Prohibited during pregnancy
Prohibited during breastfeeding
Prohibited for children
Has restrictions for older people
Prohibited for liver problems
Prohibited for kidney problems
Meloxicam is produced by many pharmaceutical companies in different countries. The drug belongs to non-steroidal anti-inflammatory drugs (NSAIDs). The most common area of its application is joint, bone and muscle pain of various origins.
The problem with many anti-inflammatory drugs is the development of atrophic gastritis with long-term use. Meloxicam and its structural analogues are more gentle on the gastric mucosa and are less likely to lead to its atrophy and the development of erosions. This allows you to use high doses for better effect.
Efficacy and safety of Meloxicam
Unlike many other NSAIDs that inhibit COX-1, the action of Meloxicam is aimed at inhibiting COX-2. This allows you to relieve inflammation without affecting the gastrointestinal mucosa. The medicine is characterized by a rapid onset and duration of action for at least 12 hours.
The medication is produced not only in the form of tablets, like many similar drugs, but also in the form of rectal suppositories and a solution for injection. Its use is contraindicated during pregnancy and breastfeeding due to the high risk of complications in the child, including stillbirth. The maximum permissible daily dose of the drug is 15 mg.
Pharmacodynamics and pharmacokinetics
The principle of action of the drug Meloxicam is based on the selective suppression of the enzymatic activity of cyclooxygenase-2 , on the inhibition of the process of prostaglandin . The selectivity of cyclooxygenase-2 decreases with long-term therapy with Meloxicam in high dosages.
The drug suppresses to the greatest extent the synthesis of prostaglandins in the inflammatory focus compared to kidney tissue and the gastric mucosa. Meloxicam is less likely to cause erosive and ulcerative lesions of the digestive tract.
Contraindications
Meloxicam tablets are not prescribed for the so-called “aspirin” triad (intolerance to pyrazolone , acetylsalicylic acid , bronchial asthma and recurrent nasal polyposis ).
The drug is not used for severe pathology of the renal system, breastfeeding , pregnancy , ulcerative lesions of the digestive tract , intolerance to drugs of the NSAID .
Suppositories are not prescribed for diseases of the anus and rectum of inflammatory origin.
Meloxicam should be prescribed to elderly people with caution.
Before using the drug, be sure to consult your doctor.
Side effects
- Digestive tract: hidden and obvious gastrointestinal bleeding , erosive and ulcerative lesions of the digestive tract, increased levels of liver enzymes, epigastric pain, belching , vomiting , nausea , flatulence , stool disorders in the form of constipation or diarrhea syndrome .
- Nervous system: increased drowsiness , headaches , dizziness .
- Hematopoietic organs: thrombocytopenia , leukopenia , anemia .
- Allergic reactions in the form of blisters , skin rashes , itching .
- Urinary system: increased urea levels, hypercreatininemia , swelling .
- Cardiovascular system: rapid heartbeat, blood flushes to the upper chest, to the skin of the neck and face, increased blood pressure.
Rarely, medullary renal necrosis , glomerulonephritis , interstitial nephritis , and nephrotic syndrome . Possible ringing in the ears .
Overdose
Symptoms of an overdose with Meloxicam: drowsiness, impaired consciousness, nausea, vomiting, epigastric pain, gastrointestinal bleeding, acute renal failure, changes in blood pressure, respiratory arrest, asystole.
Treatment: there is no specific antidote. In case of drug overdose, carry out symptomatic therapy. Forced diuresis, alkalization of urine, hemodialysis are ineffective due to the high binding of the drug to blood proteins.
Instructions for use of Meloxicam (Method and dosage)
Meloxicam tablets, instructions for use
Meloxicam is taken orally with meals. The daily dosage is 7.5 - 15 mg. For other forms of the drug, such as Meloxicam-Prana, Meloxicam-Lugal and Meloxicam-Ratiopharm, the dosage may differ.
