Manufacturer: Walmark Co.
(Czech Republic) Active ingredients
- Not indicated. See instructions
Pharmacological action
- Not indicated. See instructions
- Description of the pharmacological action of Arthrostop Plus
- Composition Arthrostop Plus
- Release form of the drug Arthrostop Plus
- Contraindications to the use of the drug Arthrostop Plus
- Method of administration and dosage of the drug Arthrostop Plus
- Precautions when taking Arthrostop Plus
- Storage conditions for the drug Arthrostop Plus
- Shelf life of the drug Arthrostop Plus
Description of pharmacological action
Provides the body with substances needed to protect and regenerate joints. Thanks to a unique combination of glucosamine, MSM, Boswellia Serrata bark extract and manganese, ArthroStop Plus has a positive effect on increasing the strength and mechanical properties of joints, as well as reducing the feeling of stiffness in the joints. Glucosamine is a structural component of articular cartilage, responsible for strength and flexibility. It is normally found in the human body and is an important component for the synthesis of collagen and other compounds that are responsible for the elasticity and flexibility of cartilage.
Dekristol 20000 D3 capsules 50pcs/pack - Instructions
Compound
The main functional substance of the drug is an oil solution of cholecalciferol (which corresponds to 500 mcg of cholecalciferol or 20,000 IU of vitamin D3).
Other Ingredients: Refined peanut oil, gelatin, glycerin 85%, triglycerides of medium chain saturated fatty acids, purified water, all-rac-α-tocopherol.
Release form
This product is produced in the form of soft transparent gelatin capsules, packaged in packages of 50 pieces.
pharmachologic effect
Vitamin D3 (cholecaciferol) is usually synthesized in the skin from 7-dehydrocholesterol under the influence of solar radiation. In conditions of insufficient lighting, cholecalciferol deficiency may occur.
Pharmacological activity is demonstrated by 3 main metabolites of cholecalciferol:
- calcifediol (25-hydroxycholecalciferol);
- calcitriol (1,25-dihydroxycholecalciferol);
- 24,25-dihydroxycholecalciferol.
Calcifediol and calcitriol increase calcium levels in the blood. The mechanism of action of active metabolites of cholecalciferol is the stimulation of steroid receptors responsible for the regulation of transcription and translation processes. Combination with receptors of cell nuclei leads to an increase in the synthesis of proteins associated with the absorption of calcium and phosphate ions from the gastrointestinal tract, and also increases the activity of cells associated with bone tissue resorption (osteoclasts). The process of bone resorption ensures adequate strength.
The complex of active metabolites of vitamin D3 is also responsible for increased absorption of calcium and phosphate in the kidneys and decreased release of parathyroid hormone.
Pharmacokinetics
Absorption of the active substance occurs in the small intestine. The absorption of vitamin D3 can be improved if the drug is taken in the presence of fat.
Cholecalciferol is rapidly transported to liver cells. Cholecalciferol and its active metabolites bind in plasma to the α2 protein transporter globulin (transcalciferin).
Transcalciferin binds most strongly to calcifediol (25-hydroxycholecalciferol).
Vitamin D3 is stored in muscles, liver cells and adipose tissue. The half-life of colecalciferol metabolites varies. 24,25-dihydroxycalciferol remains the longest in the body.
The active substance and its metabolites pass into breast milk and through the placenta.
The metabolism of cholecalciferol is multistage. The active substance is hydroxylated in the liver after the action of the enzyme 25-hydroxylase on calcifediol.
The next step in the biotransformation of the drug molecule is the treatment of calcifediol with 25-hydroxycalciferol-α-hydroxylase. As a result of the reaction, calcitriol is formed - 1,25-dihydroxycalciferol.
There is also an alternative pathway for the conversion of calcifediol in the kidneys. The calciferol derivative, as a result of the action of 24-hydroxylase, can be converted into a compound with lower activity - 24,25-dihydroxycalciferol.
