• Hyperthermia;
• Migraine;
• Arthritis;
• Otitis, pharyngitis.

The drug is very effective for postoperative pain, accompanied by swelling and the development of inflammation.

Diclofenac suppositories help relieve pain and swelling, wherever you are. The active substance of the drug enters the body through the bloodstream and quickly spreads throughout the organs.

It is recommended to use candles at night, after all necessary hygiene procedures have been completed. It is recommended to empty your colon before doing this.

Contraindications and side effects

Despite the fact that the drug quickly and effectively eliminates health problems, it has several important contraindications that should not be taken lightly under any circumstances:

• Rectal pathologies;
• Rectal bleeding;
• Stomach ulcer;
• Intolerance to the active substance;
• Pregnancy, lactation period;
• Cardiovascular diseases;
• After coronary artery bypass surgery;
• Crohn's disease;
• Inflammation and acute intestinal diseases;
• Non-bleeding blood;
• Erosion of the gastric mucosa;
• Duodenal ulcers;
• Gastrointestinal bleeding;
• Suppression of intracerebral hemorrhage;
• High blood pressure;
• Renal dysfunction;
• Inflammation of the rectum.

In addition, Diclofenac is not recommended for use in children under 6 years of age; suppositories should not be taken by elderly patients. Its use is possible only according to the instructions and prescription of a doctor, under his supervision.

In case of an allergic reaction or intolerance, the use of the drug may cause the development of bronchial asthma.

You should take the drug very carefully if you have:

• Diabetes;
• Peripheral arterial dysfunction;
• Ulcers of the gastrointestinal tract;
• Excessive alcohol consumption, smoking.

Diclofenac should also be used with extreme caution when using anticoagulants, antiplatelet drugs, glucocorticoids and inhibitors simultaneously.

Diclofenac or surgery?

The following can be briefly said about operations. Currently, in developed countries of Western Europe, the USA, and Israel, modern minimally invasive neurosurgical intervention for protrusions and hernias is already close to the effectiveness, safety and mobility of an outpatient dental appointment. Almost always, the patient can go home on his own feet the same day or the next day after the operation, he is immediately allowed to sit, and the operation itself does not at all seem like something terrible and bloody, but simply a small and painless type of treatment.

Even in many countries of Eastern Europe, for example in the Czech Republic, neurosurgeons achieve very high results in the treatment of protrusions and hernias, and other complications of osteochondrosis if there are indications for surgery. Patients do not need to wait unsuccessfully for years, and during an exacerbation, spend a lot of money on medications, massages, chiropractors, kinesiotherapists and other specialists.

The only radical way to treat hernias and protrusions at present is modern minimally invasive neurosurgical surgery. Therefore, if only diclofenac in large doses, and especially in blockades, helps a patient with hernias, then this is a vicious path. It can cause serious complications, which will be discussed below.

The use of rectal suppositories "Diclofenac" in gynecology

Due to its wide spectrum of action and effectiveness, diclofenac suppositories are often used to treat gynecological diseases and relieve symptoms.

Indications

Diseases for which the use of the anti-inflammatory and analgesic drug Diclofenac is recommended:

1. Arthritis and rheumatism occurring with inflammation;
2. Seronegative arthritis of the spine;
3. Various inflammatory diseases of the musculoskeletal system;
4. Osteoarthritis, chronic arthritis and other etiologies;
5. Pseudosubagritic and turbid arthritis and microcrystalline arthritis;
6. Damage to rheumatic tissues;
7. Synovitis;
8. Tendinitis;
9. Bursitis;
10. Periarticular inflammation;
11. Muscle inflammation.

The active ingredient of the drug "diclofenac" is prescribed for various foci of inflammation of the musculoskeletal system, especially in which pain and discomfort develop.

As an analgesic, Diclofenac is used for injuries and other damage to soft tissues:

• After dental intervention;
• Surgical procedures;
• Migraine attacks;
• Primary and secondary attacks of adnexitis;
• Renal and biliary colic.

The drug can be used to treat symptoms, but the drug does not affect the development and progression of the disease.

Use during pregnancy

Pregnancy and breastfeeding for a woman is a period when taking any medications should be done with extreme caution. This is especially true in the third trimester of pregnancy.

Side effects from using the drug include:

• Gastritis and ulcers;
• Bronchial asthma;
• Blood clotting.

The most dangerous consequences include impaired fetal development and uterine bleeding.

If there is a need to use the drug during pregnancy, after pregnancy it is better to refrain from breastfeeding.

Instructions for use

Each suppository contains 50 mg of active ingredient.

