Nithya (Nitya): Restoring the collagen structure of the skin in 3 procedures!

Verified by an expert
Avdeyuk Elena Vladimirovna Dermatovenerologist, cosmetologist

Publication date: November 04, 2021

Review date: November 11, 2021

Collagen is something without which our skin cannot exist. She ages, fades, fades. Collagen itself is not replenished. And its reserves cannot be replenished by consuming drugs containing collagen. It is possible to replenish the level of this essential protein in the body only through injections.

Collagen Nithya (Nithiya) is a unique preparation of biological origin, the structure of which is as close as possible to the structure of collagen produced by the human body. When introduced into the layers of the epidermis, it slows down the aging process and triggers the production of its own collagen. The action of the drug Nitiya exactly reproduces the physiological process of regeneration of the extracellular matrix.

As a result, the skin becomes smoother, elastic, dense, and wrinkles and scars are smoothed out. After the first procedure, the skin acquires a healthier and more youthful appearance, and after a course of procedures this effect is consolidated.

The developer of the drug is Euroresearch srl, a pharmaceutical holding company founded in 1983. The company has an impeccable reputation as a reliable partner and leading developer of collagen-containing products. The company's portfolio includes a wide range of patented drugs developed on the basis of its own laboratory and R&D department.

All products of the Euroresearch srl holding are manufactured in accordance with high CE, ISO and GMP standards. For more than 30 years, Euroresearch srl has been successfully operating on the international market and is represented in the countries of Central and Eastern Europe, Asia and the USA.

Causes of decreased collagen levels in the skin

There are 19 types of collagen. Different types predominate in different tissues, which in turn is determined by the role that collagen plays in a particular organ or tissue.

The dermis mainly contains collagen types I (reticular layer) and type III (papillary layer). Type I makes up 80 to 85% of the dermal matrix and is responsible for elasticity. Type I collagen is responsible for the youth of our skin. The third type of collagen is the second most important, making up 10 to 15% of the matrix. The fibers have a smaller diameter compared to type I collagen fibers and form smaller bundles, providing flexibility to the skin.

In young skin, collagen fibers of types I (80%) and III (15%) predominate. With age, the content of type 1 collagen decreases. Every year the amount of collagen in the skin decreases by an average of 2 percent.

The structure of proteins can be damaged by exposure to ultraviolet light (a process known as photoaging), reactive oxygen species (peroxidation), excessively high blood sugar (glycation), toxins, bacteria and viruses, heavy metals and other substances with which organism interacts. In youth, the natural processes of destruction (degradation) of old collagen and synthesis of new collagen are balanced. But with age, the balance shifts in favor of destruction. Especially for women. Because metabolic processes in the body are just beginning to slow down.

The fact is that most metabolic processes in the female body are regulated by sex hormones - estrogens. Collagen metabolism is no exception. But the amount of estrogen decreases over the years.

Gutsenko Liliya Anatolevna

Cosmetologist

The decrease in estrogen levels in the female body begins after 35 years. It is then that the first “bells” appear, notifying about a lack of collagen: the elasticity of the skin decreases, the skin itself becomes drier, and the first wrinkles appear. After 40 years, the decrease in the level of female sex hormones becomes noticeable, and it begins to fall very quickly during premenopause and in the first years after menopause.

Because of this, collagen synthesis slows down. Following the skin, the hair becomes dry and brittle, the nails begin to grow worse and become thinner. Then problems with joints appear (osteochondrosis, arthrosis), muscles lose elasticity. Bones also become fragile - not only calcium and vitamin D are important for them, but also collagen, which makes up the elastic framework of bone tissue, in the cells of which calcium compounds are deposited, giving bones strength.