The degree of α-hydroxylase activity in the kidneys depends on dietary intake of calcium, vitamin D3 and phosphate, as well as on the influence of parathyroid hormone, estrogens and prolactin.
A small amount of vitamin D3 and its metabolites was found in the urine. The active substance and its derivatives are excreted in bile and feces after conjugation with glucuronic acid.
Indications for use
Decrystol is used to prevent and treat vitamin D3 deficiency. The active substance has also found use in the adjunctive therapy of osteoporosis with concomitant vitamin D3 deficiency.
The drug is recommended for the prevention and treatment of rickets in children, as well as for the prevention of cholecalciferol deficiency in people at risk.
Contraindications
Hypersensitivity to the active substance is a contraindication to the use of Decrystol. Other restrictions on the use of the drug in therapy are:
- excessive concentration of vitamin D3 in plasma;
- too much calcium in the blood (hypercalcemia) or urine (hypercalciuria);
- stones in the kidneys;
- sarcoidosis;
- severe renal failure;
- nephrocalcinosis (nephrocalcinosis);
- suspected hypoparathyroidism.
Side effects
Symptoms of an allergic reaction may occur while taking this medication and include: swollen face, swollen tongue/lips, throat, difficulty breathing/swallowing, hives.
The peanut oil in this medicine may cause allergic reactions.
Drug interactions
Decrystol should not be used with other vitamin D analogues (for example, calcitriol), thiazide diuretics.
Dextrystol may be less effective when used simultaneously with glucocorticosteroids, orlistat, imidazole derivatives, paraffin laxatives, phenytoin, and barbiturates.
Decrystol can enhance the effect of cardiac glycosides - the risk of arrhythmias caused by increased calcium levels increases.
Ion exchange resins and laxatives may reduce the absorption of the active substance from the gastrointestinal tract.
Application and dosage
The dosage regimen of Decrystol depends on the patient’s age and weight, the degree of vitamin D deficiency and underlying diseases. It is recommended to take the drug with the main meal.
In the case of prophylactic use in infants and newborns, it is recommended to administer 500 IU of the drug daily. Vitamin D3 supplementation for premature infants involves taking 1,000 IU daily until 10 months.
The recommended prophylactic dose of the drug is from 800 IU to 2000 IU per day. In patients suffering from severe cholecaciferol deficiency, the dose of Decristol ranges from 800 IU to 4000 IU
In some cases, it is recommended to administer an additional supply of calcium while taking Decrystol, and obesity and other diseases should be taken into account when determining the dose.
Overdose
Taking too much of the active substance may cause an increase in plasma calcium or phosphorus levels (hypercalcemia and hyperphosphatemia).
Prolonged high plasma calcium levels can lead to tissue calcification and kidney damage. Symptoms of overdose include polyuria (polyuria), kidney stones, bone pain, arrhythmia, confusion, vomiting, decreased muscle strength, decreased appetite or anorexia, and increased thirst.
Therapy is carried out in accordance with the emerging symptoms.
special instructions
The use of high doses of the drug is not recommended for pseudohypoparathyroidism.
When adjusting the dose of vitamin D, it is recommended to take into account various sources of cholecalciferol (diet, production of vitamin D3 in the skin). The use of therapeutic doses of the drug should be based on a systematic analysis of plasma calcium.
Patients suffering from sarcoidosis should be especially careful when taking Decrystol. Increased conversion of cholecacalciferol to its active metabolite may increase the risk of drug-related side effects.
Caution should be exercised when treating patients with renal failure. The drug may cause soft tissue calcification, leading to worsening kidney failure. In some cases, it is necessary to regularly check the level of calcium and phosphate in the urine; the development of hypercalciuria (increased calcium levels in the urine) should lead to discontinuation of the drug.
In addition, elderly patients taking diuretics and cardiac glycosides should have their plasma creatinine tested regularly during treatment with Decrystol.