For patients on hemodialysis with pathology of the renal system, the recommended dosage is 7.5 mg.
Meloxicam injections, instructions for use
The drug in the form of a solution of Meloxicam DS is prescribed to adolescents and adults over 15 years of age, 7.5 mg or 15 mg once a day deep intramuscularly during the first few days of treatment. For further therapy, it is more advisable to use oral forms of the drug.
Instructions for candles
Suppositories are administered rectally once a day (1 suppository - 15 mg).
The best substitutes in ampoules
For a faster and longer-lasting effect, the best way to administer NSAIDs is intramuscular use. Almost completely absorbed into the blood, the medicine immediately begins its anti-inflammatory effect. This route of administration leads to a reduction in pain within 30 minutes after the injection.
Injections with Meloxicam, as with its analogues, are characterized by a stronger and faster effect. However, NSAIDs in intramuscular ampoules should be used as little as possible. Having reduced the acute inflammatory response, after 3-4 days it is necessary to either discontinue high doses or reduce the dosage.
Amelotex
The drug is a Russian generic of Meloxicam. Produced and used in the same dosage and form. Prescribed in case of allergic reactions to additional components of other NSAIDs.
It has lower bioavailability and is absorbed into the blood by 89%, while meloxicam is absorbed by almost 100%. It affects fertility, which is why the drug is not recommended when planning pregnancy. Penetrates through the blood-placental barrier and into breast milk, which is why it is contraindicated for pregnant and lactating women. With frequent use, it can lead to the development of atrophic gastritis; it is prescribed with caution for gastrointestinal diseases.
Arthrozan
It has lower effectiveness due to the lower dose of the active substance in the ampoule (6 mg). It is recommended to use only at the beginning of treatment of the disease for several days. Then you should switch to other medications.
Effects of the drug
Arthrozan is characterized by high biodegradability. Like other NSAIDs based on meloxicam, it is contraindicated in nursing women and pregnant women. May lead to the development of anemia and thrombocytopenia. It should not be used together with other NSAIDs, especially acetylsalicylic acid. Refers to budget funds, in contrast to similar imported drugs.
Loxidol
The main active ingredient of Loxidol is also meloxicam. Produced by Romania jointly with Georgia. The product quickly and effectively relieves acute and chronic pain of the musculoskeletal system, including those of rheumatic origin. One ampoule contains the maximum permissible daily amount of the substance – 15 mg.
Long-term use of the product is not recommended. Often, 3 days of its use are enough to reduce pain, after which it is recommended to switch to smaller doses of the drug.
Contraindicated in pregnancy and lactating women, due to the risk of complications in the fetus and children.
Like other NSAIDs that inhibit COX-2, they have a lesser negative effect on the gastrointestinal mucosa, but with frequent use they can cause gastric ulcers. Available only by prescription.
Melbek
Turkish analogue of Meloxicam. It does not affect blood coagulation function if used in an acceptable dosage and not used in conjunction with other anti-inflammatory drugs. One ampoule contains 15 mg of the active ingredient (maximum daily dose).
Intramuscular use of the drug in this dosage is permissible only for several days. After which, you should reduce the dose and change the route of administration to oral or rectal, or stop using the drug.
Like other products with the same active ingredient, it is prohibited for diseases of the gastrointestinal tract, pregnancy and breastfeeding, individual intolerance to the medication and its individual components. Considering that its use significantly reduces the contraceptive ability of the intrauterine device, an unwanted pregnancy may occur.
Milixol
The Greek analogue of Meloxicam, which is prescribed for the relief of joint, muscle and bone pain, including those arising from rheumatological and autoimmune diseases. The ampoule contains 15 mg of active ingredient. It is permissible to use 1 ampoule per day.
For maximum effect and prevention of complications at the injection site, Milixol should be injected deep into the muscle.
Has good bioavailability and prolonged action. Long-term use of the drug increases the risk of developing peptic ulcers. Due to the ability to reduce platelet aggregation, it can lead to various bleedings, including uterine ones.