Step-by-step instruction:

1. Before using the suppository, perform hygiene procedures using antibacterial soap and do not forget to empty your intestines first. This applies to both rectal and vaginal use.
2. Before using Diclofenac suppositories, you must wash your hands thoroughly.
3. Remove the packaging from the candle.
4. Grab the bottom of the candle with two fingers and carefully insert it to a depth of 3-4 cm. Important! If the suppository is already unpacked and the packaging is torn off, the suppository should be used immediately.
5. After use, wash your hands thoroughly.

The course of treatment includes the use of Diclofenac suppositories in gynecology for at least 3-4 days, and then to eliminate symptoms and diseases.

Scheme of administration of rectal suppositories

Dosage

The correct dosage is equally important for safe and effective treatment:

1. In the case of vaginal or rectal administration (if oral administration is intolerant), it is administered as prescribed by the doctor, depending on the development of the infection, in appropriate doses.
2. To achieve greater effectiveness, combined administration is possible, but in this case it is worth remembering that the daily dose should not exceed 150 mg.
3. Adults are prescribed a dose of 120.jpg “/>
   Diclofenac suppositories should be used with caution in combination with drugs of high hepatoxicity.

Diclofenac suppositories should be used with caution in combination with drugs that are highly hepatotoxic. These include, in particular, antibiotics and drugs for the treatment of epilepsy.

• The concentration of the drug in the blood plasma increases with the simultaneous use of drugs such as:
• Methotrexate;

Cyclosporine;

• Digoxin, etc.

ENZYME

DICLOFENAC rectal suppositories 50 mg and 100 mg

Trade name: Diclofenac

International nonproprietary name (INN): diclofenac

Dosage form: rectal suppositories

Composition: one suppository contains -

active substance: sodium diclofenac - 0.05 g; 0.1 g

excipients: solid fat - 1.2 g; 1.85 g

DESCRIPTION:

Suppositories are white or white with a yellowish tint, torpedo-shaped. On a longitudinal section there is a homogeneous mass without foreign inclusions. An air rod or funnel-shaped recess may be present. Pharmacotherapeutic group:

Non-steroidal anti-inflammatory drug (NSAID).

ATX code : М01АВ05

PHARMACOLOGICAL PROPERTIES

Pharmacodynamics:

Diclofenac has anti-inflammatory, analgesic and antipyretic effects. By indiscriminately inhibiting cyclooxygenase 1 and 2, it disrupts the metabolism of arachidonic acid and reduces the amount of prostaglandins at the site of inflammation. In rheumatic diseases, the anti-inflammatory and analgesic effect of diclofenac helps to significantly reduce the severity of pain, morning stiffness, and swelling of the joints, which improves the functional state of the joint. For injuries, in the postoperative period, diclofenac reduces pain and inflammatory swelling.

Pharmacokinetics:

When administered rectally, the maximum plasma concentration of 1.2 mcg/ml is created after 40-60 minutes. and is linearly dependent on the dose used. No changes in the pharmacokinetics of diclofenac are observed during repeated administration and do not accumulate.

Communication with plasma proteins is more than 99% (most of it is associated with albumin). Penetrates into synovial fluid. The maximum concentration in synovial fluid is observed 2-4 hours later than in plasma. The half-life from synovial fluid is 3-6 hours (the concentration of the active substance in synovial fluid 4-6 hours after administration of the drug is higher than in plasma, and remains higher for another 12 hours). The relationship between the concentration of the drug in the synovial fluid and the clinical effectiveness of the drug has not been clarified.

50% of the active substance is metabolized during the “first pass” through the liver. Metabolism occurs as a result of multiple or single hydroxylation and conjugation with glucuronic acid. The enzyme system P450 CYP2C9 takes part in the metabolism of the drug. The pharmacological activity of the metabolites is lower than that of diclofenac.

Systemic clearance is 350 ml/min, volume of distribution is 550 ml/kg. Plasma half-life -2 hours. 65% of the administered dose is excreted in the form of metabolites

kidneys; 1% is excreted unchanged, the rest of the dose is excreted in the form of metabolites in bile.

In patients with severe renal failure (creatinine clearance less than 10 ml/min), the excretion of metabolites in bile increases, but no increase in their concentration in the blood is observed.

In patients with chronic hepatitis or compensated liver cirrhosis, the pharmacokinetic parameters of diclofenac do not change.

Diclofenac passes into breast milk.

INDICATIONS FOR USE:

The drug is intended for symptomatic therapy, reducing pain and inflammation at the time of use, and does not affect the progression of the disease.