Use during pregnancy and breastfeeding
During pregnancy, it is recommended to take 1500 IU to 2000 IU of the drug daily. For patients with a BMI over 30 kg/m2, the amount of active substance should be adjusted accordingly.
In some situations, it is recommended to take lower doses of the drug depending on the degree of cholecalciferol deficiency. High doses of vitamin D3 should be avoided during pregnancy due to the risk of soft tissue calcification. Elevated calcium levels can impair a child's physical and mental development.
Studies have confirmed the ability of the active substance to penetrate into the milk of a nursing woman. During breastfeeding, dosages of 400 to 2000 IU are usually recommended. The demand for Decrystol during breastfeeding depends on the deficiency of the active substance.
Before starting to take the drug during breastfeeding, it is necessary to take into account the additional intake of vitamin D3 (diet, production through the skin).
If the active substance is used in infants or newborns, careful monitoring of the child is recommended. Infants may respond better to higher doses of the active ingredient.
It is not recommended to take multiple medications containing vitamin D3 due to the risk of overdose.
Impact on the ability to drive vehicles and operate machinery
No special precautions are required.
Terms of sale
Over the counter.
Storage conditions
At room temperature in a dry place, away from children.
Best before date
36 months
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The description of vitamin Arthrostop Plus is intended for informational purposes only. Before starting to use any drug, it is recommended to consult a doctor and read the instructions for use. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the project does not replace consultation with a specialist and cannot be a guarantee of the positive effect of the drug you use. The opinions of EUROLAB portal users may not coincide with the opinions of the site Administration.
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Arthrostop Rapid plus tablets 180 pcs. — Instructions
Release form
Tablets, pack 180 pcs.
Compound
- glucosamine sulfate – 1600 mg
- chondroitin sulfate – 600 mg
- Boswellia extract – 150 mg
- collagen type 2 20 mcg
- ascorbic acid 12 mg
pharmachologic effect
ArtoStop Plus Rapid provides high-quality nutrition for joints and the entire musculoskeletal system. Glucosamine is a natural component that is part of body tissues. It is the main building material for the biosynthesis of collagen and other substances necessary for the good condition and elasticity of cartilage. As a natural component, glucosamine supports healthy joints, bones and tendons. Glucosamine hydrochloride is the pure form of glucosamine. MSM (methylsulfonylmethane) is an important component of collagen with a positive effect on the condition of the skin, hair, nails and soft tissues. MSM promotes the proper formation and functioning of cartilage and bone tissue. Boswellia tree bark extract has a positive effect on the musculoskeletal system and plays a significant role in strengthening bones, joints and muscles. Type 2 collagen and ascorbic acid - ExPur complex - supports joint health
Action of the drug:
-helps ensure the delivery of nutrients necessary for the physiological structure and maintenance of joint mobility -effectively protects and nourishes joints -improves the mechanical and resistance properties of joints -effective when signs of premature wear of joints and spine appear -effective for increased physical activity, obesity and after musculoskeletal injuries musculoskeletal system - promotes cartilage restoration
Indications for use
Arthrostop Rapid Plus is used in complex treatment of: deforming osteoarthritis, infectious arthritis, rheumatism, rheumatoid arthritis, injuries and dislocations of joints, congenital joint defects.
Directions for use and dosage
Adults: 1 tablet
3 times a day. Children (over 14 years old): 1 tablet per day, after meals, with water.
Recommended period of use: 2-3 months.
Side effects
There are no side effects reported when consuming the recommended daily dose.
Precautionary measures
None.
Contraindications
Individual intolerance to product components.
special instructions
Do not exceed the recommended daily intake. The dietary supplement cannot be used as a meal replacement for various diets.
Storage conditions
Store in a dry, dark place at temperatures below 25°C, away from sunlight. Keep out of the reach of children, in the original packaging.
Best before date
3 years. The expiration date is indicated on the packaging.