pharmachologic effect
Cyanocobalamin is a biologically active drug that has hematopoietic, erythropotic, metabolic and antianemic effects. Accelerates tissue healing processes, normalizes the functioning of the central nervous system and the hematopoietic system, improves processes in the liver, enhances the activity of thromboplasts and prothrombin , activates the blood clotting process, reduces the amount of cholesterol in the blood.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Activates the metabolism of proteins, fats and carbohydrates . Forms an energy reserve in the body and actively participates in the process of transmitting nerve impulses. It is part of phosphocreatine and promotes the accumulation of hemoglobin in red blood cells . Stimulates bone marrow (normoblastic erythropoiesis). This drug normalizes liver function , has a positive effect on the blood coagulation system, and in high doses increases prothrombin .
Pharmacokinetics
The drug is absorbed primarily in the small (less in the large) intestine, then transported into the cell through the receptor system. In the blood it combines with transcobalamins I and II, and then is transported to tissues, where it is metabolized. In the body, this vitamin is deposited in the liver. It is excreted from the body by the renal excretory system.
Contraindications
The use of cyanocobalamin tablets has several strict contraindications:
- allergic response to any substance in the solid form;
- excess of normal levels of hemoglobin and red blood cells;
- tendency to thrombosis;
- primary polycythemia (Vaquez disease).
Mono-preparations of cyanocobalamin are used with caution in oncology, heart failure, and angina pectoris. Pregnancy and age under 14 years are relative contraindications to taking vitamin B-12, which is due to the need for strict dosage selection based on test results.
Indications for use of the drug
- iron deficiency anemia of various origins;
- folate deficiency and vitamin deficiency anemia ;
- cirrhosis of the liver;
- dystrophy in young children;
- motor neuron disease;
- lumbosacral radiculitis ;
- cerebral palsy in children;
- lesions of the trigeminal nerve;
- multiple sclerosis ;
- polyneuropathy;
- chronic hepatitis ;
- Down syndrome;
- neuralgia, neuritis;
- skin diseases ( psoriasis , eczema ).
Instructions for use of Cyanocobalamin (Method and dosage)
The drug is administered intramuscularly, intravenously, subcutaneously and intralumbarally . Therapy with Cyanocobalamin is accompanied by regular monitoring of coagulation parameters and the overall blood picture. The dosage of the drug depends on the specific disease:
- for aplastic anemia, 100 mcg is administered every other day until hematological and clinical improvement is obtained;
- for iron deficiency and posthemorrhagic anemia - 30-100 mcg three times a week;
- anemia in children - 40 mcg per day for 15 days;
- neurological traumatic diseases and diseases of the nervous system - in increasing doses from 250 to 500 mcg, duration of treatment - up to 2 weeks; if the patient's condition improves - 100 mcg per day;
- damage to peripheral nerves caused by trauma - 200–400 mcg every other day for one and a half months;
- Down's disease , cerebral palsy and dystrophies in children - 15–30 mcg per day;
- diabetic neuropathy , radiation sickness - 60-100 mcg for a whole month.
- hepatitis and cirrhosis of the liver - 100 mcg per day for 30 days;
- funicular myelosis , multiple sclerosis - 15–30 mcg of solution is administered, gradually increasing the dose from 200 to 500 mcg.
Interaction
Cyanocobalamin is a vitamin that is incompatible with thiamine bromide, riboflavin and pyridoxine (in one syringe). When prescribed simultaneously with antibiotics ( kanamycin, polymyxins, neomycin and tetracyclines ), the absorption of this medicine becomes difficult. Do not take together with drugs that affect blood clotting. Therefore, if you have been prescribed Cyanocobalamin, the instructions for use should be carefully studied.
Compound
B-12 preparations may contain cyanocobalamin, adenosylcobalamin or methylcobalamin. The first of them is a synthetic substance that, when it enters the body, is metabolized to bioavailable forms.
Adenosyl- and methyl-cobalamins are of natural origin, do not undergo processing by the liver, and therefore are used for pathologies of this organ (cirrhosis, hepatitis, fatty degeneration).
None of these types of drugs can be called preferable. For some, the natural composition is more suitable, for others it is not absorbed and a synthetic analogue is required. Therefore, the active substance is selected on the recommendation of a doctor or according to the availability of the drug.
Efficacy is then monitored in the laboratory after 2 weeks. If there are no results, the drug should be changed. Most often, positive dynamics are observed precisely when using artificially synthesized cyanocobalamin.
Additionally, tablets may contain various ingredients to stabilize the composition, give it shape and ensure solubility. The most commonly used are silicon dioxide, povidone, stearic acid, microcellulose, talc, and titanium dioxide. They are excipients that do not affect the therapeutic effect.
https://www.youtube.com/watch?v=R4aVSkitrMM
Analogs
Cyanocobalamin-Darnitsa, Cyanocobalamin - Vial, Cyanocobalamin Bufus, Medivitan.