Diseases of the musculoskeletal system:

• rheumatoid arthritis,
• psoriatic, juvenile chronic arthritis,
• ankylosing spondylitis,
• gouty arthritis,
• rheumatic soft tissue lesions,
• osteoarthritis of peripheral joints and spine, including radicular syndrome,
• tenosynovitis,
• bursitis.

Pain syndrome of mild or moderate severity:

• neuralgia,
• myalgia,
• sciatica,
• post-traumatic pain syndrome accompanied by inflammation,
• postoperative pain,
• headache,
• migraine,
• algodismenorrhea,
• adnexitis,
• toothache.

As part of complex therapy for infectious and inflammatory diseases of the ear, nose and throat with severe pain (pharyngitis, tonsillitis, otitis media).

Use strictly as prescribed by your doctor.

CONTRAINDICATIONS AND SIDE EFFECTS:

• hypersensitivity (including to other NSAIDs);
• complete or incomplete combination of bronchial asthma, recurrent polyposis of the nasal mucosa and paranasal sinuses and intolerance to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (including a history);
• erosive and ulcerative lesions of the gastric or duodenal mucosa, active gastrointestinal bleeding;
• inflammatory bowel diseases (ulcerative colitis, Crohn's disease) in the acute phase;
• period after coronary artery bypass grafting;
• decompensated heart failure;
• severe liver failure or active liver disease;
• severe renal failure (creatinine clearance less than 30 ml/min), progressive kidney disease;
• confirmed hyperkalemia;
• hemostasis disorders (including hemophilia);
• III trimester of pregnancy;
• lactation period;
• children's age (up to 18 years - for suppositories of 100 mg; up to 15 years - for suppositories of 50 mg);
• rectal bleeding, hemorrhoids, trauma or inflammation of the rectum.

Carefully:

• cerebrovascular diseases,
• anemia,
• bronchial asthma,
• cardiac ischemia,
• chronic heart failure,
• congestive heart failure,
• peripheral arterial diseases,
• arterial hypertension,
• edema syndrome,
• liver and kidney failure (creatinine clearance less than 30-60 ml/min),
• dyslipidemia/hyperlipidemia,
• inducible porphyria,
• smoking,
• alcoholism,
• inflammatory bowel diseases,
• anamnestic data on the development of peptic ulcer disease of the gastrointestinal tract, the presence of Helicobacter pylori infection,
• diabetes,
• condition after extensive surgical interventions,
• diverticulitis,
• systemic connective tissue diseases.
• severe somatic diseases,
• pregnancy I-II trimester,
• elderly age,
• long-term use of NSAIDs,
• simultaneous use of glucocorticosteroids (for example, prednisolone), anticoagulants (for example, warfarin), antiplatelet agents (for example, acetylsalicylic acid, clopidogrel), selective serotonin reuptake inhibitors (for example, citalopram, fluoxetine, paroxetine, sertraline).

.

Side effect:

Frequency of all side effects:

• often - 1-10%;
• sometimes - 0.1 -1.0%;
• rarely - 0.01-0.1%;
• very rarely - less than 0.001%, including isolated cases.

From the digestive system:

• often - epigastric pain, nausea, vomiting, diarrhea, dyspepsia, flatulence, anorexia, increased aminotransferase activity;
• rarely - gastritis, proctitis, bleeding from the gastrointestinal tract (vomiting with blood, melena, diarrhea mixed with blood), gastrointestinal ulcers (with or without bleeding or perforation), hepatitis, jaundice, impaired liver function;
• very rarely - stomatitis, glossitis, esophagitis, nonspecific hemorrhagic colitis, exacerbation of ulcerative colitis or Crohn's disease, constipation, pancreatitis, fulminant hepatitis, exacerbation of hemorrhoids.

From the nervous system:

• often - headache, dizziness;
• rarely - drowsiness;
• very rarely - sensory disturbances (including paresthesia), memory disorders, tremors, convulsions, anxiety, cerebrovascular disorders, aseptic meningitis, disorientation, depression, insomnia, nightmares, irritability, mental disorders.

From the senses:

• often - vertigo;
• very rarely - visual impairment (blurred vision, diplopia), hearing impairment, tinnitus, impaired taste.

From the urinary system:

• very rarely - acute renal failure, hematuria, proteinuria, interstitial nephritis, nephrotic syndrome, papillary necrosis.

From the hematopoietic organs:

• very rarely - thrombocytopenia, leukopenia, hemolytic and aplastic anemia, agranulocytosis.