Milixol penetrates the hematoplacental barrier and can lead to the development of malformations in the fetus, therefore pregnancy and breastfeeding are contraindications for its use. The drug is not prescribed to children under 18 years of age.
Interaction
Myelotoxic medications cause an increase in the severity of hematotoxicity of Meloxicam.
With simultaneous therapy with other drugs of the NSAID , the risk of developing gastrointestinal bleeding and erosive and ulcerative lesions increases significantly.
Cholestyramine promotes the rapid elimination metabolites .
Heparin , ticlopidine , indirect anticoagulants, antihypertensive drugs increase the risk of bleeding .
Nephrotoxic effects are enhanced by cyclosporine .
Interaction with other drugs
Other prostaglandin synthesis inhibitors, including glucocorticoids and salicylates, when taken concomitantly with meloxicam, increase the risk of gastrointestinal ulceration and gastrointestinal bleeding (due to synergistic action) and are therefore not recommended.
Concomitant use with other NSAIDs is not recommended.
Selective serotonin reuptake inhibitors – increased risk of gastrointestinal bleeding.
Lithium preparations - NSAIDs increase the concentration of lithium in plasma by reducing its excretion by the kidneys. It is recommended to monitor lithium concentrations during the period of meloxicam administration, when changing the dose of lithium preparations and when discontinuing them.
Methotrexate - NSAIDs reduce the tubular secretion of methotrexate, thereby increasing its plasma concentration and hematological toxicity, while the pharmacokinetics of methotrexate does not change.
In this regard, simultaneous use of meloxicam and methotrexate at a dose of more than 15 mg/week is not recommended. With simultaneous use of drugs, the risk of increased toxicity of methotrexate increases.
The risk of interaction between NSAIDs and methotrexate may also occur in patients using low doses of methotrexate, especially in patients with impaired renal function. Therefore, constant monitoring of the number of blood cells and kidney function is necessary.
Contraception - when used simultaneously with intrauterine contraceptives, the effectiveness of the latter may be reduced.
Mifepristone - due to the theoretical risk of changes in the effectiveness of mifepristone under the influence of prostaglandin synthesis inhibitors, NSAIDs should not be prescribed earlier than 8-12 days after discontinuation of mifepristone.
Diuretics - the use of NSAIDs in case of dehydration of patients is accompanied by the risk of developing acute renal failure.
Antihypertensive drugs (beta-blockers and angiotensin-converting enzyme inhibitors, vasodilators, diuretics) - NSAIDs reduce the effect of antihypertensive drugs due to inhibition of prostaglandins that have vasodilating properties.
Angiotensin II receptor antagonists, when used together with NSAIDs, increase the reduction in glomerular filtration, which can thereby lead to the development of acute renal failure, especially in patients with impaired renal function.
NSAIDs, by acting on renal prostaglandins, may enhance the nephrotoxicity of cyclosporine.
When using medicinal products with a known ability to inhibit CYP2C9 and/or CYP3A4 (or are metabolized by these enzymes) with meloxicam, the possibility of pharmacokinetic interaction should be taken into account.
When taken simultaneously, meloxicam may enhance the effect of tablet antidiabetic drugs, thereby creating a risk of hypoglycemia.
Meloxicam may weaken the effect of digoxin, cortisone, and diuretics.
special instructions
Meloxicam is discontinued if side effects develop on the mucous membranes, skin, gastrointestinal bleeding , or peptic ulcers .
In patients with reduced glomerular filtration (after surgical treatment, with nephrotic syndrome , cirrhosis of the liver , chronic heart failure, dehydration , during treatment with diuretics), with a reduced BCC, the development of a clinical picture of chronic renal failure , which is reversible and disappears after completion therapy. Such patients need to undergo daily monitoring of renal function and diuresis.
In case of persistent and pronounced changes in the performance of the hepatic system, the drug is discontinued and special diagnostic tests are performed.
