Comparing Dolobene and Diclofenac | Determining the best

Updated: 04/23/2021 15:12:56

Expert: Abramova Tsilya

Painkiller gels Dolobene and Diclofenac are very popular, but it’s not so easy to immediately say which is better. We analyzed their advantages and disadvantages in order to understand under what conditions it is better to choose one or another remedy.

Comparison of the effectiveness of Voltaren emulgel and Dolobenya

The effectiveness of Voltaren emulgels is quite similar to Doloben - this means that the ability of the drug substance to provide the maximum possible effect is similar.
For example, if the therapeutic effect of Voltaren emulgels is more pronounced, then using Doloben even in large doses will not achieve this effect.

Also, the speed of therapy is an indicator of the speed of the therapeutic action; Voltaren emulgels and Dolobenya are approximately the same. And bioavailability, that is, the amount of a drug reaching its site of action in the body, is similar. The higher the bioavailability, the less it will be lost during absorption and use by the body.

Which drug is better

Dolobene is best used for injuries with the appearance of hematomas, varicose veins, sprains, and swelling. Diclofenac effectively copes with muscle pain after physical activity, as well as in rheumatic diseases.

Both products contain potent substances that can provide pain relief. When choosing a remedy, you need to look at the limitations and side symptoms. When both drugs meet all parameters, the price category becomes important. Diclofenac wins in this, its price is lower due to the domestic manufacturer.

Local remedies can be used without a doctor's permission, but not for long. When long-term use of the drug is necessary, you should consult. Self-medication can be dangerous.

Comparison of the safety of Voltaren emulgels and Dolobenya

The safety of a drug includes many factors.

At the same time, Voltaren emulgels are quite similar to Doloben. It is important where the drug is metabolized: drugs are excreted from the body either unchanged or in the form of products of their biochemical transformations. Metabolism occurs spontaneously, but most often involves major organs such as the liver, kidneys, lungs, skin, brain and others. When assessing the metabolism of Voltaren emulgels, as well as Doloben, we look at which organ is the metabolizing organ and how critical the effect on it is.

The risk-benefit ratio is when the prescription of a drug is undesirable, but justified under certain conditions and circumstances, with the obligatory observance of caution in use. At the same time, Voltaren emulgels do not have any risks when used, just like Doloben.

Also, when calculating safety, it is taken into account whether only allergic reactions occur or possible dysfunction of the main organs. In other matters, as well as the reversibility of the consequences of using Voltaren emulgel and Dolobenya.

Description of Dolobene

Dolobene is a local analgesic drug, produced in the form of a gel and ointment. It is an anti-inflammatory, anticoagulant, analgesic and decongestant. The composition contains heparin, DMSO and dexpanthenol. Manufactured by Merckle in Germany.

Dimethyl sulfoxide (DMSO) has an analgesic, decongestant effect, and helps reduce the severity of inflammation. The substance inactivates radicals that are actively produced during the inflammatory process.

DMSO has a local analgesic effect. The decongestant effect of Dolobene is due to the improvement of subcutaneous reactions. DMSO penetrates the skin, helping to better absorb other drugs.

Heparin exhibits an antithrombic effect and helps tissue restoration by inhibiting a component such as hyaluronidase.

Dexpanthenol, when used topically, is converted to pantothenic acid when used topically. The effectiveness of this substance is comparable to the effectiveness of vitamin B. The acid is involved in various catabolic processes due to epithelization of damaged skin and stimulation of granulation.

Research and effectiveness

Dolobene has a combined beneficial effect:

1. analgesic, decongestant;
2. regenerating;
3. antithrombic.

Dolobene can be recommended in the complex treatment of arthritis, neuralgia, thrombophlebitis, soft tissue compression and other injuries.

The main advantage of the gel is its rapid combined effect. It differs from Diclofenac in that, in addition to pain relief, it is used to prevent blood clots.

Unlike many other local NSAIDs, Dolobene can be used from the age of 5, which expands the scope of its application.

The drug has a quick and pronounced effect due to its impact on different parts of the pathological process - inflammation, pain, swelling. The DMSO in the composition serves as a kind of conductor that accelerates the flow of medicinal substances to the source.

Source:

Dolobene gel: complex therapy of pain syndrome in diseases of the musculoskeletal system. Suprun E.V. Man and medicine. 2021.

Contraindications

The product for local use Dolobene is not used in the following conditions:

1. intolerance to components;
2. asthma;
3. severe cardiovascular diseases;
4. severe renal and liver dysfunction;
5. pregnancy, lactation, up to 5 years;
6. open wounds.

There is no data on use during pregnancy. Therefore it is contraindicated. DMO passes into mother's milk, so it is also not used during lactation.