The drug Nithya (Nithiya) consists of microparticles of heterologous type I collagen. The technology for its production was developed and patented by the Italian company EURORESEARCH. It is considered one of the leaders in the market of innovative high-quality collagen-based products. The drug is approved by the American Food and Drug Administration (FDA). In Russia, the drug was registered in 2021 (RU No. P3H 2019/9019 dated October 9, 2021). CE certified - meets European quality standards

Instructions for use

According to the instructions for use, Collagen Ultra should be used after consultation with a doctor. The drug is intended to eliminate painful symptoms of joint pathologies. Taking powders with collagen or applying cream and gel locally for pathogenetic treatment is not advisable. An integrated approach is used to treat arthritis and arthrosis. Drugs of various clinical and pharmacological groups, physiotherapy, massage, and exercise therapy are used.

Indications and contraindications

Collagen Ultra is included in therapeutic regimens for the treatment and prevention of diseases of the musculoskeletal system. The cream and gel are actively used for the rapid recovery of patients after joint injuries. These are fractures, dislocations, subluxations, bruises, ruptures of muscles, ligaments, tendons. Medicines quickly eliminate inflammatory edema, extensive hematomas, and pinpoint hemorrhages. Collagen Ultra is prescribed to patients after diagnosing the following pathologies:

• rheumatoid, gouty, reactive arthritis;
• cervical, thoracic, lumbosacral osteochondrosis;
• lumbago, lumboischialgia;
• protrusion, intervertebral hernia;
• intercostal neuralgia;
• arthrosis of any localization;
• chronic bursitis, tendinitis, synovitis, tendovaginitis;
• humeroscapular periarthritis;
• lateral or medial epicondylitis.

The drug is recommended for use for aching pain. They occur due to hypothermia, changes in weather, after physical exertion. It can be prescribed in the postoperative period to speed up rehabilitation.

The main contraindication to the use of cream and gel is individual intolerance to the active or auxiliary ingredients.

Directions for use and doses

Collagen Ultra gel and cream with glucosamine are intended for long-term course treatment. They are distributed in a thin layer on the skin and rubbed in with light massaging movements up to 4 times a day. Due to the presence of hot pepper extract, the product should not be applied under occlusive dressings.

Single doses depend on the size of the affected joint. When calculating them, the doctor must take into account the type of pathology, the form of its course, and the number of complications that have arisen.

Side effects and special instructions

The drug is non-toxic, since the ingredients do not penetrate the bloodstream and do not cause adverse systemic manifestations. But if the dosage regimen is violated, local allergic reactions may develop. They are clinically manifested by a rash, swelling, redness of the skin, itching and burning. It is necessary to quickly remove the product from the skin with warm water and soap. Then you should take an antihistamine tablet (Cetrin, Loratadine) and seek medical help.

During pregnancy and lactation, external agents can be used only as prescribed by the attending physician. Therapy for patients with severe liver and kidney diseases is carried out under the supervision of an orthopedist, rheumatologist, and neurologist.

Main features of the biological product Nitiya

The thread consists of microparticles of heterologous type I collagen, isolated using innovative technology invented and patented by Euroresearch srl (Italy). The extraction process does not change the natural structure of the protein and does not involve chemical cross-linking. Biomimetic collagen microparticles actively stimulate fibroblasts and the production of procollagen fibers.

When injected with the collagen-containing drug Nithya, the regeneration of the extracellular matrix, identical to the natural one, is triggered. This allows you to achieve a quick and lasting rejuvenating effect. Safety and absolute hypoallergenicity of the product is achieved by separating the triple collagen helix from the N and C terminal amino acids.

Collagen fiber maintains its natural triple helical structure, molecular weight and molecular chain sequence, minimizing the possibility of allergies and complications.

Comparative analysis of treatment of patients in groups A and B

A comparison of the results of treatment of patients in groups A and B demonstrated some differences, indicating the effectiveness of the drug "Collagen Ultra" in comparison with the existing practice of conservative treatment. It was noted that the use of the drug significantly reduces the reduction time of such manifestations of the disease as pain and inflammation in the joints, stiffness regressed and the range of movements in the joints increased. The patients' mood and thus their quality of life improved. At the same time, the studied parameters (clinical and laboratory - Table 4) turned out to be comparable.