For patients at risk, Meloxicam is prescribed at a minimum dose of 7.5 mg.
The medication may affect driving and performance of certain types of work.
Popular tablet analogues
Most NSAIDs are available in tablet form with various dosages, but have lower bioavailability than when administered intramuscularly. The effectiveness of drugs is not related to the time of food intake, but due to the negative effect on the mucous membrane of the digestive tract, their use on an empty stomach is not recommended.
Tablet forms of Meloxicam, its analogues and substitutes act much less intensely, but their effect on the body is longer lasting.
Movalis
A German drug with meloxicam as an active ingredient. It is produced in the form of tablets and capsules of 7.5 and 15 mg. Used for short-term treatment of joint pain caused by exacerbation of osteoarthritis. Used for long-term treatment of chronic pain.
The maximum therapeutic effect is achieved 6 hours after administration and intensifies for at least 3 days. No more than 15 mg of the drug can be used per day. The use of high doses increases the risk of complications, including gastrointestinal ones.
Indications for use of Movalis
The medicine contains lactose, which is why Movalis is used with caution in case of lactose intolerance. Not used to relieve acute severe pain. The drug is contraindicated in patients with gastritis or peptic ulcer.
Due to the ability to reduce blood clotting, especially when using high doses of the drug, it is prescribed with caution to patients with hematological pathology. Movalis is contraindicated during pregnancy and pregnancy. You can purchase the medicine only with a doctor's prescription.
Bi-xicam
Russian medicine that relieves joint pain. Available in the form of small yellow tablets in two different dosages: 7.5 and 15 mg. Prescribed for various degenerative diseases of the musculoskeletal system or rheumatoid arthritis and other diseases leading to inflammation of the joints and muscles.
The drug has a fairly high level of bioavailability and long-lasting action. The maximum effect depends on the patient’s condition and the dosage of the drug, and occurs 3-5 hours after administration. The effect of the medicine does not depend on the time of food intake, but to reduce the risk of side effects, it is recommended to take Bi-xicam during or after meals.
It is possible to use the drug for chronic non-exacerbated gastritis or peptic ulcer in remission, but with caution. Contraindicated in people with aspirin-induced bronchial asthma.
Like other meloxicam-containing drugs, during pregnancy it penetrates through the bloodstream to the fetus. Can lead to various pathologies and stillbirth. Also passes into breast milk. Because of this, the use of the drug throughout pregnancy and pregnancy is strictly contraindicated.
Mirlox
The drug, produced by a Polish pharmacological company based on meloxicam, blocks COX-2. In this way, the mucous membrane of the gastrointestinal tract is less affected. Available in the form of tablets of 15 and 7.5 mg. The effect of the drug lasts up to 5 days.
It is recommended to use the minimum dose of the medication as long as its effectiveness is maintained. If the pain does not stop and does not decrease, the dose should be increased, but not exceeding 15 mg per day.
Like other NSAIDs, it may increase the risk of bleeding, especially when taking anticoagulants and antiplatelet agents simultaneously. Contraindicated in nursing and pregnant women, patients after coronary artery bypass surgery, children under 18 years of age, in the presence of allergic reactions to meloxicam and individual components of the drug.
Use with caution in the elderly and people with heart, kidney and liver failure. To achieve a prolonged effect, it is necessary to undergo a course of treatment for at least 5-7 days. If there is an increased risk of side effects and concurrent use of other medications, it is recommended to use Mirlox no more than 7.5 mg per day after meals.
Amelotex
The drug, manufactured in the Republic of Macedonia, is a generic version of meloxicam. The medicine is available in dosages of 7.5 mg and 15 mg. The drug is well absorbed in the stomach regardless of food intake and begins its effect after 3-5 hours. After 6 hours the maximum result is achieved. Amelotex can be used by children over 15 years of age up to 7.5 mg per day. Not addictive.