Side symptoms

When using Dolobene, there is a risk of local reactions in the form of itching, burning, and redness. They usually go away on their own and do not require discontinuation of the drug.

DMSO may cause allergies. During the use of Dolobene, there may be a garlic odor from the mouth, which is caused by a product of DMSO metabolism - dimethyl sulfide. Taste sensations may also change.

In very rare cases, angioedema and urticaria appear. When applying the product to a large area of ​​the body, systemic reactions may occur - nausea, chills, shortness of breath, headache.

Dosage

Dolobene is used only topically. The gel is applied 2-4 times/day. When using a bandage, wait a few minutes before applying it. The duration of therapy differs depending on the severity of the disease.

There is no data on an overdose of Dolobene.

Who is it suitable for?

Dolobene is good to use for:

1. bruises;
2. tendon inflammation;
3. swelling;
4. injuries with tendon sprains;
5. closed bruises;
6. epicondylitis;
7. periarthritis;
8. neuralgia.

Comparison of addiction between Voltaren emulgels and Dolobenya

Like safety, addiction also involves many factors that must be considered when evaluating a drug.

So, the totality of the values ​​of such parameters as “syndrome”, in Voltaren emulgels is quite similar to the similar values ​​in Doloben. Withdrawal syndrome is a pathological condition that occurs after the cessation of intake of addictive or dependent substances into the body. And resistance is understood as initial immunity to a drug; in this it differs from addiction, when immunity to a drug develops over a certain period of time. The presence of resistance can only be stated if an attempt has been made to increase the dose of the drug to the maximum possible. At the same time, with Voltaren emulgels the meaning of the “syndrome” is quite small, however, the same as with Doloben.

Description of Diclofenac

Diclofenac is available in different dosage forms - tablets, solution, gel, ointment, suppositories. Contains the active ingredient of the same name – diclofenac sodium. 1 g of gel contains 50 mg. The drug is produced in Russia, Serbia, Ukraine, Romania, Belarus, and India.

Diclofenac gel is a topical NSAID used for muscle and joint pain. The drug has a pronounced analgesic, antipyretic, antirheumatic, anti-inflammatory effect.

Research and effectiveness

Osteoarthritis is a common pathology, occurring in 10% of the total population. The pathological process is based on damage to all components of the joint. A common complaint with this condition is pain. Diclofenac is considered as a drug for the relief of pain in osteoarthritis.

Diclofenac, in comparison with placebo, shows the greatest effectiveness after a 2-3-week course of use. The use of a topical drug with a higher safety profile is considered as an alternative to systemic NSAIDs.

When comparing the effectiveness of Diclofenac gel with Ibuprofen in tablet form, the response rate was 40% and 34%, respectively.

Diclofenac can be recommended in the complex treatment of joint pathology. It will also be a good measure for preventing pain in rheumatic diseases.

Source:

The effectiveness of local forms of Diclofenac in relieving pain in osteoarthritis. Ukrainian Rheumatological Journal. Lukyanchuk E. 2015.

Contraindications

Diclofenac in gel form should not be used in case of hypersensitivity to the composition and intolerance to NSAIDs. It is contraindicated when there is a history of attacks of bronchial asthma, acute rhinitis, urticaria, which are caused by taking ASA.

The third trimester of pregnancy is a strict contraindication; it can be used in the 1st and 2nd trimesters when there are compelling reasons and the benefit outweighs the risk.

Diclofenac in the form of a gel, unlike tablets and solution, is safer, so there are much fewer restrictions on its use.

Side symptoms

Diclofenac is well tolerated when used topically. Rarely, temporary skin reactions may occur due to allergies. Other uncommon side effects are angioedema, asthma, rash, contact dermatitis, erythema, photosensitivity.

Dosage

Diclofenac gel can be used from 14 years of age. Apply 3-4 times/day with massage movements. The duration of use depends on the disease. Diclofenac should not be used for more than two weeks. When long-term therapy is needed, you should consult your doctor.

Diclofenac in the form of a gel has low adsorption, so overdose is almost completely excluded. If the product is swallowed, systemic reactions may already occur. Then you urgently need to rinse your stomach and take enterosorbent.

Who is it suitable for?

Indications for the use of Diclofenac are pain and inflammation of muscles, joints, and tendons. Can be used for rheumatic diseases. Relieves pain and inflammation after injuries.

Diclofenac is good to use for muscle tension and soreness after physical training, to relieve pain during exacerbation of radiculitis. It also serves as a good prevention of muscle pain in rheumatic diseases.

The gel can be used for a short course during exacerbation of diseases of the spine and joints, when the pain is short-term. It can be used to prevent muscle pain immediately after high physical activity.