Allergic reactions:

• rarely - anaphylactic/anaphylactoid reactions, including a marked decrease in blood pressure (BP) and shock;
• very rarely - angioedema (including the face).

From the cardiovascular system (CVS):

• very rarely - palpitations, chest pain, increased blood pressure, vasculitis, heart failure (HF), myocardial infarction.

From the respiratory system:

• rarely - bronchial asthma (including shortness of breath);
• very rarely - pneumonitis.

From the skin:

• often - skin rash;
• rarely - urticaria;
• very rarely - bullous rashes, erythema, incl. multiforme, and Stevens-Johnson syndrome, Lyell's syndrome, exfoliative dermatitis, itching, hair loss, photosensitivity, purpura, incl. allergic.

Other:

• rarely - swelling.

Special instructions:

During the period of treatment with the drug, monitoring of the peripheral blood picture, liver and kidney function, and examination of stool for the presence of blood should be carried out. If, while taking the drug, the increase in the activity of “liver” transaminases persists or increases, if clinical symptoms of hepatotoxicity are noted (including nausea, fatigue, drowsiness, diarrhea, itching, jaundice), treatment should be discontinued.

Because of the important role of prostaglandins in maintaining renal blood flow, special caution should be exercised when prescribing to patients with cardiac or renal insufficiency, as well as when treating the elderly, taking diuretics, AND patients who have a decrease in circulating blood volume for any reason (eg , after extensive surgery). If diclofenac is prescribed in such cases, monitoring of renal function is recommended as a precaution. In patients with liver failure (chronic hepatitis, compensated cirrhosis of the liver), the kinetics and metabolism do not differ from similar processes in patients with normal liver function. When carrying out long-term therapy, it is necessary to monitor liver function, peripheral blood patterns, and stool analysis for occult blood. Due to the negative effect on fertility, the drug is not recommended for women wishing to become pregnant. In patients with infertility (including those undergoing examination), it is recommended to discontinue the drug. To reduce the risk of developing adverse events from the gastrointestinal tract, the minimum effective dose should be used for the shortest possible course. Patients taking the drug must refrain from drinking alcohol.

Use during pregnancy and lactation:

The use of diclofenac is contraindicated in the third trimester of pregnancy (possible suppression of uterine contractility and premature closure of the ductus arteriosus in the fetus), and in the first and second trimester its use is possible only in cases where the expected benefit to the mother outweighs the potential risk to the fetus. The drug is prescribed in the minimum effective dose.

Diclofenac and its decomposition products pass into breast milk in small quantities. If it is necessary to use the drug in high doses and for a long time, you should consider stopping breastfeeding.

Impact on the ability to drive vehicles and machinery:

During the treatment period, the speed of mental and motor reactions may decrease, so it is necessary to refrain from driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

METHOD OF APPLICATION AND DOSAGE:

Rectally. Before using the suppository, it is recommended to empty the intestines.

Suppositories 100 mg: adults: 1 suppository 1 time per day.

Suppositories 50 mg: adults and children over 15 years of age. 1 suppository 2 times a day. The maximum daily dose is 150 mg.

When used simultaneously with oral forms of diclofenac, it is rational to use a single dose of 100 mg at night (in this case, evening administration of oral forms of diclofenac is excluded).

The duration of use of the drug is no more than 7 days.

Use during pregnancy and lactation:

The use of diclofenac is contraindicated in the third trimester of pregnancy (possible suppression of uterine contractility and premature closure of the ductus arteriosus in the fetus), and in the first and second trimester its use is possible only in cases where the expected benefit to the mother outweighs the potential risk to the fetus. The drug is prescribed in the minimum effective dose.

Diclofenac and its decomposition products pass into breast milk in small quantities. If it is necessary to use the drug in high doses and for a long time, you should consider stopping breastfeeding.

Overdose:

Symptoms:

• vomit,
• bleeding from the gastrointestinal tract,
• epigastric pain,
• diarrhea,
• dizziness,
• noise in ears,
• lethargy,
• convulsions,
• rarely - increased blood pressure (BP), acute renal failure, hepatotoxicity, respiratory depression, coma.

Treatment:

symptomatic therapy aimed at eliminating increased blood pressure, renal dysfunction, seizures, gastrointestinal irritation, respiratory depression; in case of erroneous oral use of suppositories, gastric lavage and activated charcoal are recommended. Forced diuresis and hemodialysis are ineffective (due to the significant connection with proteins and intensive metabolism).

INTERACTIONS WITH OTHER MEDICINES:

Increases plasma concentrations of digoxin, methotrexate, lithium and cyclosporine.