With long-term use of the drug, there is no addiction or reduction in effectiveness. Prescribed with caution to patients with a history of gastrointestinal bleeding. Its use is also not recommended for people with kidney failure, since most of the drug is excreted through the kidneys in the urine.
Movalgin
An anti-inflammatory and anti-rheumatic drug, which is manufactured in Canada, based on meloxicam. It is quite effective and is almost completely absorbed into the blood when taken orally. Available in the form of tablets of 15 and 7.5 mg.
To reduce the risk of complications and undesirable effects, it is recommended to use Movalgin up to 7.5 mg per day. If necessary, it is possible to use the drug for more than 10 days, but this leads to the risk of developing atrophic gastritis and bleeding.
The drug has not undergone clinical trials for the treatment of chronic and acute inflammatory reactions in children, and is therefore contraindicated in patients under 16 years of age. Due to the ability to penetrate into the bloodstream of the fetus and into breast milk, it is not used during pregnancy and breastfeeding.
Use with caution in elderly people and patients with kidney disease. Parallel use of lithium-containing drugs leads to impaired excretion of lithium and the development of intoxication of the body.
Meloxicam analogs
Level 4 ATX code matches:
Mirlox
Revmoxicam
Xefocam Rapid
Xefocam
Movalis
Mesipol
Lem
Melbek
Movasin
Piroxicam
Lornoxicam
Arthrozan
Texamen
Amelotex
Aroxicam , Aspicam , Zeloxim , Melbek , Melox , Meloxam , M-Kam , Movalgin , Movalis , Revmalgin , Rekoxa , Existen-Sanovel .
Basically, the price of Meloxicam analogues is higher than that of the original drug.
Reviews about Meloxicam
There are many reviews of Meloxicam tablets and reviews of Meloxicam DS injections. Here are some of them:
- “...Meloxicam tablets relieve pain very well and help with cervical osteochondrosis and neck pain. Almost after one tablet, the pain subsides and completely goes away after the full course of treatment with the drug;
- “... I took the medicine one tablet twice a day. Already on the 4th day everything stopped hurting, but I finished the full ten-day course to the end. The dosage of the tablets was 7.5 mg."
Reviews from doctors about the drug Meloxicam in all forms of release and Meloxicam Teva are generally more positive.
The cheapest similar products
In most cases, diseases of the musculoskeletal system are accompanied by prolonged and frequent pain. Many drugs are quite expensive, and not all patients have the opportunity to buy expensive drugs. But there are effective substitutes, the cost of which is cheaper than most similar drugs.
Melox
Medication in the middle price category, imported from Cyprus. One tablet contains 15 mg of meloxicam. Absorbed into the gastrointestinal tract almost 100%. With a single use, the maximum effect occurs 6 hours after administration, long-term use leads to a faster achievement of the effect after use.
However, frequent use of NSAIDs increases the risk of complications, including gastrointestinal bleeding. The use of corticosteroids enhances the anti-inflammatory effect of meloxicam. Not for children and pregnant women.
When using it, you should stop breastfeeding. Can be used for mild to moderate pulmonary and renal failure, but not more than 7.5 mg per day. Contraindicated for use in patients taking Methotrexate.
Movasin
A Russian drug containing 7.5 or 15 mg of meloxicam in one tablet. It is quickly and almost completely absorbed through the gastrointestinal tract into the blood and begins to act within 3-5 hours. Regular use of the medication for more than 1 year does not affect its effectiveness, but can lead to the development of dangerous side conditions:
- gastrointestinal ulcers;
- bleeding of internal organs;
- bleeding disorders due to the effect on platelet aggregation.
Description of the drug
Not prescribed for children under 18 years of age, during pregnancy and breastfeeding. It is almost completely metabolized in the liver, therefore it is contraindicated in the presence of liver diseases and insufficiency. The medication is prohibited for patients with chronic and acute gastritis. It is undesirable for elderly patients, especially in the presence of concomitant pathologies from the gastrointestinal tract and hematological system.