Comparison of side effects of Voltaren emulgel and Dolobenya

Side effects or adverse events are any adverse medical event that occurs in a subject after administration of a drug.

Voltaren emulgels have almost the same level of adverse events as Doloben. They both have few side effects. This implies that the frequency of their occurrence is low, that is, the indicator of how many cases of an undesirable effect of treatment are possible and registered is low. The undesirable effect on the body, the strength of influence and the toxic effect of Voltaren emulgels is similar to Doloben: how quickly the body recovers after taking it and whether it recovers at all.

What is the best way to remove moles and warts?

Skin formations, which are often perceived only as a cosmetic defect, require particularly close attention from doctors and competent diagnosis, since they can degenerate into malignant ones. Therefore, the decision - to remove, examine or treat - must be made by the doctor. Currently, aesthetic medicine has a large arsenal of methods for removing various growths on the skin. Acid-containing drugs, which can be easily purchased in city pharmacies, destroy tumor tissue when applied locally. However, you should not self-medicate, since the drug must be used in strict doses, by a specialist with experience in its use. If applied in excess

The acid gets into the surrounding skin and a deep burn develops, resulting in a rough scar. Chemical means also include cryodestruction - removal with liquid nitrogen. Its main advantage is that the tissue destroyed by the cold is not removed, but remains in place, playing the role of a kind of “bandage” that covers and protects the wound from infection.

All this time, the area of ​​treatment does not need treatment and can be wetted several hours after the operation, which is very convenient, for example, when removing formations from the skin of the hands. However, this method also has its disadvantages - it is not always possible to accurately control the depth of impact. Therefore, the possibility of burns to surrounding tissues cannot be ruled out, which may result in a scar. There is also the possibility that the tumor may not be completely eliminated, in which case a repeat procedure will be required.

Basic hardware removal methods

come down to their surgical excision, electro- and laser coagulation. Surgical excision is a traditional method of removing tumors, which is still common and sometimes irreplaceable, for example, if it is necessary to cope with a sufficiently deep or large skin formation. However, the surgeon's intervention leaves scarring on the skin.

Electrocoagulation method

allows you to remove the tumor in one go, and samples of removed tissue can be used for additional tests. This method allows you to control the depth of the effect, but the electric current causes volumetric thermal damage to the tissue around the removed area; a dry crust appears at the operation site, which must be protected from water and the effects of cosmetics for 5-7 days, and get rid of it ahead of schedule (14 -20 days) is not worth it to get the best cosmetic result. This causes a lot of inconvenience to patients.

Recently, removal of benign tumors with a carbon dioxide laser has been widely used.

Its scanning effect allows you to control the depth of penetration into the skin, which minimally damages the surrounding tissues. During the operation, the vessels are coagulated, which makes the procedure bloodless. The postoperative wound becomes covered with a black crust (necrosis of the underlying tissue occurs), which does not look very aesthetically pleasing and requires careful care, as after electrocoagulation.

Another disadvantage

laser beam is the impossibility of conducting additional studies of the tumor after removal (which is necessary to confirm the diagnosis and exclude malignant growth), due to its complete combustion.

Radiosurgery

is a new, gentle method for removing skin tumors. The principle of the effect of radio waves on tissue is very similar to a laser - the evaporation of cells, but numerous studies have shown that an incision with their help causes the least trauma to tissues compared to other methods and the healing process is more active.

Immediately after removal, a small wound the color of normal skin will appear on the skin, which is lubricated with wound-healing creams or gels, it can be wetted and after 5 days it will be covered with new epithelium. This course of the postoperative period does not require time for rehabilitation and allows you to lead a normal lifestyle.

The radiosurgical method has a good cosmetic effect:

It is often difficult to find the surgical site due to the complete restoration of the structure and relief of the skin. In addition, removing a skin tumor with a radio wave will cost much less than laser due to the cost of the equipment.

It should be noted that the use of modern technologies for various interventions often depends on the availability of certain equipment in the clinic. The use of each type of high-energy radiation has its own indications, taking into account their effects on certain tissues, which can only be determined by a specialist.

The radiosurgical method is successfully used in the Allergy and Acid Center using the Surgitron apparatus.

Dermatologist-cosmetologist, candidate of medical sciences,
Natalya Mamula Return to list

Comparison of ease of use of Voltaren emulgel and Dolobenya

This includes dose selection taking into account various conditions and frequency of doses. At the same time, it is important not to forget about the release form of the drug; it is also important to take it into account when making an assessment.

The ease of use of Voltaren emulgels is approximately the same as Doloben. However, they are not convenient enough to use.

The drug ratings were compiled by experienced pharmacists who studied international research. The report is generated automatically.

Last update date: 2020-12-04 13:44:26