Dynamics of changes in peripheral blood parameters during treatment

Dynamics of changes in peripheral blood parameters during treatment

Treatment with the Collagen Ultra complex of drugs allows you to reduce both the treatment time and the hospital period, which is important for medical institutions. The drug demonstrated a better safety profile compared to traditional treatment tactics.

Important features of Collagen Ultra products include high clinical effectiveness and ease of use, which provides significant economic and clinical benefits (reduction in the number of procedures, errors in drug dosing).

Conclusion

The use of Collagen Ultra in the complex therapy of patients with dystrophic-degenerative joint changes is one of the important directions in the treatment of these current diseases. The clinical study demonstrated the high clinical effectiveness of the combined drug “Collagen Ultra” in the treatment of patients with damage to the joints and spine. This drug is a source of biologically active low-molecular polypeptides and amino acids, which are building materials for the elements of the musculoskeletal system, helping to strengthen and restore the connective tissue, including. and cartilage tissue.

Considering the complex effect on all symptoms of a chronic pathological process, as well as a good safety profile and pharmacoeconomic feasibility, we can talk about Collagen Ultra products as an important, additional method of treating these diseases.

conclusions

The Collagen Ultra series of products is well tolerated, has pleasant organoleptic properties and does not cause unwanted reactions.

The Collagen Ultra series of products has an analgesic, anti-inflammatory, metabolic effect and can be recommended in the complex treatment of patients with chronic lesions of the musculoskeletal system.

The Collagen Ultra series of products helps reduce dystrophic-degenerative changes in joints, improve joint mobility and increase the patient’s activity level.

"Collagen Ultra" in cream and gel forms does not have an irritating effect, reduces inflammatory reactions and pain, and helps restore connective tissue, including. and cartilage tissue in the lesions.

The Collagen Ultra complex of products is safe and convenient to use and is recommended for use in inpatient and outpatient settings in complex treatment.

Indications for use of collagen Nitiya

• Therapy for chrono- and photoaging of the skin of the face, neck, décolleté and hands.
• Regeneration of dermal and subdermal connective tissue through stimulation of fibroblasts and the process of neocollagenesis.
• Correction of genetic deformations such as dermal hypotrophy and hypotonia, as well as reduced skin elasticity.
• Correction of scars and stretch marks.
• Preparation for plastic surgeries, medium peels, laser resurfacing and recovery after them.

Nithium injections make it possible to improve skin microcirculation, replenish collagen deficiency, and stimulate cells responsible for the production of substances that help us look young and beautiful. This technique can be used as monotherapy or in combination with laser procedures, peelings, mesotherapy, etc.

Threading is used to treat the face and body, including areas such as the forehead, eyebrows, nasolabial folds, chin, neck, décolleté, arms, chest, abdomen, buttocks and thighs.

Contraindications

The manufacturer indicates that the drug is not recommended for use by some categories of patients. Thus, the effectiveness and safety of the drug is not guaranteed when used by pregnant and breastfeeding women, people with autoimmune diseases, diabetes and a tendency to form keloid scars.

Nitya helps achieve the following results:

• improving skin quality;
• skin toning;
• reducing wrinkles in the correction area;
• restoration of the natural oval of the face;
• return of lost volumes.

FAQ

Question: What should not be done after the procedure?

Answer: After the procedure, you should not wet your face for four hours. It is recommended to refrain from applying decorative cosmetics for 24 hours after the injection. It is also not recommended to visit the bathhouse/sauna, beach or solarium for 3-4 days.

Question: How does collagen therapy differ from mesotherapy?

Answer: If you want to saturate your skin with vitamins and other useful substances, then you need to undergo a course of mesotherapy. Collagen therapy is aimed at the growth of new collagen threads, which are tightly woven into the skin as a “framework”, making it elastic. Procedures can be combined to enhance the effect.

Question: What effect do creams with collagen or collagen tablets give?

Answer: They definitely will not increase the level of collagen in the skin. Neither creams, nor masks, nor drinks or tablets with collagen can saturate the skin with nutrients from the inside as much as deep injections.

Question: How long does the effect last?