Combination preparations containing vitamin B12
There are a number of combination drugs on the market - Cyanocobalamin tablets in combination with folic acid (Russia), Nowfoods B12, Solgar Vitamin B12 (USA), Neurobion (Germany), Neurovitan (Italy). As a rule, the release form is tablets.
In what form is it produced?
The injection form of the drug today is chosen only when an urgent result is needed, in severe conditions or ineffectiveness of enteral supplementation.
Any diseases of the gastrointestinal tract that occur with a decrease in acidity or a violation of the Castle factor lead to 100% excretion of cyanocobalamin through the intestines. This makes taking the pills ineffective.
Cyanocobalamin tablets
In all other cases, the drug is taken orally, as the most convenient form of therapy. Cyanocobalamin tablets are a compressed active substance along with additional ingredients. Solid oral forms are usually cheaper than other forms of the drug, and they are easy to divide into parts if divided doses are needed.
It is difficult to determine the average price for tablet forms of vitamin B-12. Dietary supplements are produced by many companies, and the price per tablet can range from 2 to 20 rubles.
There are also chewable lozenges and capsules that can be convenient if you have difficulty swallowing or assimilating. But it should be noted that these forms of cyanocobalamin include additional substances that are not related to the therapeutic effect: dyes, gelling agents, sweeteners, flavorings.
By researching the composition of a particular drug, you can choose capsules or tablets that are suitable for vegetarians, vegans, or that include additional ingredients that increase the absorption of B-12 (for example, vitamin B-6, folic acid, and others).
Cyanocobalamin tablets have different dosages. The most popular are tablets containing 0.5 and 1 mg of active nutrients. Drugs with a dosage of 5 and 10 mg are used exclusively as prescribed by a doctor and according to strict indications.
Reviews of Cyanocobalamin
Reviews about the drug are mostly positive. Patients note that after a course of treatment, hemoglobin increases, well-being is normalized and sleep improves, depression goes away, pain from neuralgia and inflammation of the trigeminal nerve decreases.
According to patient reviews, Cyanocobalamin in ampoules is an effective hair product. Many women are interested in how to use Cyanocobalamin for hair? Like all B vitamins, it has a positive effect on hair. Even regular (once a week) injections of the drug help strengthen hair roots and reduce hair loss. The drug is often used as a component of hair masks or in its pure form for rubbing into the hair roots.
Side effects
A course or single dose of cyanocobalamin can cause adverse reactions of varying severity. The most common symptoms are mild weakness, dizziness, and problems falling asleep.
Other side effects possible when taking cyanocobalamin:
- increased anxiety, irritability;
- migraine-type headache;
- increased body temperature;
- disorders of the gastrointestinal tract.
Pain in the joints, muscles, and aches of the whole body are much less common. If any unusual reactions occur, a medical examination is required to decide whether to discontinue or continue taking the drug, as well as adjust the dose.
Cyanocobalamin price, where to buy
You can buy the drug in all pharmacies. The price of Cyanocobalamin in Moscow pharmacies varies from 14.5 to 25.0 rubles per pack.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Blagomin Vitamin B12 (cyanocobalamin) capsules 9 mcg 0.2 g 90 pcs. VIS LLC
211 rub. order - Cyanocobalamin (Vitamin B12) solution for in. 0.5 mg/ml 1 ml 10 pcs. JSC Dalkhimfarm
48 RUR order
Pharmacy Dialogue
- Vitamin B12 (cyanocobalamin) (amp. 500 µg/1 ml No. 10) DHF JSC
49 RUR order
- Vitamin B12 (cyanocobalamin) (amp. 500 µg/1 ml No. 10) Yerevan chemical plant
36 RUR order
- Blagomin Vitamin B12 (cyanocobalamin) (caps. 200 mg No. 90) VIS LLC
RUB 244 order
- Vitamin B12 (cyanocobalamin) (amp. 500 µg/1 ml No. 10) BZMP
46 RUR order
- Cyanocobalamin (Vitamin B12) (amp. 500 µg/1 ml No. 10) BZMP OJSC
48 RUR order
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Pharmacy24
- Cyanocobalamin-Darnitsa 0.02% 1 ml No. 10 solution PrAT" Pharmaceutical company "Darnitsa", Ukraine
14 UAH. order - Cyanocobalamin 0.05% 1 ml No. 10 injection solution PAT "Galichfarm", Ukraine
12 UAH order
- Cyanocobalamin-Darnitsa 0.05% 1 ml No. 10 solution for injection PrAT" Pharmaceutical company "Darnitsa", Ukraine
17 UAH order
PaniPharmacy
- Cyanocobalamin solution for injection 0.05% ampoule 1 ml No. 10 Ukraine, Darnitsa ChAO
18 UAH order
- Cyanocobalamin solution for injection 0.02% ampoule 1 ml No. 10 Ukraine, Darnitsa ChAO
16 UAH order
- Cyanocobalamin solution for injection 0.05% ampoule 1 ml No. 10 Ukraine, Galichfarm JSC
14 UAH order
- Cyanocobalamin solution for injection 0.05% ampoule 1 ml No. 10 Ukraine, Lekhim-Kharkov JSC
16 UAH order
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