Reduces the effect of diuretics; against the background of potassium-sparing diuretics, the risk of hyperkalemia increases; against the background of anticoagulants, thrombolytic agents (alteplase, streptokinase, urokinase) - the risk of bleeding (usually from the gastrointestinal tract). Reduces the effects of antihypertensive and hypnotic drugs.

Cefamandole, cefoperazone, cefotetan, valproic acid and plicamycin increase the incidence of hypoprothrombinemia.

Cyclosporine and gold preparations increase the effect of diclofenac on the synthesis of prostaglandins in the kidneys, which increases nephrotoxicity.

Simultaneous administration with ethanol, colchicine, corticotropin and St. John's wort preparations increases the risk of bleeding in the gastrointestinal tract.

Diclofenac enhances the effect of drugs that cause photosensitivity.

Drugs that block tubular secretion increase the plasma concentration of diclofenac, thereby increasing its toxicity.

Concomitant use with paracetamol increases the risk of developing nephrotoxic effects of diclofenac.

Increases the likelihood of side effects of other NSAIDs and glucocorticosteroids (gastrointestinal bleeding), methotrexate toxicity and cyclosporine nephrotoxicity.

Acetylsalicylic acid reduces the concentration of diclofenac in the blood. Reduces the effect of hypoglycemic drugs.

RELEASE FORM:

Rectal suppositories 50 mg, 100 mg.

5 suppositories per blister pack made of polyvinyl chloride film. 2 blister packs along with instructions for use in a cardboard pack.

CONDITIONS FOR DISCHARGE FROM PHARMACIES:

Dispensed by prescription.

BEST BEFORE DATE:

2 years. Do not use after expiration date.

STORAGE AND TRANSPORTATION:

In a dry place, protected from light, at a temperature not exceeding 25 ° C.

Keep out of the reach of children.

Overdose

In Diclofenac suppositories and ointments, the concentration of the active substance is very low, so there are practically no cases of overdose.

In rare cases of inappropriate drug combinations or individual intolerance, side effects associated with overdose are possible, such as:

• Nausea;
• Vomit;
• Bleeding in the abdomen;
• Migraine;
• Diarrhea;
• Convulsions;
• Dizziness, fainting;
• Tinnitus;
• Kidney failure;
• Complaints.

Treatment of overdose consists of eliminating symptoms.

Use for cystitis

Diclofenac is often used to treat and prevent cystitis, and suppositories are also very effective in the treatment of other urological diseases. In this case, the drug completely restores the bladder mucosa.

They must be used strictly according to the instructions:

1. For cystitis, you need to administer 1 suppository 2 times a day.
2. Remove the packaging from the suppository and insert it into the rectum.
3. Before this, an organ with urine is needed.
4. For medicinal purposes, no more than 3 suppositories can be administered into the stool.
5. The course of treatment for cystitis with Diclofenac should not exceed 7 days. If the condition has not changed, you need to see a doctor, get tested, get tested.
6. The active ingredient diclofenac dissolves in the human body within 30 minutes, but is excreted only after 4 hours.

About blockades

Diclofenac is also widely used for paravertebral blockades, when it is injected directly into the deep muscles of the back. In addition to diclofenac, there may be glucocorticosteroid hormones, chondroprotectors, hyaluronic acid substitutes, and almost always a local anesthetic, for example, Lidocaine, is administered along with them. Such a therapeutic blockade breaks the pathological circle between spasm and pain, and the patient, who was brought to the hospital on a gurney, can, after installing the blockade, slowly go home on his own feet.

However, despite the rapid elimination of pain and inflammation, the blockade is not a radical cure, and blockades are indicated just in the first days of an exacerbation in the presence of protrusion and especially a hernia, with significant severity of persistent pain. If all means of treatment have ceased to help the patient, and only blockades help, then this is a sure sign that the patient already needs neurosurgical intervention or surgery.

Suppositories for hemorrhoids

Many patients wonder how effective is the use of Diclofenac suppositories for hemorrhoids?

Experts do not recommend using this drug; there are more effective drugs with fewer side effects.

For acute hemorrhoids, this remedy is strictly prohibited. Otherwise, the course of the disease may be greatly aggravated by bleeding and severe pain.

The drug "Diclofenac" can be used for the development of hemorrhoidal nodules only on those areas of the skin that are not damaged by cracks or bleeding.

It should be used only with a prescription and under the supervision of a doctor; the course should also be prescribed by a specialist.

The drug "Diclofenac" with long-term use can cause addiction and serious deterioration of the condition.