Answer: From a year to a year and a half. The timing varies depending on the severity of the problem and the individual characteristics of the patient’s body.

Description of the drug

For treatment of the spine and joints, a course of Collagen Ultra is required. Its active components accumulate in pathological foci, gradually exerting a therapeutic effect. The combined local remedy is used to treat both inflammatory and degenerative diseases. Why do doctors include cream and gel in treatment regimens:

• reduction in the severity of symptoms - nagging, aching pain, stiffness, morning swelling of the joints;
• prevention of the progression of aseptic inflammation, its spread to healthy connective tissue structures;
• reducing the pharmacological load on the body by reducing doses of systemic drugs;
• partial regeneration of cartilage tissue as a result of replenishment of collagen reserves.

The cream has a dense thick consistency, white color and a pleasant aroma of essential oils. Gel is a jelly-like transparent substance with the smell of medicinal plants. Despite the similarity of most ingredients, they are not always interchangeable.

The cream is used to relieve symptoms of chronic pathologies. And the components of the gel penetrate tissues faster, which makes it possible to use it in the treatment of diseases in a subacute form.

Clinical and pharmacological group

The external agent Collagen Ultra is included in the group of bioactive additives for the treatment of symptomatic treatment of joint pathologies.

pharmachologic effect

The therapeutic properties of the combination product are based on the pharmacological actions of their ingredients. Collagen Ultra (cream and gel) contains phytoextracts of medicinal plants and healthy oils. Each component has its own clinical activity. And their combination causes a pronounced multifaceted effect on the human musculoskeletal system:

• relief of the inflammatory process by improving blood circulation and microcirculation;
• stimulation of increased production of the body’s own collagen and other chondroprotectors;
• accelerating the removal of tissue breakdown products from joints, vertebrae and intervertebral discs;
• improvement of trophism as a result of eliminating the deficiency of nutrients and oxygen in cells;
• reducing the severity of pain due to irritation of sensitive nerve endings located in the subcutaneous tissue.

The cream contains glucosamine, a chondroprotector that stimulates the restoration of damaged articular cartilage. As it accumulates in the body, it exhibits anti-inflammatory, decongestant, and analgesic activity.

The use of any dosage form of Collagen Ultra helps strengthen joints and spinal segments. The strength and elasticity of muscles, ligaments, tendons increases, and the condition of blood vessels improves. Stiffness of movements, clicks when flexing and extending large and small joints disappear.

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Release form and composition

The medicine is packaged in polymer tubes of 75.0 g. They are placed in cardboard boxes along with instructions for use. The active ingredients of the gel are collagen, phytoextracts of mint, sage, pine, lingonberry leaf. Capsaicin, rosemary and fir essential oils also have an analgesic effect. The auxiliary composition of the gel is represented by water, methylparaben, propylparaben, hydroxyethylcellulose, sodium carboxyethylcellulose. The active composition of Collagen Ultra cream is formed from the following components:

• glucosamine sulfate;
• phytoextracts of horsetail, wormwood, burdock;
• collagen (fibrillar protein that forms the basis of the body’s connective tissue):
• capsaicin;
• fir, eucalyptus, lemon, rosemary essential oils.

The cream and gel also contain urea, soybean oil and glycerin. These ingredients moisturize the skin and prevent moisture evaporation. Auxiliary components accelerate the absorption of chondroprotectors, phytoextracts, and essential oils. They also provide long-term positive treatment results due to the gradual release of biologically active substances.

In addition to external agents, the Collagen Ultra therapeutic line includes powders for dissolution in water. Their course intake stimulates collagen production and strengthens the body's defenses.

Doctors often recommend that patients combine drugs for internal and external use. This is especially true for chronic, progressive pathologies, such as coxarthrosis or gonarthrosis.

Storage conditions and periods

The shelf life of Collagen Ultra is 24 months. Cream and gel should be stored at room temperature, away from sunlight. The spoilage of drugs is indicated by a change in their color, smell, or consistency. After opening the polymer tube, medications should be used within 2-3 months.