Diclofenac
A drug based on diclofenac sodium. NSAIDs that inhibit COX-2, resulting in a more pronounced effect on the gastric mucosa. Available in the form of tablets, suppositories and solution for intramuscular injection. It has a strong anti-inflammatory effect with antipyretic properties, but does not relieve severe and acute pain.
Pharmacological features of Diclofenac
Diclofenac is generally prescribed in the complex symptomatic treatment of osteoarthritis, arthritis and osteoporosis to relieve the inflammatory process in tissues and reduce pain symptoms. It acts more effectively and quickly when administered intramuscularly. After oral and rectal administration, the maximum effect is observed after 6-8 hours.
The drug often leads to the development of gastric ulcers, helps to reduce blood clotting and the occurrence of various bleedings. Prohibited in the presence of renal and liver failure. Long-term treatment with this medication is not recommended.
Meloxicam price, where to buy
Price Meloxicam tablets 7.5 mg 20 pcs. – 60 rub. The average price of Meloxicam in injections is 90 rubles. for a pack of 3 ampoules. The cost of Meloxicam-Prana tablets is 40-50 rubles. The average price for candles is 200 rubles.
The price of Meloxicam ampoules in Ukraine is 90-170 UAH, the cost of the drug in tablets is 45-150 UAH.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Meloxicam-Lekpharm solution for intramuscular administration 0.01 g/ml 1.5 ml 3 pcs SOOO Lekpharm
207 rub. order - Meloxicam solution for intramuscular injection. 0.01g/ml 1.5ml 3pcsOzon LLC
185 rub. order
- Meloxicam-Teva tablets 15 mg 10 pcs. Pharmaceutical plant Teva Private Co. Ltd.
RUB 195 order
- Meloxicam Avexima tablets 7.5 mg 20 pcs. JSC Irbitsky Chemical Plant
99 RUR order
- Meloxicam-Teva tablets 7.5 mg 20 pcs. Teva Pharmaceutical Works Private Limited Company
RUB 202 order
Pharmacy Dialogue
- Meloxicam (tab. 15 mg No. 20)Vertex
RUB 256 order
- Meloxicam (tab. 7.5 mg No. 20) Kanofarma CJSC
55 rub. order
- Meloxicam (amp. 10 mg/ml 1.5 ml No. 3) Ozone LLC
164 RUR order
- Meloxicam-Akrikhin (tab. 7.5 mg No. 20) Uniquem Laboratories
87 RUR order
- Meloxicam-Teva (tab. 15 mg No. 20) Teva
270 rub. order
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Pharmacy24
- Meloxicam-LH 0.015 g No. 20 tablets AT "Lekhim-Kharkiv", Ukraine
56 UAH order - Meloxicam-KV 15 mg N20 tablets PAT "Kiev Vitamin Plant", Kiev, Ukraine
74 UAH order
- Meloxicam-Teva 15 mg/1.5 ml No. 5 solution
125 UAH order
- Meloxicam N 10 mg/ml 1.5 ml No. 5 solution for injection
132 UAH order
- Meloxicam-Teva 15 mg No. 10 tablets Merkle GmbH, Nimechchina
62 UAH.order
PaniPharmacy
- MELOXICAM ampoule Meloxicam solution d/in. 10 mg/ml 1.5 ml No. 5 Ukraine, Pharmstandard-Biolek
91 UAH order
- MELOXICAM tablets Meloxicam-Lx tablets. 0.015g No. 20 Ukraine, Lekhim-Kharkov CJSC
64 UAH order
- MELOXICAM ampoule Meloxicam solution d/in.15 mg/1.5 ml.amp. No. 5, Zentiva
171 UAH order
- MELOXICAM ampoule Meloxicam-ratiopharm solution d/in.15mg/1.5ml No. 5 Greece, Help
128 UAH order
- Meloxicam tablet 7.5 mg No. 20 Ukraine, MaxPharma
102 UAH order
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